Claims for Patent: 8,927,540

Summary for Patent: 8,927,540

Title:	Pyridazinone derivatives
Abstract:	Compounds of the formula (I), in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.4', have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumors.
Inventor(s):	Dorsch; Dieter (Ober-Ramstadt, DE), Stieber; Frank (Heidelberg, DE), Schadt; Oliver (Rodenbach, DE), Blaukat; Andree (Muehltal, DE)
Assignee:	Merck Patent GmbH (Darmstadt, DE)
Application Number:	13/785,580
Patent Claims:	1. A method for treating a disease in which the inhibition, regulation and/or modulation of kinase signal transduction plays a role or a method for inhibiting Met kinase and/or tyrosine kinase, comprising administering to a patient in need thereof an effective amount of a compound of formula I ##STR00210## in which R.sup.1 denotes Ar or Het, R.sup.2 denotes an unsaturated, saturated or aromatic 6-membered heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R.sup.3).sub.2].sub.nOR.sup.3, N.dbd.CR.sup.3N(R.sup.3).sub.2, SR.sup.3, NO.sub.2, CN, COOR.sup.3, CON(R.sup.3).sub.2, NR.sup.3COA, NR.sup.3SO.sub.2A, SO.sub.2N(R.sup.3).sub.2, S(O).sub.mA, [C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, [C(R.sup.3).sub.2].sub.nHet, O[C(R.sup.3).sub.2].sub.pOR.sup.3, O[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nC.ident.C[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.- 2, O[C(R.sup.3).sub.2].sub.nN.sup.+O.sup.-(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nHet, S[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, S[C(R.sup.3).sub.2].sub.nHet, NR.sup.3[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, NR.sup.3[C(R.sup.3).sub.2].sub.nHet, NHCON(R.sup.3).sub.2, NHCONH[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, NHCONH[C(R.sup.3).sub.2].sub.nHet, [C(R.sup.3).sub.2].sub.nNHCO[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, [C(R.sup.3).sub.2]NHCO[C(R.sup.3).sub.2].sub.nHet, CON(R.sup.3).sub.2, CONR.sup.3[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, CONR.sup.3[C(R.sup.3).sub.2].sub.nNR.sup.3COOA, CONR.sup.3[C(R.sup.3).sub.2].sub.nOR.sup.3, CONR.sup.3[C(R.sup.3).sub.2].sub.nHet, COHet, COA, CH.dbd.CH--COOR.sup.3, CH.dbd.CH--N(R.sup.3).sub.2 and/or .dbd.O, R.sup.3 denotes H or A, R.sup.4, R.sup.4' each, independently of one another, denote H, Hal, A, OR.sup.3, CN, COOR.sup.3, CON(R.sup.3).sub.2, NR.sup.3COA, NR.sup.3SO.sub.2A, SO.sub.2N(R.sup.3).sub.2 or S(O).sub.mA, Ar denotes phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R.sup.3).sub.2].sub.nOR.sup.3, [C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, SR.sup.3, NO.sub.2, CN, COOR.sup.3, CON(R.sup.3).sub.2, NR.sup.3COA, NR.sup.3SO.sub.2A, SO.sub.2N(R.sup.3).sub.2, S(O).sub.mA, CO-Het, Het, O[C(R.sup.3).sub.2].sub.n--N(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nHet, NHCOOA, NHCON(R.sup.3).sub.2, NHCOO[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, NHCOO[C(R.sup.3).sub.2].sub.nHet, NHCONH[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, NHCONH[C(R.sup.3).sub.2].sub.nHet, OCONH[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, OCONH[C(R.sup.3).sub.2]Het, CONR.sup.3[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, CONR.sup.3[C(R.sup.3).sub.2].sub.nHet and/or COA, Het denotes a mono-, bi- or tricyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di-, tri-, tetra- or penta-substituted by Hal, A, [C(R.sup.3).sub.2].sub.nOR.sup.3, [C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, SR.sup.3, NO.sub.2, CN, COOR.sup.3, CON(R.sup.3).sub.2, NR.sup.3COA, NR.sup.3SO.sub.2A, SO.sub.2N(R.sup.3).sub.2, S(O).sub.mA, CO-Het.sup.1, [C(R.sup.3).sub.2].sub.nHet.sup.1, O[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nHet.sup.1, NHCOOA, NHCON(R.sup.3).sub.2, NHCOO[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, NHCOO[C(R.sup.3).sub.2].sub.nHet.sup.1, NHCONH[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, NHCONH[C(R.sup.3).sub.2].sub.nHet.sup.1, OCONH[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, OCONH[C(R.sup.3).sub.2].sub.nHet.sup.1, CO-Het.sup.1, CHO, COA, .dbd.S, .dbd.NH, --NA and/or .dbd.O, and where a ring nitrogen is optionally oxidized, Het.sup.1 denotes a monocyclic saturated heterocycle having 1 to 2 N and/or O atoms, which is unsubstituted or mono- or disubstituted by A, OA, OH, Hal and/or .dbd.O, A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms are optionally replaced by F and/or in which one or two non-adjacent CH.sub.2 groups are optionally replaced by O, NH, S, SO, SO.sub.2 and/or by CH.dbd.CH groups, or cyclic alkyl having 3-7 C atoms, Hal denotes F, Cl, Br or I, m denotes 0, 1 or 2, n denotes 0, 1, 2, 3 or 4, and p denotes 1, 2, 3 or 4, or a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof. 2. A method according to claim 1, wherein in the compound of formula I or in a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof R.sup.2 denotes an unsaturated, saturated or aromatic 6-membered heterocycle having 1 to 4 N and/or O atoms, which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R.sup.3).sub.2].sub.nOR.sup.3, N.dbd.CR.sup.3N(R.sup.3).sub.2, CN, COOR.sup.3, [C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, [C(R.sup.3).sub.2].sub.nHet, O[C(R.sup.3).sub.2].sub.pOR.sup.3, O[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nC.ident.C[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.- 2, O[C(R.sup.3).sub.2].sub.nN.sup.+O.sup.-(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nHet, NR.sup.3[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, NR.sup.3[C(R.sup.3).sub.2].sub.nHet, [C(R.sup.3).sub.2].sub.nNHCO[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, [C(R.sup.3).sub.2].sub.nNHCO[C(R.sup.3).sub.2].sub.nHet, CONR.sup.3[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, CONR.sup.3[C(R.sup.3).sub.2].sub.nNR.sup.3COOA, CONR.sup.3[C(R.sup.3).sub.2].sub.nOR.sup.3, CONR.sup.3[C(R.sup.3).sub.2].sub.nHet, COHet, CH.dbd.CH--COOR.sup.3, CH.dbd.CH--N(R.sup.3).sub.2 and/or .dbd.O. 3. A method according to claim 1, wherein in the compound of formula I or in a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof Ar denotes phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di- or trisubstituted by A, Hal, CN, S(O).sub.mA, NR.sup.3COA, CON(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, [C(R.sup.3).sub.2].sub.nOR.sup.3, CONR.sup.3[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2 and/or CONR.sup.3[C(R.sup.3).sub.2].sub.nHet. 4. A method according to claim 1, wherein in the compound of formula I or in a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof R.sup.4, R.sup.4' denote H. 5. A method according to claim 1, wherein in the compound of formula I or in a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof Het denotes a mono-, bi- or tricyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di-, tri-, tetra- or penta-substituted by A, CHO, COOR.sup.S, CON(R.sup.3).sub.2, [C(R.sup.3).sub.2].sub.nHet.sup.1, [C(R.sup.3).sub.2].sub.nOR.sup.3, [C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nHet.sup.1 and/or .dbd.O, and where a ring nitrogen is optionally oxidized. 6. A method according to claim 1, wherein in the compound of formula I or in a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof Het.sup.1 denotes a monocyclic saturated heterocycle having 1 to 2 N and/or O atoms, which is unsubstituted or mono- or disubstituted by A and/or .dbd.O. 7. A method according to claim 1, wherein in the compound of formula I or in a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof A denotes unbranched or branched alkyl having 1-8 C atoms, in which 1-7 H atoms are optionally replaced by F. 8. A method according to claim 1, wherein in the compound of formula I or in a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof R.sup.1 denotes Ar or benzo-2,1,3-thiadiazolyl. 9. A method according to claim 1, wherein in the compound of formula I or in a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof R.sup.3 denotes H, methyl, ethyl or propyl. 