Claims for Patent: 8,906,938

Summary for Patent: 8,906,938

Title:	C5aR antagonists
Abstract:	Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
Inventor(s):	Fan; Pingchen (Fremont, CA), Greenman; Kevin Lloyd (Sunnyvale, CA), Leleti; Manmohan Reddy (Sunnyvale, CA), Li; Yandong (San Jose, CA), Powers; Jay P. (Pacifica, CA), Tanaka; Hiroko (Foster City, CA), Yang; Ju (Cupertino, CA), Zeng; Yibin (Foster City, CA)
Assignee:	ChemoCentryx, Inc. (Mountain View, CA)
Application Number:	13/894,209
Patent Claims:	1. A compound having the formula ##STR00037## or a pharmaceutically acceptable salt or rotamer thereof. 2. The compound of claim 1, in a pharmaceutically acceptable salt form. 3. A composition comprising a pharmaceutically acceptable carrier and a compound having the formula: ##STR00038## or a pharmaceutically acceptable salt, hydrate or rotamer thereof. 4. A compound having the formula: ##STR00039## 5. A pharmaceutical composition comprising a compound having the formula ##STR00040## and a pharmaceutically acceptable carrier.