Claims for Patent: 8,889,722
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Summary for Patent: 8,889,722
| Title: | Pharmaceutical composition containing optically active compound having thrombopoietin receptor agonist activity, and intermediate therefor |
| Abstract: | An optically active 4-phenylthiazole derivative having a thrombopoietin receptor agonist activity and a pharmaceutical composition containing the present compound as an active ingredient are created, and a platelet production regulating agent which can be orally administered is provided. Disclosed is a pharmaceutical composition containing, as an active ingredient, an optically active compound represented by the formula: ##STR00001## wherein, R.sup.1 is a halogen atom or C1-C3 alkyloxy; R.sup.2 is C1-C8 alkyl; R.sup.3 is C1-C8 alkyl; R.sup.4 and R.sup.5 are each independently a fluorine atom or chlorine atom; R.sup.6 is C1-C3 alkyl or C1-C3 alkyloxy; * indicates that a carbon atom marked with an asterisk is an asymmetric carbon, a pharmaceutically acceptable salt thereof, or a solvate thereof. |
| Inventor(s): | Takayama; Masami (Osaka, JP), Kurose; Noriyuki (Osaka, JP) |
| Assignee: | Shionogi & Co., Ltd. (Osaka-Shi, Osaka, JP) |
| Application Number: | 13/766,752 |
| Patent Claims: |
1. A pharmaceutical composition comprising, as an active ingredient, a compound of formula: ##STR00024## a pharmaceutically acceptable salt thereof; or a solvate
thereof.
2. The pharmaceutical composition according to claim 1, comprising the active ingredient in an amount effective as a thrombopoietin receptor agonist. 3. The pharmaceutical composition according to claim 1, comprising the active ingredient in an amount effective as a platelet production regulating agent. 4. A crystal of (S)-(E)-3-(2,6-dichloro-4-{4-[3-(hexyloxyethyl)-2-methyloxyphenyl]thiazol- -2-ylcarbamoyl}phenyl)-2-methylacrylic acid. 5. A pharmaceutical composition comprising, as an active ingredient, the crystal as defined in claim 4. 6. The pharmaceutical composition according to claim 5, comprising the active ingredient in an amount effective as a thrombopoietin receptor agonist. 7. The pharmaceutical composition according to claim 5, comprising the active ingredient in an amount effective as a platelet production regulating agent. |
