Claims for Patent: 8,957,046

Summary for Patent: 8,957,046

Title:	Nucleoside phosphoramidate prodrugs
Abstract:	Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: ##STR00001## Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
Inventor(s):	Du; Jinfa (Redwood City, CA), Nagarathnam; Dhanapalan (Bethany, CT), Sofia; Michael Joseph (Doylestown, PA), Wang; Peiyuan (Foster City, CA)
Assignee:	Gilead Pharmasset LLC (Foster City, CA)
Application Number:	14/254,737
Patent Claims:	1. A method of treating a human infected by hepatitis C virus, comprising administering to the subject an effective amount of an NS3 inhibitor and an effective amount of a compound represented by the following formula: ##STR00092## 2. The method of claim 1, wherein the NS3 inhibitor is a compound represented by the following formula: ##STR00093##