Claims for Patent: 8,956,658
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Summary for Patent: 8,956,658
| Title: | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
| Abstract: | The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications. |
| Inventor(s): | Schoenfisch Mark H., Shin Jae Ho, Stasko Nathan |
| Assignee: | The University of North Carolina at Chapel Hill |
| Application Number: | US14014939 |
| Patent Claims: | 1. A nitric oxide-releasing particle comprising:a co-condensed silica network comprising methylaminopropyl trimethoxysilane (MAP3) and tetraethyl orthosilicate (TEOS), wherein the MAP3 is distributed throughout the nitric oxide-releasing particle, and wherein the MAP3 comprises N-diazeniumdiolate functionalized MAP3.2. The nitric oxide-releasing particle of claim 1 , wherein the MAP3 is present in a mol % of 10% to 75%.3. The nitric oxide-releasing particle of claim 1 , wherein the MAP3 is present in a mol % of 1% to 90%.4. The nitric oxide-releasing particle of claim 1 , wherein the MAP3 is present in a mol % of 45% to 55%.5. The nitric oxide-releasing particle of claim 4 , wherein the MAP3 is present in a mol % of about 50%. |