10. A method according to claim 1, wherein in the compound of formula I or in a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof R.sup.2 denotes pyrimidinyl, pyridazinyl, pyridinyl, 1,3-oxazinanyl, morpholinyl, piperidinyl or piperazinyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R.sup.3).sub.2].sub.nOR.sup.3, N.dbd.CR.sup.3N(R.sup.3).sub.2, CN, COOR.sup.3, [C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, [C(R.sup.3).sub.2].sub.nHet, O[C(R.sup.3).sub.2].sub.pOR.sup.3, O[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nC.ident.C[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.- 2, O[C(R.sup.3).sub.2]N.sup.+O.sup.-(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nHet, NR.sup.3[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, NR.sup.3[C(R.sup.3).sub.2].sub.nHet, [C(R.sup.3).sub.2].sub.nNHCO[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, [C(R.sup.3).sub.2].sub.nNHCO[C(R.sup.3).sub.2].sub.nHet, CONR.sup.3[C(R.sup.3).sub.2].sub.nNR.sup.3).sub.2, CONR.sup.3[C(R.sup.3).sub.2].sub.nNR.sup.3COOA, CONR.sup.3[C(R.sup.3).sub.2].sub.nOR.sup.3, CONR.sup.3[C(R.sup.3).sub.2].sub.nHet, COHet, CH.dbd.CH--COOR.sup.3, CH.dbd.CH--N(R.sup.3).sub.2 and/or .dbd.O. 11. A method according to claim 1, wherein in the compound of formula I or in a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof Het denotes piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, pyridazinyl, pyrazinyl, benzimidazolyl, benzotriazolyl, indolyl, benzo-1,3-dioxolyl, indazolyl, azabicyclo[3.2.1]octyl, azabicyclo[2.2.2]octyl, imidazolidinyl, azepanyl or benzo-2,1,3-thiadiazolyl, each of which is unsubstituted or mono-, di-, tri-, tetra- or penta-substituted by A, CHO, COOR.sup.3, CON(R.sup.3).sub.2, [C(R.sup.3).sub.2].sub.nHet.sup.1, [C(R.sup.3).sub.2].sub.nOR.sup.3, [C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nHet.sup.1 and/or .dbd.O, and where a ring nitrogen is optionally. 12. A method according to claim 1, wherein in the compound of formula I or in a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof Het.sup.1 denotes pyrrolidine, piperidine, piperazine or morpholine, each of which is unsubstituted or mono- or disubstituted by A and/or .dbd.O. 13. A method according to claim 1, wherein in the compound of formula I or in a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof R.sup.1 denotes Ar or Het, R.sup.2 denotes pyrimidinyl, pyridazinyl, pyridinyl, 1,3-oxazinanyl, morpholinyl, piperidinyl or piperazinyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R.sup.3).sub.2].sub.nOR.sup.3, N.dbd.CR.sup.3N(R.sup.3).sub.2, CN, COOR.sup.3, [C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, [C(R.sup.3).sub.2].sub.nHet, O[C(R.sup.3).sub.2].sub.pOR.sup.3, O[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nC.ident.C[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.- 2, O[C(R.sup.3).sub.2].sub.nN.sup.+O.sup.-(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nHet, NR.sup.3[C(R.sup.3).sub.2].sub.nN(R).sub.2, NR.sup.3[C(R.sup.3).sub.2].sub.nHet, [C(R.sup.3).sub.2].sub.nNHCO[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, [C(R.sup.3).sub.2].sub.nNHCO[C(R.sup.3).sub.2].sub.nHet, CONR.sup.3[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, CONR.sup.3[C(R.sup.3).sub.2].sub.nNR.sup.3COOA, CONR.sup.3[C(R.sup.3).sub.2].sub.nOR.sup.3, CONR.sup.3[C(R.sup.3).sub.2].sub.nHet, COHet, CH.dbd.CH--COOR.sup.3, CH.dbd.CH--N(R.sup.3).sub.2 and/or .dbd.O, R.sup.3 denotes H, methyl, ethyl or propyl, R.sup.4, R.sup.4' denote H, Ar denotes phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di- or trisubstituted by A, Hal, CN, S(O).sub.mA, NR.sup.3COA, CON(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, [C(R.sup.3).sub.2].sub.nOR.sup.3, CONR.sup.3[C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2 and/or CONR.sup.3[C(R.sup.3).sub.2].sub.nHet, Het denotes piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, pyridazinyl, pyrazinyl, benzimidazolyl, benzotriazolyl, indolyl, benzo-1,3-dioxolyl, indazolyl, azabicyclo[3.2.1]octyl, azabicyclo[2.2.2]octyl, imidazolidinyl, azepanyl or benzo-2,1,3-thiadiazolyl, each of which is unsubstituted or mono-, di-, tri-, tetra- or penta-substituted by A, CHO, COOR.sup.3, CON(R.sup.3).sub.2, [C(R.sup.3).sub.2].sub.nHet.sup.1, [C(R.sup.3).sub.2].sub.nOR.sup.3, [C(R.sup.3).sub.2].sub.nN(R.sup.3).sub.2, O[C(R.sup.3).sub.2].sub.nHet.sup.1 and/or .dbd.O, and where a ring nitrogen is optionally oxidized, Het.sup.1 denotes pyrrolidine, piperidine, piperazine or morpholine, each of which is unsubstituted or mono- or disubstituted by A and/or .dbd.O, A denotes unbranched or branched alkyl having 1-8 C atoms, in which 1-7 H atoms are optionally replaced by F, Hal denotes F, Cl, Br or I, m denotes 0, 1 or 2, n denotes 0, 1, 2, 3 or 4, and p denotes 1, 2, 3 or 4. 14. A method for treating a disease in which the inhibition, regulation and/or modulation of kinase signal transduction plays a role or a method for inhibiting Met kinase and/or tyrosine kinase, comprising administering to a patient in need thereof an effective amount of one of the following compounds TABLE-US-00020 No. Name and/or structure "A1" 2-[3-(5-methylpyrimidin-2-yl)benzyl]-6-(3,4,5-trifluorophenyl)- 2H-pyridazin-3-one "A2" 6-(3,5-difluorophenyl)-2-[3-(5-methylpyrimidin-2-yl)benzyl]-2H- pyridazin-3-one "A3" 2-[3-(4-methylpyrimidin-2-yl)benzyl]-6-(3,4,5-trifluorophenyl)- 2H-pyridazin-3-one "A4" 2-(3-pyrimidin-2-ylbenzyl)-6-(3,4,5-trifluorophenyl)-2H- pyridazin-3-one "A5" 4-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]- phenyl}morpholin-3-one "A6" 3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]- phenyl}-1,3-oxazinan-2-one ##STR00211## "A7" 3-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin-1-ylmethyl]- phenyl}-1,3-oxazinan-2-one "A8" 1-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]- phenyl}-3-methyl-6H-pyridazin-6-one "A9" 6-(3,5-difluorophenyl)-2-[3-(5-methylpyridin-2-yl)benzyl]-2H- pyridazin-3-one "A10" 6-(3,5-difluorophenyl)-2-[3-(5-methoxypyridin-2-yl)benzyl]-2H- pyridazin-3-one ##STR00212## "A11" 2-[3-(5-aminopyridin-2-yl)benzyl]-6-(3,5-difluorophenyl)-2H- pyridazin-3-one "A12" 6-(3,5-difluorophenyl)-2-{3-[5-(4-methylpiperazin-1-yl)pyridin-2- yl]benzyl}-2H-pyridazin-3-one "A13" 6-(3,5-difluorophenyl)-2-[3-(4-piperazin-1-ylpyrimidin-2-yl)- benzyl]-2H-pyridazin-3-one "A14" 6-(3,5-difluorophenyl)-2-{3-[5-(4-methylpiperazin-1-ylmethyl)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A15" 3-{1-[3-(5-methylpyrimidin-2-yl)benzyl]-6-oxo-1,6-dihydro- pyridazin-3-yl}benzonitrile "A16" N'-(2-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]- phenyl}pyrimidin-5-yl)-N,N-dimethylformamidine "A17" 2-[3-(5-aminopyrimidin-2-yl)benzyl]-6-(3,5-difluorophenyl)-2H- pyridazin-3-one "A18" 6-(3,5-difluorophenyl)-2-{3-[5-(4-methylpiperazin-1-yl)pyrimidin- 2-yl]benzyl}-2H-pyridazin-3-one "A19" 6-(3,5-difluorophenyl)-2-[3-(5-piperazin-1-ylpyrimidin-2-yl)- benzyl]-2H-pyridazin-3-one "A20" 2-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-6-(3,4,5- trifluorophenyl)-2H-pyridazin-3-one "A21" 6-(3,5-difluorophenyl)-2-[3-(5-hydroxypyrimidin-2-yl)benzyl]-2H- pyridazin-3-one "A22" 6-(3,5-difluorophenyl)-2-{3-[5-(3-dimethylaminopropoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A23" 6-(3,5-difluorophenyl)-2-{3-[5-(1-methylpiperidin-4-yloxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one ##STR00213## "A24" 6-(3,5-difluorophenyl)-2-{3-[5-(3-dimethylaminopropoxy)pyridin- 2-yl]benzyl}-2H-pyridazin-3-one "A25" 2-[3-(5-bromopyrimidin-2-yl)benzyl]-6-(3,5-difluorophenyl)-2H- pyridazin-3-one "A26" 6-(3,5-difluorophenyl)-2-{3-[5-(1-methyl-1H-pyrazol-4-yl)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A27" 6-(3,5-difluorophenyl)-2-{3-[6-(4-methylpiperazin-1-yl)pyridazin- 3-yl]benzyl}-2H-pyridazin-3-one "A28" 6-(3,5-difluorophenyl)-2-{3-[6-(3-dimethylaminopropoxy)- pyridazin-3-yl]benzyl}-2H-pyridazin-3-one "A29" ethyl 2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin-1- ylmethyl]phenyl}pyrimidine-5-carboxylate "A30" ethyl 2-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-yl- methyl]phenyl}pyrimidine-5-carboxylate ##STR00214## "A31" 2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin-1-ylmethyl]- phenyl}pyrimidine-5-carboxylic acid "A32" 2-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]- phenyl}pyrimidine-5-carboxylic acid "A33" N-(2-dimethylaminoethyl)-2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)- 6H-pyridazin-1-ylmethyl]phenyl}pyrimidine-5-carboxamide "A34" ##STR00215## "A35" ##STR00216## "A36" ##STR00217## "A37" ##STR00218## "A38" ##STR00219## "A39" ##STR00220## "A40" ##STR00221## "A41" ##STR00222## "A42" ##STR00223## "A43" ##STR00224## "A44" ##STR00225## "A44a" ##STR00226## "A45" ##STR00227## "A46" ##STR00228## "A47" ##STR00229## "A48" ##STR00230## "A49" ##STR00231## "A50" ##STR00232## "A51" N-[2-(1H-imidazol-4-yl)ethyl]-2-{3-[6-oxo-3-(3,4,5-trifluoro- phenyl)-6H-pyridazin-1-ylmethyl]phenyl}pyrimidine-5- carboxamide "A52" ##STR00233## "A53" ##STR00234## "A54" 2-[3-(5-chloropyrimidin-2-yl)benzyl]-6-(3,4,5-trifluorophenyl)- 2H-pyridazin-3-one "A55" 4-{1-[3-(5-methylpyrimidin-2-yl)benzyl]-6-oxo-1,6-dihydro- pyridazin-3-yl}-N-(3-piperidin-1-ylpropyl)benzamide "A56" 6-(3,5-difluorophenyl)-2-{3-[5-(3-pyrrolidin-1-ylpropoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A57" 6-(3,5-difluorophenyl)-2-(3-{5-[2-(4-methylpiperazin-1-yl)- ethoxy]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one "A58" 6-(3,5-difluorophenyl)-2-[3-(5-dimethylaminomethylpyrimidin-2- yl)benzyl]-2H-pyridazin-3-one "A59" 6-(3,5-difluorophenyl)-2-{3-[4-(methylpiperidin-4-yl- amino)pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one ##STR00235## "A60" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6- (3,4,5-trifluorophenyl)-2H-pyridazin-3-one "A63" ##STR00236## "A64" 2-{3-[5-(2-dimethylaminoethoxy)pyrimidin-2-yl]benzyl}-6-(3,5- difluorophenyl)-2H-pyridazin-3-one "A65" 2-{3-[5-(piperazin-1-yl)pyrimidin-2-yl]benzyl}-6-(3,4,5-trifluoro- phenyl)-2H-pyridazin-3-one "A66" 6-(3,5-difluorophenyl)-2-{3-[5-(1-methylpiperidin-4-ylmethoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A67" 6-(3,5-difluorophenyl)-2-{3-[6-(3-dimethylaminopropylamino)- pyridazin-3-yl]benzyl}pyridazin-3-one "A68" 6-(3,5-difluorophenyl)-2-{3-[6-(2-dimethylaminoethylamino)- pyridazin-3-yl]benzyl}pyridazin-3-one "A69" 6-(3,5-difluorophenyl)-2-{3-[6-(4-dimethylaminobutylamino)- pyridazin-3-yl]benzyl}pyridazin-3-one "A70" 6-(3,5-difluorophenyl)-2-{3-[6-(1-methylpiperidin-4-ylamino)- pyridazin-3-yl]benzyl}pyridazin-3-one "A71" ##STR00237## "A72" ##STR00238## "A73" ##STR00239## "A74" ##STR00240## "A75" 4-(2-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]- phenyl}pyrimidin-5-yl)morpholin-3-one ##STR00241## "A76" N'-(2-{3-[3-(3,4,5-trifluorophenyl)-6-oxo-6H-pyridazin-1-yl- methyl]phenyl}pyrimidin-5-yl)-N,N-dimethylformamidine "A77" 2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin-1-ylmethyl]- phenyl}pyrimidine-5-carbonitrile ##STR00242## "A78" 6-[4-(3-dimethylaminopropoxy)-3,5-difluorophenyl]-2-[3-(5- methylpyrimidin-2-yl)benzyl]-2H-pyridazin-3-one ##STR00243## "A79" 6-benzo-1,2,5-thiadiazol-5-yl-2-[3-(5-methylpyrimidin-2-yl)- benzyl]-2H-pyridazin-3-one ##STR00244## "A80" 6-(3,5-difluorophenyl)-2-[3-(6-oxo-1,6-dihydropyrimidin-2-yl)- benzyl]-2H-pyridazin-3-one "A81" 6-(3,5-difluorophenyl)-2-{3-[4-(3-dimethylaminopropoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A82" 2-[3-(5-aminopyrimidin-2-yl)benzyl]-6-(3,4,5-trifluorophenyl)-2H- pyridazin-3-one "A83" 2-(3-pyrimidin-5-ylbenzyl)-6-(3,4,5-trifluorophenyl)-2H- pyridazin-3-one "A84" ##STR00245## "A85" N-(2-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]- phenyl}pyrimidin-5-yl)-2-dimethylaminoacetamide "A86" 2-[3-(6-methylpyridin-3-yl)benzyl]-6-(3,4,5-trifluorophenyl)-2H- pyridazin-3-one "A87" N-(2-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]- phenyl}pyrimidin-5-yl)-4-dimethylaminobutyramide ##STR00246## "A88" ##STR00247## "A89" ##STR00248## "A90" ##STR00249## "A92" ##STR00250## "A93" 2-[3-(5-aminomethylpyrimidin-2-yl)benzyl]-6-(3,4,5-trifluoro- phenyl)-2H-pyridazin-3-one "A94" 2-(3-pyridin-4-ylbenzyl)-6-(3,4,5-trifluorophenyl)-2H-pyridazin-3- one "A95" N-(2-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]- phenyl}pyrimidin-5-yl)-3-dimethylaminopropionamide ##STR00251## "A96" 3-(4-methylpiperazin-1-yl)-N-(2-{3-[6-oxo-3-(3,4,5-trifluoro- phenyl)-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-ylmethyl)- propionamide ##STR00252## "A97" 2-(4-methylpiperazin-1-yl)-N-(2-{3-[6-oxo-3-(3,4,5-trifluoro- phenyl)-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yl- methyl)acetamide ##STR00253## "A98" 2-methylamino-N-(2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H- pyridazin-1-ylmethyl]phenyl}pyrimidin-5-ylmethyl)acetamide ##STR00254## "A99" 3-dimethylamino-N-(2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H- pyridazin-1-ylmethyl]phenyl}pyrimidin-5-ylmethyl)propionamide ##STR00255## "A100" 2-[3-(5-methylpyrimidin-2-yl)benzyl]-6-(2H-pyrazol-3-yl)-2H- pyridazin-3-one "A101" 6-(3,5-difluorophenyl)-2-[3-(5-hydroxymethylpyrimidin-2-yl)- benzyl]-2H-pyridazin-3-one "A102" 6-(3,5-difluorophenyl)-2-{3-[5-(piperidin-4-yloxy)pyrimidin-2-yl]- benzyl}-2H-pyridazin-3-one "A103" ##STR00256## "A104" ##STR00257## "A105" ##STR00258## "A106" ##STR00259## "A107" ##STR00260## "A108" ##STR00261## "A109" ##STR00262## "A110" ##STR00263## "A111" ##STR00264## "A112" ##STR00265## "A113" ##STR00266## "A114" ##STR00267## "A115" ##STR00268## "A116" ##STR00269## "A117" ##STR00270## "A118" ##STR00271## "A119" 6-(3,5-difluorophenyl)-2-{3-[5-(8-methyl-8-azabicyclo[3.2.1]oct- 3-yloxy)pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one ##STR00272## "A120" ##STR00273## "A121" 6-(3,5-difluorophenyl)-2-{3-[5-((S)-1-methylpyrrolidin-3-yloxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one, ##STR00274## "A122" 6-(3,5-difluorophenyl)-2-{3-[5-((R)-1-methylpyrrolidin-3-yloxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one, "A123" ##STR00275## "A124" ##STR00276## "A125" ##STR00277## "A126" ##STR00278## "A127" 6-(3,5-difluorophenyl)-2-{3-[5-(2-pyrrolidin-1-ylethoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A128" 6-(3,5-difluorophenyl)-2-{3-[5-(3-morpholin-4-ylpropoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A129" ##STR00279## "A130" 6-(3,5-difluorophenyl)-2-{3-[5-(2-morpholin-4-ylethoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one, hydrochloride "A131" ##STR00280## "A132" 6-(3,5-difluorophenyl)-2-{3-[5-(4-methylaminobutoxy)pyrimidin- 2-yl]benzyl}-2H-pyridazin-3-one "A133" 6-(3,5-difluorophenyl)-2-{3-[5-(3-methylaminopropoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A134" 6-(3,5-difluorophenyl)-2-{3-[5-(pyrrolidin-3-ylmethoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A135" 6-(3,5-difluorophenyl)-2-{3-[5-(3-ethylaminopropoxy)pyrimidin- 2-yl]benzyl}-2H-pyridazin-3-one "A136" 2-{3-[5-(2-aminoethoxy)pyrimidin-2-yl]benzyl}-6-(3,5-difluoro- phenyl)-2H-pyridazin-3-one "A137" 6-(3,5-difluorophenyl)-2-{3-[5-(piperidin-3-yloxy)pyrimidin-2-yl]- benzyl}-2H-pyridazin-3-one "A138" 6-(3,5-difluorophenyl)-2-{3-[5-(piperidin-4-ylmethoxy)pyrimidin- 2-yl]benzyl}-2H-pyridazin-3-one "A139" 6-(3,5-difluorophenyl)-2-{3-[5-(pyrrolidin-3-yloxy)pyrimidin-2- yl]benzyl}-2H-pyridazin-3-one "A140" 6-(3,5-difluorophenyl)-2-{3-[5-((S)-pyrrolidin-3-yloxy)pyrimidin- 2-yl]benzyl}-2H-pyridazin-3-one "A141" 6-(3,5-difluorophenyl)-2-{3-[5-((R)-pyrrolidin-3-yloxy)pyrimidin- 2-yl]benzyl}-2H-pyridazin-3-one "A142" 2-{3-[5-(piperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6-pyridin-4-yl- 2H-pyridazin-3-one ##STR00281## "A143" 4-(6-oxo-1-{3-[5-(piperidin-4-yloxy)pyrimidin-2-yl]benzyl}-1,6- dihydropyridazin-3-yl)benzonitrile ##STR00282## "A144" 3-(6-oxo-1-{3-[5-(piperidin-4-yloxy)pyrimidin-2-yl]benzyl}-1,6- dihydropyridazin-3-yl)benzonitrile "A145" 6-(3,5-difluorophenyl)-2-{3-[5-(2-piperazin-1-ylethoxy)pyrimidin- 2-yl]benzyl}-2H-pyridazin-3-one "A146" 6-(3,5-difluorophenyl)-2-{3-[5-(piperidin-4-yloxy)pyrimidin-2-yl]- benzyl}-2H-pyridazin-3-one "A147" 3-(6-oxo-1-{3-[5-(2-piperazin-1-ylethoxy)pyrimidin-2-yl]benzyl}- 1,6-dihydropyridazin-3-yl)benzonitrile "A148" 6-(3-fluorophenyl)-2-{3-[5-(piperidin-4-ylmethoxy)pyrimidin-2- yl]benzyl}-2H-pyridazin-3-one "A149" 2-{3-[5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyrimidin-2-yl]benzyl}- 6-(3,4,5-trifluorophenyl)-2H-pyridazin-3-one ##STR00283## "A150" 3-(6-oxo-1-{3-[5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyrimidin-2- yl]benzyl}1,6-dihydropyridazin-3-yl)benzonitrile ##STR00284## "A151" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one ##STR00285## "A152" 6-(3-methoxyphenyl)-2-{3-[5-(1-piperidin-4-yl-1H-pyrazol-4-yl)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A153" 6-(3-fluorophenyl)-2-{3-[5-(1-piperidin-4-yl-1H-pyrazol-4-yl)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A154" 6-(3,5-difluorophenyl)-2-{3-[5-(1H-pyrazol-4-yl)pyrimidin-2-yl]- benzyl}-2H-pyridazin-3-one ##STR00286## "A155" 6-(3,5-difluorophenyl)-2-(3-{5-[1-(2-methylaminoethyl)-1H- pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one, ##STR00287## "A156" 6-(3-chlorophenyl)-2-{3-[5-(1-piperidin-4-yl-1H-pyrazol-4-yl)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one ##STR00288## "A157" ##STR00289## "A158" 6-(3,5-difluorophenyl)-2-(3-{5-[1-(3-methylaminopropyl)-1H- pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one ##STR00290## "A159" 3-[1-(3-{5-[1-(2-methylaminoethyl)-1H-pyrazol-4-yl]pyrimidin-2- yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile ##STR00291## "A160" 6-(3,5-difluorophenyl)-2-(3-{5-[1-(2-piperazin-1-ylethyl)-1H- pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one ##STR00292## "A161" 3-(6-oxo-1-{3-[5-(1H-pyrazol-4-yl)pyrimidin-2-yl]benzyl}-1,6- dihydropyridazin-3-yl)benzonitrile ##STR00293## "A162" 3-[6-oxo-1-(3-{5-[1-(2-piperazin-1-ylethyl)-1H-pyrazol-4-yl]- pyrimidin-2-yl}benzyl)-1,6-dihydropyridazin-3-yl]benzonitrile ##STR00294## "A163" N-(4-dimethylaminobutyl)-2-[3-(6-oxo-3-pyridin-4-yl-6H- pyridazin-1-ylmethyl)phenyl]pyrimidine-5-carboxamide ##STR00295## "A164" N-(4-dimethylaminobutyl)-2-{3-[3-(4-cyanophenyl)-6-oxo-6H- pyridazin-1-ylmethyl]phenyl}pyrimidine-5-carboxamide ##STR00296## "A165" ##STR00297## "A166" ##STR00298## "A167" ##STR00299## "A168" ##STR00300## "A169" 6-(1-methyl-1H-pyrazol-4-yl)-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)- 1H-pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one ##STR00301## "A170" 6-(3,5-difluorophenyl)-2-(3-{5-[1-(2-morpholin-4-ylethyl)-1H- pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one ##STR00302## "A171" 6-(3,5-difluorophenyl)-2-(3-{5-[1-(2-dimethylaminoethyl)-1H- pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one ##STR00303## "A172" 6-(3,5-difluorophenyl)-2-(3-{5-[1-(3-dimethylaminopropyl)-1H- pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one "A173" 6-(3,5-difluorophenyl)-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H- pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one "A174" 3-[1-(3-{5-[1-(2-morpholin-4-ylethyl)-1H-pyrazol-4-yl]pyrimidin- 2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile ##STR00304## "A175" 2-(3-{5-[1-(2-morpholin-4-ylethyl)-1H-pyrazol-4-yl]pyrimidin-2- yl}benzyl)-6-pyridin-3-yl-2H-pyridazin-3-one ##STR00305## "A176" 6-(1-methyl-1H-pyrazol-4-yl)-2-(3-{5-[1-(2-morpholin-4-ylethyl)- 1H-pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one ##STR00306## "A177" 2-(3-{5-[1-(2-morpholin-4-ylethyl)-1H-pyrazol-4-yl]pyrimidin-2- yl}benzyl)-6-pyridin-4-yl-2H-pyridazin-3-one "A178" 6-(4-methanesulfonylphenyl)-2-(3-{5-[1-(2-morpholin-4-ylethyl)- 1H-pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one "A179" 6-pyridin-4-yl-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4- yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one "A180" 4-[6-oxo-1-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]- pyrimidin-2-yl}benzyl)-1,6-dihydropyridazin-3-yl]benzonitrile ##STR00307## "A181" 2-(3-{5-[1-(2-morpholin-4-ylethyl)-1H-pyrazol-4-yl]pyrimidin-2- yl}benzyl)-6-pyridin-4-yl-2H-pyridazin-3-one "A182" ##STR00308## "A183" 6-(4-methanesulfonylphenyl)-2-(3-{5-[1-(2-morpholin-4-ylethyl)- 1H-pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one "A184" 6-(5-methyloxazol-2-yl)-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H- pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one ##STR00309## "A185" 6-(3-fluorophenyl)-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol- 4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one "A186" 6-(1-propyl-1H-pyrazol-4-yl)-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)- 1H-pyrazol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one ##STR00310## "A187" 2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]pyrimidin-2- yl}benzyl)-6-thiophen-3-yl-2H-pyridazin-3-one ##STR00311## "A188" ##STR00312## "A188a" ##STR00313## "A189" 3-(1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6- oxo-1,6-dihydropyridazin-3-yl)benzonitrile "A190" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(1- methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one ##STR00314## "A191" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(3- fluorophenyl)-2H-pyridazin-3-one "A192" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6- thiazol-2-yl-2H-pyridazin-3-one "A193" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6- phenyl-2H-pyridazin-3-one "A194" 4-(1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6- oxo-1,6-dihydropyridazin-3-yl)benzonitrile "A195" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-p- tolyl-2H-pyridazin-3-one "A196" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(2H- pyrazol-3-yl)-2H-pyridazin-3-one "A197" 6-(3,4-difluorophenyl)-2-{3-[5-(3-dimethylaminopropoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A198" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(4- methanesulfonylphenyl)-2H-pyridazin-3-one "A199" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-[4- (5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2H-pyridazin-3-one "A200" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6- pyridin-4-yl-2H-pyridazin-3-one "A201" 6-(3-bromophenyl)-2-{3-[5-(3-dimethylaminopropoxy)pyrimidin- 2-yl]benzyl}-2H-pyridazin-3-one "A202" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6- (3,4,5-trifluorophenyl)-2H-pyridazin-3-one "A203" 6-(3,5-dimethoxyphenyl)-2-{3-[5-(3-dimethylaminopropoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A204" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(3- fluoro-4-methoxyphenyl)-2H-pyridazin-3-one "A205" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(4- methoxyphenyl)-2H-pyridazin-3-one "A206" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(3- trifluoromethylphenyl)-2H-pyridazin-3-one, "A207" 6-(3-chlorophenyl)-2-{3-[5-(3-dimethylaminopropoxy)pyrimidin- 2-yl]benzyl}-2H-pyridazin-3-one "A208" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6- pyridin-3-yl-2H-pyridazin-3-one "A209" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(1- methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A210" 6-(3-chloro-5-fluorophenyl)-2-{3-[5-(3-dimethylaminopropoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A211" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(4- fluoro-3-methoxyphenyl)-2H-pyridazin-3-one "A212" 6-(4-chlorophenyl)-2-{3-[5-(3-dimethylaminopropoxy)pyrimidin- 2-yl]benzyl}-2H-pyridazin-3-one "A213" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(4- fluorophenyl)-2H-pyridazin-3-one "A214" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6- thiophen-2-yl-2H-pyridazin-3-one "A215" N-[4-(1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}- 6-oxo-1,6-dihydropyridazin-3-yl)phenyl]acetamide ##STR00315## "A216" 6-(3,4-dimethoxyphenyl)-2-{3-[5-(3-dimethylaminopropoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A217" 