Claims for Patent: 8,987,463
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Summary for Patent: 8,987,463
| Title: | Methods of synthesizing factor Xa inhibitors |
| Abstract: | Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof. ##STR00001## |
| Inventor(s): | Pandey; Anjali (Fremont, CA), Leitao; Emilia P. T. (Lisbon, PT), Rato; Jose (Lisbon, PT), Song; Zhiguo Jake (Edison, NJ) |
| Assignee: | Millennium Pharmaceuticals, Inc. (Cambridge, MA) Portola Pharmaceuticals, Inc. (South San Francisco, CA) |
| Application Number: | 13/757,483 |
| Patent Claims: |
1. A composition comprising at least 99.7% betrixaban free base or at least 99.7% betrixaban maleate salt.
2. The composition of claim 1, comprising at least 99.8% betrixaban maleate salt. 3. The composition of claim 2, comprising at least 99.9% betrixaban maleate salt. 4. A composition comprising betrixaban free base or salt thereof that comprises less than 0.15% of Compound L and/or Compound M: ##STR00053## 5. The composition of claim 4 wherein the salt is the maleate salt. |
