Claims for Patent: 8,901,123

Summary for Patent: 8,901,123

Title:	Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,- 4]triazin-2-yl]benzamide and processes related to preparing the same
Abstract:	The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin- -2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-- 2-yl]benzamide, and salts thereof.
Inventor(s):	Weng; Lingkai (Malvern, PA), Qiao; Lei (Downingtown, PA), Zhou; Jiacheng (Newark, DE), Liu; Pingli (Newark, DE), Pan; Yongchun (Newarl, DE)
Assignee:	Incyte Corporation (Wilmington, DE)
Application Number:	13/793,864
Patent Claims:	1. A method of inhibiting activity of a receptor or non-receptor tyrosine kinase comprising contacting said kinase with 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-- 2-yl]benzamide dihydrochloric acid salt, or a hydrate or solvate thereof, wherein said kinase is c-Met. 2. A method of inhibiting the HGF/c-Met kinase signaling pathway in a cell comprising contacting said cell with 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-- 2-yl]benzamide dihydrochloric acid salt, or a hydrate or solvate thereof. 3. A method of inhibiting the proliferative activity of a cell comprising contacting said cell with 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-- 2-yl]benzamide dihydrochloric acid salt, or a hydrate or solvate thereof.