6-benzo-1,2,5-thiadiazol-5-yl-2-{3-[5-(3-dimethylaminopropoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one ##STR00316## "A218" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6- furan-3-yl-2H-pyridazin-3-one "A219" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(5- methyl-1,2,4-oxadiazol-3-yl)-2H-pyridazin-3-one "A220" 4-(1-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6- oxo-1,6-dihydropyridazin-3-yl)benzonitrile "A221" 3-(1-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6- oxo-1,6-dihydropyridazin-3-yl)benzonitrile "A222" 3-(1-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-6- oxo-1,6-dihydropyridazin-3-yl)benzonitrile "A223" 2-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6- pyridin-4-yl-2H-pyridazin-3-one "A224" 6-(4-methanesulfonylphenyl)-2-{3-[5-(1-methylpiperidin-4-yloxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A225" methyl 5-(1-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]- benzyl}-6-oxo-1,6-dihydropyridazin-3-yl)thiophene-2-carboxylate ##STR00317## "A226" 2-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6-(1- methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A227" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(5- oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-2H-pyridazin-3-one ##STR00318## "A228" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6- piperazin-1-yl-2H-pyridazin-3-one ##STR00319## "A229" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-ylethoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A230" 2-[3-(5-bromopyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4- yl)-2H-pyridazin-3-one "A231" 2-[3-(5-hydroxypyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4- yl)-2H-pyridazin-3-one "A235" 6-(3-fluorophenyl)-2-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2- yl]benzyl}-2H-pyridazin-3-one "A237" 2-{3-[5-(1-methylpiperidin-4-ylmethoxy)pyrimidin-2-yl]benzyl}- 6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A238" 2-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6-(1- methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A239" 2-[3-(5-methoxypyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4- yl)-2H-pyridazin-3-one "A240" 2-{3-[5-(3-methoxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl- 1H-pyrazol-4-yl)-2H-pyridazin-3-one "A241" 2-{3-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl- 1H-pyrazol-4-yl)-2H-pyridazin-3-one "A242" 2-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-6-(1- propyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A243" 2-(3-{5-[2-(4-methylpiperazin-1-yl)ethoxy]pyrimidin-2-yl}- benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A244" 2-(3-{5-[2-(4-methyl-3-oxopiperazin-1-yl)ethoxy]pyrimidin-2-yl}- benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one ##STR00320## "A245" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(3-morpholin-4-ylpropoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A246" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-ylpropoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one ##STR00321## "A247" 2-{3-[5-(1-methyl-2-morpholin-4-ylethoxy)pyrimidin-2-yl]- benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one ##STR00322## "A248" 2-{3-[5-(2-dimethylaminoethoxy)pyrimidin-2-yl]benzyl}-6-(1- methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A249" 2-{3-[5-(2-methyl-3-morpholin-4-ylpropoxy)pyrimidin-2-yl]- benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one ##STR00323## "A250" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-pyrrolidin-1-ylethoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A251" 2-[3-(5-ethoxypyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4- yl)-2H-pyridazin-3-one "A252" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-2-oxo- ethoxy)pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one ##STR00324## "A253" 6-(3-chlorophenyl)-2-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2- yl]benzyl}-2H-pyridazin-3-one "A254" ##STR00325## "A255" ##STR00326## "A256" ##STR00327## "A257" 3-(1-{3-[5-(1-methylpiperidin-4-ylmethoxy)pyrimidin-2-yl]- benzyl}-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile "A258" 2-[3-(5-bromopyridin-2-yl)benzyl]-6-(3,5-difluorophenyl)-2H- pyridazin-3-one "A259" 6-(3,5-difluorophenyl)-2-{3-[5-(1-piperidin-4-yl-1H-pyrazol-4-yl)- pyridin-2-yl]benzyl}-2H-pyridazin-3-one "A260" 3-(1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6- oxo-1,6-dihydropyridazin-3-yl)benzamide "A261" ##STR00328## "A262" 3-{1-[3-(5-bromopyrimidin-2-yl)benzyl]-6-oxo-1,6-dihydro- pyridazin-3-yl}benzonitrile "A263" 3-{1-[3-(5-hydroxypyrimidin-2-yl)benzyl]-6-oxo-1,6-dihydro- pyridazin-3-yl}benzonitrile "A264" 3-(6-oxo-1-{3-[5-(piperidin-4-ylmethoxy)pyrimidin-2-yl]benzyl}- 1,6-dihydropyridazin-3-yl)benzonitrile "A265" tert-butyl 4-(2-{3-[3-(3-cyanophenyl)-6-oxo-6H-pyridazin-1- ylmethyl]phenyl}pyrimidin-5-yloxymethyl)piperidine-1- carboxylate "A266" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(piperidin-4-yloxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A267" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(piperidin-4-ylmethoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A268" 3-(1-{3-[5-(3-methylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo- 1,6-dihydropyridazin-3-yl)benzonitrile ##STR00329## "A269" 3-[1-(3-{5-[2-(4-methyl-3-oxopiperazin-1-yl)ethoxy]pyrimidin-2- yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile ##STR00330## "A270" 3-[1-(3-{5-[2-(4-methylpiperazin-1-yl)ethoxy]pyrimidin-2-yl}- benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile "A271" 3-(1-{3-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6- dihydropyridazin-3-yl)benzonitrile "A272" 3-(1-{3-[5-(3-methoxypropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6- dihydropyridazin-3-yl)benzonitrile "A273" 6-(3-fluorophenyl)-2-{3-[5-(1-methylpiperidin-4-ylmethoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A274" 2-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6-(1- propyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A275" 6-(3-chlorophenyl)-2-{3-[5-(1-methylpiperidin-4-ylmethoxy)- pyrimidin-2-yl]benzyl}-2H-pyridazin-3-one "A276" ##STR00331## "A276a" ##STR00332## "A277" 5-(1-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6- oxo-1,6-dihydropyridazin-3-yl)thiophene-2-carboxylic acid "A278" 5-(1-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6- oxo-1,6-dihydropyridazin-3-yl)thiophene-2-carboxamide "A279" N-methyl-5-(1-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]- benzyl}-6-oxo-1,6-dihydropyridazin-3-yl)thiophene-2- carboxamide "A280" 2-[3-(5-aminopyrazin-2-yl)benzyl]-6-(3,5-difluorophenyl)-2H- pyridazin-3-one "A281" 6-(3,5-difluorophenyl)-2-[3-(6-methylpyridazin-3-yl)benzyl]-2H- pyridazin-3-one "A282" 2-[3-(6-aminopyridazin-3-yl)benzyl]-6-(3,5-difluorophenyl)-2H- pyridazin-3-one "A283" methyl (E)-3-(2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin- 1-ylmethyl]phenyl}pyrimidin-5-yl)acrylate "A284" 2-{3-[5-((E)-3-aminopropenyl)pyrimidin-2-yl]benzyl}-6-(3,4,5- trifluorophenyl)-2H-pyridazin-3-one "A285" 2-{3-[5-(3-aminopropyl)pyrimidin-2-yl]benzyl}-6-(3,4,5-trifluoro- phenyl)-2H-pyridazin-3-one "A286" 2-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-6-(1- methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A287" 3-(1-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-6-oxo- 1,6-dihydropyridazin-3-yl)benzonitrile "A288" 3-{6-oxo-1-[3-(5-piperazin-1-ylpyrimidin-2-yl)benzyl]-1,6- dihydropyridazin-3-yl}benzonitrile "A289" 6-(4-methanesulfonylphenyl)-2-[3-(5-piperazin-1-ylpyrimidin-2- yl)benzyl]-2H-pyridazin-3-one "A290" 4-{1-[3-(5-aminopyrimidin-2-yl)benzyl]-6-oxo-1,6-dihydro- pyridazin-3-yl}benzonitrile "A291" 3-{1-[3-(5-aminopyrimidin-2-yl)benzyl]-6-oxo-1,6-dihydro- pyridazin-3-yl}benzonitrile "A292" 6-(1-methyl-1H-pyrazol-4-yl)-2-[3-(5-piperazin-1-ylpyrimidin-2- yl)benzyl]-2H-pyridazin-3-one "A293" 2-[3-(5-aminopyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4- yl)-2H-pyridazin-3-one "A294" 2-{3-[5-(2-hydroxyethoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl- 1H-pyrazol-4-yl)-2H-pyridazin-3-one "A295" 3-(1-{3-[5-(3-hydroxypropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6- dihydropyridazin-3-yl)benzonitrile "A296" 3-(1-{3-[5-(2-hydroxyethoxy)pyrimidin-2-yl]benzyl}6-oxo-1,6- dihydropyridazin-3-yl)benzonitrile "A297" 2-{3-[5-(3-hydroxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl- 1H-pyrazol-4-yl)-2H-pyridazin-3-one "A298" 3-[1-(1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]phenyl}- ethyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile "A299" 6-(3,5-difluorophenyl)-2-(1-{3-[5-(3-dimethylaminopropoxy)- pyrimidin-2-yl]phenyl}ethyl)-2H-pyridazin-3-one "A300" 6-(3,5-difluorophenyl)-2-((R)-1-{3-[5-(3-dimethylaminopropoxy)- pyrimidin-2-yl]phenyl}ethyl)-2H-pyridazin-3-one "A301" 6-(3,5-difluorophenyl)-2-((S)-1-{3-[5-(3-dimethylaminopropoxy)- pyrimidin-2-yl]phenyl}ethyl)-2H-pyridazin-3-one "A302" 3-(1-{3-[5-(1-methyl-1-oxypiperidin-4-ylmethoxy)pyrimidin-2-yl]- benzyl}-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile "A303" 3-(1-{3-[5-(1-formylpiperidin-4-ylmethoxy)pyrimidin-2-yl]- benzyl}-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile "A304" ##STR00333## "A305" ##STR00334## "A306" ##STR00335## "A307" ##STR00336## "A308" ##STR00337## "A309" ##STR00338## "A310" ##STR00339## "A311" ##STR00340## "A312" ##STR00341## "A313" ##STR00342## "A314" ##STR00343## or a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof. 15. A method according to claim 14, wherein one of the following compounds is administered TABLE-US-00021 No. Name and/or structure "A1" 2-[3-(5-methylpyrimidin-2-yl)benzyl]-6-(3,4,5-trifluorophenyl)-2H-pyr- idazin-3-one "A2" 6-(3,5-difluorophenyl)-2-[3-(5-methylpyrimidin-2-yl)benzyl]-2H-pyrida- zin-3-one "A3" 2-[3-(4-methylpyrimidin-2-yl)benzyl]-6-(3,4,5-trifluorophenyl)-2H-pyr- idazin-3-one "A4" 2-(3-pyrimidin-2-ylbenzyl)-6-(3,4,5-trifluorophenyl)-2H-pyridazin-3-o- ne "A13" 6-(3,5-difluorophenyl)-2-[3-(4-piperazin-1-ylpyrimidin-2-yl)-benzyl]- -2H-pyridazin-3-one "A14" 6-(3,5-difluorophenyl)-2-{3-[5-(4-methylpiperazin-1-ylmethyl)-pyrimi- din-2-yl]benzyl}-2H-pyridazin-3-one "A15" 3-{1-[3-(5-methylpyrimidin-2-yl)benzyl]-6-oxo-1,6-dihydro-pyridazin-- 3-yl}benzonitrile "A16" N'-(2-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phen- yl}pyrimidin-5-yl)-N,N-dimethylformamidine "A17" 2-[3-(5-aminopyrimidin-2-yl)benzyl]-6-(3,5-difluorophenyl)-2H-pyrida- zin-3-one "A18" 6-(3,5-difluorophenyl)-2-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-y- l]benzyl}-2H-pyridazin-3-one "A19" 6-(3,5-difluorophenyl)-2-[3-(5-piperazin-1-ylpyrimidin-2-yl)-benzyl]- -2H-pyridazin-3-one "A20" 2-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-6-(3,4,5-trif- luorophenyl)-2H-pyridazin-3-one "A21" 6-(3,5-difluorophenyl)-2-[3-(5-hydroxypyrimidin-2-yl)benzyl]-2H-pyri- dazin-3-one "A22" 6-(3,5-difluorophenyl)-2-{3-[5-(3-dimethylaminopropoxy)-pyrimidin-2-- yl]benzyl}-2H-pyridazin-3-one "A23" ##STR00344## "A25" 2-[3-(5-bromopyrimidin-2-yl)benzyl]-6-(3,5-difluorophenyl)-2H-pyrida- zin-3-one "A26" 6-(3,5-difluorophenyl)-2-{3-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-- 2-yl]benzyl}-2H-pyridazin-3-one "A29" ethyl 2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin-1-ylmethyl]phenyl}pyri- midine-5-carboxylate "A30" ##STR00345## "A31" 2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin-1-ylmethyl]-pheny- l}pyrimidine-5-carboxylic acid "A32" 2-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phenyl}p- yrimidine-5-carboxylic acid "A33" N-(2-dimethylaminoethyl)-2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H-py- ridazin-1-ylmethyl]phenyl}pyrimidine- 5-carboxamide "A34" ##STR00346## "A35" ##STR00347## "A36" ##STR00348## "A37" ##STR00349## "A38" ##STR00350## "A39" ##STR00351## "A40" ##STR00352## "A41" ##STR00353## "A42" ##STR00354## "A43" ##STR00355## "A44" ##STR00356## "A44a" ##STR00357## "A45" ##STR00358## "A46" ##STR00359## "A47" ##STR00360## "A48" ##STR00361## "A49" ##STR00362## "A50" ##STR00363## "A51" N-[2-(1H-imidazol-4-yl)ethyl]-2-{3-[6-oxo-3-(3,4,5-trifluoro-phenyl)- -6H-pyridazin-1-ylmethyl]phenyl}pyrimidine-5- carboxamide "A52" ##STR00364## "A53" ##STR00365## "A54" 2-[3-(5-chloropyrimidin-2-yl)benzyl]-6-(3,4,5-trifluorophenyl)-2H-py- ridazin-3-one "A55" 4-{1-[3-(5-methylpyrimidin-2-yl)benzyl]-6-oxo-1,6-dihydro-pyridazin-- 3-yl}-N-(3-piperidin-1-ylpropyl)benzamide "A56" 6-(3,5-difluorophenyl)-2-{3-[5-(3-pyrrolidin-1-ylpropoxy)-pyrimidin-- 2-yl]benzyl}-2H-pyridazin-3-one "A57" 6-(3,5-difluorophenyl)-2-(3-{5-[2-(4-methylpiperazin-1-yl)-ethoxy]py- rimidin-2-yl}benzyl)-2H-pyridazin-3-one "A58" 6-(3,5-difluorophenyl)-2-[3-(5-dimethylaminomethylpyrimidin-2-yl)ben- zyl]-2H-pyridazin-3-one "A59" ##STR00366## "A60" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(3,4,5-trif- luorophenyl)-2H-pyridazin-3-one "A63" ##STR00367## "A64" 2-{3-[5-(2-dimethylaminoethoxy)pyrimidin-2-yl]benzyl}-6-(3,5-difluor- ophenyl)-2H-pyridazin-3-one "A65" 2-{3-[5-(piperazin-1-yl)pyrimidin-2-yl]benzyl}-6-(3,4,5-trifluoro-ph- enyl)-2H-pyridazin-3-one "A66" 6-(3,5-difluorophenyl)-2-{3-[5-(1-methylpiperidin-4-ylmethoxy)-pyrim- idin-2-yl]benzyl}-2H-pyridazin-3-one "A71" ##STR00368## "A72" ##STR00369## "A73" ##STR00370## "A74" ##STR00371## "A75" ##STR00372## "A76" N'-(2-{3-[3-(3,4,5-trifluorophenyl)-6-oxo-6H-pyridazin-1-yl-methyl]p- henyl}pyrimidin-5-yl)-N,N-dimethylformamidine "A77" ##STR00373## "A78" ##STR00374## "A79" ##STR00375## "A80" 6-(3,5-difluorophenyl)-2-[3-(6-oxo-1,6-dihydropyrimidin-2-yl)-benzyl- ]-2H-pyridazin-3-one "A81" 6-(3,5-difluorophenyl)-2-{3-[4-(3-dimethylaminopropoxy)-pyrimidin-2-- yl]benzyl}-2H-pyridazin-3-one "A82" 2-[3-(5-aminopyrimidin-2-yl)benzyl]-6-(3,4,5-trifluorophenyl)-2H-pyr- idazin-3-one "A83" 2-(3-pyrimidin-5-ylbenzyl)-6-(3,4,5-trifluorophenyl)-2H-pyridazin-3-- one "A84" ##STR00376## "A85" N-(2-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-pheny- l}pyrimidin-5-yl)-2-dimethylaminoacetamide "A87" ##STR00377## "A88" ##STR00378## "A89" ##STR00379## "A90" ##STR00380## "A92" ##STR00381## "A93" 2-[3-(5-aminomethylpyrimidin-2-yl)benzyl]-6-(3,4,5-trifluorophenyl)-- 2H-pyridazin-3-one "A95" ##STR00382## "A96" ##STR00383## "A97" ##STR00384## "A98" ##STR00385## "A99" ##STR00386## "A100" 2-[3-(5-methylpyrimidin-2-yl)benzyl]-6-(2H-pyrazol-3-yl)-2H-pyridaz- in-3-one "A101" 6-(3,5-difluorophenyl)-2-[3-(5-hydroxymethylpyrimidin-2-yl)-benzyl]- -2H-pyridazin-3-one "A102" 6-(3,5-difluorophenyl)-2-{3-[5-(piperidin-4-yloxy)pyrimidin-2-yl]-b- enzyl}-2H-pyridazin-3-one "A103" ##STR00387## "A104" ##STR00388## "A105" ##STR00389## "A106" ##STR00390## "A107" ##STR00391## "A108" ##STR00392## "A109" ##STR00393## "A110" ##STR00394## "A111" ##STR00395## "A112" ##STR00396## "A113" ##STR00397## "A114" ##STR00398## "A115" ##STR00399## "A116" ##STR00400## "A117" ##STR00401## "A118" ##STR00402## "A119" ##STR00403## "A120" ##STR00404## "A121" ##STR00405## "A122" 6-(3,5-difluorophenyl)-2-{3-[5-((R)-1-methylpyrrolidin-3-yloxy)-pyr- imidin-2-yl]benzyl}-2H-pyridazin-3-one, "A123" ##STR00406## "A124" ##STR00407## "A125" ##STR00408## "A126" ##STR00409## "A127" 6-(3,5-difluorophenyl)-2-{3-[5-(2-pyrrolidin-1-ylethoxy)-pyrimidin-- 2-yl]benzyl}-2H-pyridazin-3-one "A128" 6-(3,5-difluorophenyl)-2-{3-[5-(3-morpholin-4-ylpropoxy)-pyrimidin-- 2-yl]benzyl}-2H-pyridazin-3-one "A129" ##STR00410## "A130" 6-(3,5-difluorophenyl)-2-{3-[5-(2-morpholin-4-ylethoxy)-pyrimidin-2- -yl]benzyl}-2H-pyridazin-3-one, hydrochloride "A131" ##STR00411## "A132" 6-(3,5-difluorophenyl)-2-{3-[5-(4-methylaminobutoxy)pyrimidin-2-yl]- benzyl}-2H-pyridazin-3-one "A133" 6-(3,5-difluorophenyl)-2-{3-[5-(3-methylaminopropoxy)-pyrimidin-2-y- l]benzyl}-2H-pyridazin-3-one "A134" 6-(3,5-difluorophenyl)-2-{3-[5-(pyrrolidin-3-ylmethoxy)-pyrimidin-2- -yl]benzyl}-2H-pyridazin-3-one "A135" 6-(3,5-difluorophenyl)-2-{3-[5-(3-ethylaminopropoxy)pyrimidin-2-yl]- benzyl}-2H-pyridazin-3-one "A136" 2-{3-[5-(2-aminoethoxy)pyrimidin-2-yl]benzyl}-6-(3,5-difluorophenyl- )-2H-pyridazin-3-one "A137" 6-(3,5-difluorophenyl)-2-{3-[5-(piperidin-3-yloxy)pyrimidin-2-yl]-b- enzyl}-2H-pyridazin-3-one "A138" 6-(3,5-difluorophenyl)-2-{3-[5-(piperidin-4-ylmethoxy)pyrimidin-2-y- l]benzyl}-2H-pyridazin-3-one "A139" 6-(3,5-difluorophenyl)-2-{3-[5-(pyrrolidin-3-yloxy)pyrimidin-2-yl]b- enzyl}-2H-pyridazin-3-one "A140" 6-(3,5-difluorophenyl)-2-{3-[5-((S)-pyrrolidin-3-yloxy)pyrimidin-2-- yl]benzyl}-2H-pyridazin-3-one "A141" 6-(3,5-difluorophenyl)-2-{3-[5-((R)-pyrrolidin-3-yloxy)pyrimidin-2-- yl]benzyl}-2H-pyridazin-3-one "A142" ##STR00412## "A143" ##STR00413## "A144" 3-(6-oxo-1-{3-[5-(piperidin-4-yloxy)pyrimidin-2-yl]benzyl}1,6-dihyd- ropyridazin-3-yl)benzonitrile "A145" 6-(3,5-difluorophenyl)-2-{3-[5-(2-piperazin-1-ylethoxy)pyrimidin-2-- yl]benzyl}-2H-pyridazin-3-one "A146" 6-(3,5-difluorophenyl)-2-{3-[5-(piperidin-4-yloxy)pyrimidin-2-yl]-b- enzyl}-2H-pyridazin-3-one "A147" 3-(6-oxo-1-{3-[5-(2-piperazin-1-ylethoxy)pyrimidin-2-yl]benzyl}-1,6- -dihydropyridazin-3-yl)benzonitrile "A148" 6-(3-fluorophenyl)-2-{3-[5-(piperidin-4-ylmethoxy)pyrimidin-2-yl]be- nzyl}-2H-pyridazin-3-one "A149" ##STR00414## "A150" ##STR00415## "A151" ##STR00416## "A152" 6-(3-methoxyphenyl)-2-{3-[5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyri- midin-2-yl]benzyl}-2H-pyridazin-3-one "A153" 6-(3-fluorophenyl)-2-{3-[5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyrim- idin-2-yl]benzyl}-2H-pyridazin-3-one "A154" ##STR00417## "A155" ##STR00418## "A156" ##STR00419## "A157" ##STR00420## "A158" ##STR00421## "A159" ##STR00422## "A160" ##STR00423## "A161" ##STR00424## "A162" ##STR00425## "A163" ##STR00426## "A164" ##STR00427## "A165" ##STR00428## "A166" ##STR00429## "A167" ##STR00430## "A168" ##STR00431## "A169" ##STR00432## "A170" ##STR00433## "A171" ##STR00434## "A172" 6-(3,5-difluorophenyl)-2-(3-{5-[1-(3-dimethylaminopropyl)-1H-pyrazo- l-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one "A173" 6-(3,5-difluorophenyl)-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyraz- ol-4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one "A174" ##STR00435## "A175" ##STR00436## "A176" ##STR00437## "A177" 2-(3-{5-[1-(2-morpholin-4-ylethyl)-1H-pyrazol-4-yl]pyrimidin-2-yl}b- enzyl)-6-pyridin-4-yl-2H-pyridazin-3-one "A178" 6-(4-methanesulfonylphenyl)-2-(3-{5-[1-(2-morpholin-4-ylethyl)-1H-p- yrazol-4-yl]pyrimidin-2-yl}benzyl)-2H- pyridazin-3-one "A179" 6-pyridin-4-yl-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]- pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one "A180" ##STR00438## "A181" 2-(3-{5-[1-(2-morpholin-4-ylethyl)-1H-pyrazol-4-yl]pyrimidin-2-yl}b- enzyl)-6-pyridin-4-yl-2H-pyridazin-3-one "A182" ##STR00439## "A183" 6-(3-methanesulfonylphenyl)-2-(3-{5-[1-(2-morpholin-4-ylethyl)-1H-p- yrazol-4-yl]pyrimidin-2-yl}benzyl)-2H- pyridazin-3-one "A184" ##STR00440## "A185" 6-(3-fluorophenyl)-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol- 4-yl]pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one "A186" ##STR00441## "A187" ##STR00442## "A188" ##STR00443## "A188a" ##STR00444## "A189" 3-(1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6- -dihydropyridazin-3-yl)benzonitrile "A190" ##STR00445## "A191" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(3-fluorop- henyl)-2H-pyridazin-3-one "A192" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-thiazol-2-- yl-2H-pyridazin-3-one "A193" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-phenyl-2H-- pyridazin-3-one "A194" 4-(1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6- -dihydropyridazin-3-yl)benzonitrile "A195" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-p-tolyl-2H- -pyridazin-3-one "A196" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(2H-pyrazo- l-3-yl)-2H-pyridazin-3-one "A197" 6-(3,4-difluorophenyl)-2-{3-[5-(3-dimethylaminopropoxy)-pyrimidin-2- -yl]benzyl}-2H-pyridazin-3-one "A198" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(4-methane- sulfonylphenyl)-2H-pyridazin-3-one "A199" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-[4-(5-meth- yl-1,2,4-oxadiazol-3-yl)phenyl]-2H-pyridazin-3-one "A200" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-pyridin-4-- yl-2H-pyridazin-3-one "A201" 6-(3-bromophenyl)-2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]be- nzyl}-2H-pyridazin-3-one "A202" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(3,4,5-tri- fluorophenyl)-2H-pyridazin-3-one "A203" 6-(3,5-dimethoxyphenyl)-2-{3-[5-(3-dimethylaminopropoxy)-pyrimidin-- 2-yl]benzyl}-2H-pyridazin-3-one "A204" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(3-fluoro-- 4-methoxyphenyl)-2H-pyridazin-3-one "A205" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(4-methoxy- phenyl)-2H-pyridazin-3-one "A206" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(3-trifluo- romethylphenyl)-2H-pyridazin-3-one, "A207" 6-(3-chlorophenyl)-2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]b- enzyl}-2H-pyridazin-3-one "A208" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-pyridin-3-- yl-2H-pyridazin-3-one "A209" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-- 1H-pyrazol-4-yl)-2H-pyridazin-3-one "A210" 6-(3-chloro-5-fluorophenyl)-2-{3-[5-(3-dimethylaminopropoxy)-pyrimi- din-2-yl]benzyl}-2H-pyridazin-3-one "A211" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(4-fluoro-- 3-methoxyphenyl)-2H-pyridazin-3-one "A212" 6-(4-chlorophenyl)-2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]b- enzyl}-2H-pyridazin-3-one "A213" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(4-fluorop- henyl)-2H-pyridazin-3-one "A214" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-thiophen-2- -yl-2H-pyridazin-3-one "A215" ##STR00446## "A216" 6-(3,4-dimethoxyphenyl)-2-{3-[5-(3-dimethylaminopropoxy)-pyrimidin-- 2-yl]benzyl}-2H-pyridazin-3-one "A217" ##STR00447## "A218" 2-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-furan-3-yl- -2H-pyridazin-3-one "A219" 2-{3-[5-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-(5-methyl-1,2- ,4-oxadiazol-3-yl)-2H-pyridazin-3-one "A220" 4-(1-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6-oxo-- 1,6-dihydropyridazin-3-yl)benzonitrile "A221" 3-(1-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6-oxo-- 1,6-dihydropyridazin-3-yl)benzonitrile "A222" 3-(1-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6- -dihydropyridazin-3-yl)benzonitrile "A223" 2-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6-pyridin- -4-yl-2H-pyridazin-3-one "A224" 6-(4-methanesulfonylphenyl)-2-{3-[5-(1-methylpiperidin-4-yloxy)-pyr- imidin-2-yl]benzyl}-2H-pyridazin-3-one "A225" ##STR00448## "A226" 2-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6-(1-meth- yl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A227" ##STR00449## "A228" ##STR00450## "A229" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-ylethoxy)-pyrim- idin-2-yl]benzyl}-2H-pyridazin-3-one "A230" 2-[3-(5-bromopyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4-yl)-2H- -pyridazin-3-one "A231" 2-[3-(5-hydroxypyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4-yl)-- 2H-pyridazin-3-one "A235" 6-(3-fluorophenyl)-2-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]b- enzyl}-2H-pyridazin-3-one "A237" 2-{3-[5-(1-methylpiperidin-4-ylmethoxy)pyrimidin-2-yl]benzyl}-6-(1-- methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A238" 2-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6-(1-meth- yl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A239" 2-[3-(5-methoxypyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4-yl)-- 2H-pyridazin-3-one "A240" 2-{3-[5-(3-methoxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyr- azol-4-yl)-2H-pyridazin-3-one "A241" 2-{3-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyra- zol-4-yl)-2H-pyridazin-3-one "A242" 2-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-6-(1-propyl-- 1H-pyrazol-4-yl)-2H-pyridazin-3-one "A243" 2-(3-{5-[2-(4-methylpiperazin-1-yl)ethoxy]pyrimidin-2-yl}-benzyl)-6- -(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A244" ##STR00451## "A245" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(3-morpholin-4-ylpropoxy)-pyri- midin-2-yl]benzyl}-2H-pyridazin-3-one "A246" ##STR00452## "A247" ##STR00453## "A248" 2-{3-[5-(2-dimethylaminoethoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1- H-pyrazol-4-yl)-2H-pyridazin-3-one "A249" ##STR00454## "A250" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-pyrrolidin-1-ylethoxy)-pyri- midin-2-yl]benzyl}-2H-pyridazin-3-one "A251" 2-[3-(5-ethoxypyrimidin-2-yl)benzyl]6-(1-methyl-1H-pyrazol-4-yl)-2H- -pyridazin-3-one "A252" ##STR00455## "A253" 6-(3-chlorophenyl)-2-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]b- enzyl}-2H-pyridazin-3-one "A254" ##STR00456## "A255" ##STR00457## "A256" ##STR00458## "A257" 3-(1-{3-[5-(1-methylpiperidin-4-ylmethoxy)pyrimidin-2-yl]-benzyl}-6- -oxo-1,6-dihydropyridazin-3-yl)benzonitrile "A260" 3-(1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6- -dihydropyridazin-3-yl)benzamide "A261" ##STR00459## "A262" 3-{1-[3-(5-bromopyrimidin-2-yl)benzyl]-6-oxo-1,6-dihydro-pyridazin-- 3-yl}benzonitrile "A263" 3-{1-[3-(5-hydroxypyrimidin-2-yl)benzyl]6-oxo-1,6-dihydro-pyridazin- -3-yl}benzonitrile "A264" 3-(6-oxo-1-{3-[5-(piperidin-4-ylmethoxy)pyrimidin-2-yl]benzyl}-1,6-- dihydropyridazin-3-yl}benzontrile "A265" tert-butyl 4-(2-{3-[3-(3-cyanophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin- -5-yloxymethyl)piperidine-1- carboxylate "A266" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(piperidin-4-yloxy)-pyrimidin-- 2-yl]benzyl}-2H-pyridazin-3-one "A267" 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(piperidin-4-ylmethoxy)-pyrimi- din-2-yl]benzyl}-2H-pyridazin-3-one "A268" ##STR00460## "A269" ##STR00461## "A270" 3-[1-(3-{5-[2-(4-methylpiperazin-1-yl)ethoxy]pyrimidin-2-yl}-benzyl- )-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile "A271" 3-(1-{3-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydr- opyridazin-3-yl)benzonitrile "A272" 3-(1-{3-[5-(3-methoxypropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihyd- ropyridazin-3-yl)benzonitrile "A273" 6-(3-fluorophenyl)-2-{3-[5-(1-methylpiperidin-4-ylmethoxy)-pyrimidi- n-2-yl]benzyl}-2H-pyridazin-3-one "A274" 2-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6-(1-prop- yl-1H-pyrazol-4-yl)-2H-pyridazin-3-one "A275" 6-(3-chlorophenyl)-2-{3-[5-(1-methylpiperidin-4-ylmethoxy)-pyrimidi- n-2-yl]benzyl}-2H-pyridazin-3-one "A276" ##STR00462## "A276a" ##STR00463## "A277" 5-(1-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6-oxo-- 1,6-dihydropyridazin-3-yl)thiophene-2-carboxylic acid "A278" 5-(1-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]benzyl}-6-oxo-- 1,6-dihydropyridin-3-yl)thiophene-2-carboxamide "A279" N-methyl-5-(1-{3-[5-(1-methylpiperidin-4-yloxy)pyrimidin-2-yl]-benz- yl}-6-oxo-1,6-dihydropyridazin-3-yl)thiophene-2- carboxamide "A283" methyl (E)-3-(2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin-1-ylmethyl]phen- yl}pyrimidin-5-yl)acrylate "A284" 2-{3-[5-((E)-3-aminopropenyl)pyrimidin-2-yl]benzyl}-6-(3,4,5-triflu- orophenyl)-2H-pyridazin-3-one "A285" 2-{3-[5-(3-aminopropyl)pyrimidin-2-yl]benzyl}-6-(3,4,5-trifluorophe- nyl)-2H-pyridazin-3-one "A286" 2-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-6-(1-methyl-- 1H-pyrazol-4-yl)-2H-pyridazin-3-one "A287" 3-(1-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-6-oxo-1,6- -dihydropyridazin-3-yl)benzonitrile "A288" 3-{6-oxo-1-[3-(5-piperazin-1-ylpyrimidin-2-yl)benzyl]-1,6-dihydropy- ridazin-3-yl}benzonitrile "A289" 6-(3-methanesulfonylphenyl)-2-[3-(5-piperazin-1-ylpyrimidin-2-yl)be- nzyl]-2H-pyridazin-3-one "A290" 4-{1-[3-(5-aminopyrimidin-2-yl)benzyl]-6-oxo-1,6-dihydropyridazin-3- -yl}benzonitrile "A291" 3-{1-[3-(5-aminopyrimidin-2-yl)benzyl]-6-oxo-1,6-dihydropyridazin-3- -yl}benzonitrile "A292" 6-(1-methyl-1H-pyrazol-4-yl)-2-[3-(5-piperazin-1-ylpyrimidin-2-yl)b- enzyl]-2H-pyridazin-3-one "A293" 2-[3-(5-aminopyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4-yl)-2H- -pyridazin-3-one "A294" 2-{3-[5-(2-hydroxyethoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyra- zol-4-yl)-2H-pyridazin-3-one "A295" 3-(1-{3-[5-(3-hydroxypropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihyd- ropyridazin-3-yl)benzonitrile "A296" 3-(1-{3-[5-(2-hydroxyethoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydr- opyridazin-3-yl)benzonitrile "A297" 2-{3-[5-(3-hydroxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyr- azol-4-yl)-2H-pyridazin-3-one "A298" 3-[1-(1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]phenyl}-ethyl)- -6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile "A299" 6-(3,5-difluorophenyl)-2-(1-{3-[5-(3-dimethylaminopropoxy)-pyrimidi- n-2-yl]phenyl}ethyl)-2H-pyridazin-3-one "A300" 6-(3,5-difluorophenyl)-2-((R)-1-{3-[5-(3-dimethylaminopropoxy)-pyri- midin-2-yl]phenyl}ethyl)-2H-pyridazin-3-one "A301" 6-(3,5-difluorophenyl)-2-((S)-1-{3-[5-(3-dimethylaminopropoxy)-pyri- midin-2-yl]phenyl}ethyl)-2H-pyridazin-3-one "A302" 3-(1-{3-[5-(1-methyl-1-oxypiperidin-4-ylmethoxy)pyrimidin-2-yl]-ben- zyl}-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile "A303" 3-(1-{3-[5-(1-formylpiperidin-4-ylmethoxy)pyrimidin-2-yl]-benzyl}-6- -oxo-1,6-dihydropyridazin-3-yl)benzonitrile "A304" ##STR00464## "A305" ##STR00465## "A306" ##STR00466## "A307" ##STR00467## "A308" ##STR00468## "A309" ##STR00469## "A310" ##STR00470## "A311" ##STR00471## "A312" ##STR00472## "A313" ##STR00473## "A314" ##STR00474## or a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof. 16. A method according to claim 14, wherein 3-(1-{3-[5-(1-methylpiperidin-4-ylmethoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,- 6-dihydropyridazin-3-yl)benzonitrile or a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof is administered. 17. A method according to claim 1, wherein a compound of formula I or a pharmaceutically acceptable salt thereof is administered. 18. A method according to claim 16, wherein a compound of formula I or a pharmaceutically acceptable salt thereof is administered. 19. A method according to claim 1, which is for the treatment of a disease which is influenced by inhibition of a tyrosine kinase. 20. A method according to claim 1, which is for the treatment of a disease which influenced by inhibition of Met kinase. 21. A method according to claim 1, which is for treating a disease in which the inhibition, regulation and/or modulation of kinase signal transduction plays a role, where the disease treated is a tumour of the blood or immune system. 22. A method according to claim 1, which is for treating a disease in which the inhibition, regulation and/or modulation of kinase signal transduction plays a role, where the disease treated is a solid tumour. 23. A method according to claim 22, where the solid tumour originates from a tumour of the squamous epithelium, the bladder, the stomach, the kidneys, of head and neck, the oesophagus, the cervix, the thyroid, the intestine, the liver, the brain, the prostate, the urogenital tract, the lymphatic system, the stomach, the larynx or the lung. 24. A method according to claim 22, where the solid tumour originates from monocytic leukaemia, lung adenocarcinoma, small-cell lung carcinomas, pancreatic cancer, glioblastomas or breast carcinoma. 25. A method according to claim 22, where the solid tumour originates from lung adenocarcinoma, small-cell lung carcinomas, pancreatic cancer, glioblastomas, colon carcinoma or breast carcinoma. 26. A method according to claim 22, where the tumour originates from acute myeloid leukaemia, chronic myeloid leukaemia, acute lymphatic leukaemia or chronic lymphatic leukaemia. 27. A method according to claim 1, which is for inhibiting Met kinase and/or tyrosine kinase. 28. A method according to claim 14, which is for inhibiting Met kinase and/or tyrosine kinase.