Claims for Patent: 8,999,313

Summary for Patent: 8,999,313

Title:	Compositions
Abstract:	The invention provides a colon cleansing solution comprising: a) 300 to 800 mmol per liter ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and b) 10 to 200 g per liter polyethylene glycol. The invention also provides methods an kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.
Inventor(s):	Clayton; Lucy (Uxbridge, GB), Cockett; Alasdair (Uxbridge, GB), Christodoulou; Mark (Uxbridge, GB), Davidson; Ian (Uxbridge, GB), Farrag; Lynn (Uxbridge, GB), Halphen; Marc (London, GB), Jones; Leighton (Uxbridge, GB), Petrossian; Vanik (Woburn, MA), Stein; Peter (Amsterdam Zuid-Oost, NL), Tisi; David (Woburn, MA), Ungar; Alex (Wigton, GB), Worthington; Jeffrey (Woburn, MA)
Assignee:	Norgine BV (Amsterdam Zuid-Oost, NL)
Application Number:	14/223,127
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,999,313
Patent Claims:	1. A composition for admixture with water which comprises: a) 150 to 400 mmol ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and b) 5 to 100 g polyethylene glycol having an average molecular weight of 3000 to 4000 Da. 2. A composition as claimed in claim 1 wherein the ascorbate anion is provided by 3.3 to 12.8 g ascorbic acid and 24.3 to 69 g sodium ascorbate. 3. A composition as claimed in claim 1 wherein the ascorbate anion is provided by 6.0 to 10 g ascorbic acid and 40 to 60 g sodium ascorbate. 4. A composition as claimed in claim 1 wherein the ascorbate anion is provided by 7.0 to 8.0 g ascorbic acid and 47 to 56 g sodium ascorbate. 5. A composition as claimed in claim 1 wherein the ascorbate anion is provided by 5.0 to 10 g ascorbic acid and 45 to 65 g potassium ascorbate. 6. A composition as claimed in claim 1 wherein the ascorbate anion is provided by 5.0 to 10 g ascorbic acid and 38 to 57 g magnesium ascorbate. 7. A composition as claimed in claim 1 wherein the molar ratio of the components (i) and (ii) is from 1:5.40 to 1:5.80. 8. A composition as claimed in claim 1 further comprising 1.5 to 4 g sodium chloride. 9. A composition as claimed in claim 1 further comprising 0.75 to 2.5 g potassium chloride. 10. A composition as claimed in claim 1 which is essentially free from alkali metal sulphates or alkaline earth metal sulphates. 11. A composition as claimed in claim 1 comprising one or more flavouring agents and one or more sweeteners. 12. A composition as claimed in claim 11 comprising 0.025 to 1.0 g of flavouring. 13. A composition as claimed in claim 11 comprising 0.25 to 2 g of sweetener. 14. A composition as claimed in claim 1 wherein the components are in dry powder, granular or other dry form. 15. A composition as claimed in claim 1 wherein the components are in the form of concentrates or slurries. 16. A composition as claimed in claim 1 which composition is for the preparation of a 500 ml or 16 US fluid ounces dose of colon cleansing solution. 17. A composition as claimed in claim 1 wherein the ascorbate component (a) and the PEG component (b) are packaged separately from each other. 18. A composition as claimed in claim 1 comprising: a) an ascorbate component comprising (i) 6.0 to 10 g ascorbic acid and (ii) 40 to 60 g sodium ascorbate the components (i) and (ii) being present in a weight ratio of from 1:5063 to 1:7.875; b) 30 to 50 g PEG having an average molecular weight of 3000 to 4000 Da; c) 1.5 to 4 g sodium chloride and 0.5 to 3.5 g potassium chloride; e) one or more flavouring agents; and f) one or more sweeteners. 19. A composition as claimed in claim 18 which composition is for the preparation of a 500 ml dose of colon cleansing solution. 20. A composition as claimed in claim 18 wherein the ascorbate component (a) and the PEG component (b) are packaged separately from each other. 21. A composition as claimed in claim 18 which is essentially free from alkali metal sulphates or alkaline earth metal sulphates. 22. A composition as claimed in claim 18 which comprises 0.1 to 0.9 g of flavouring, selected from lemon, kiwi, strawberry, grapefruit, orange, fruit punch and mango flavour. 23. A composition as claimed in claim 18 which comprises 0.25 to 2 g of sweetener, selected from aspartame and acesulfame potassium. 24. A composition comprising: a) an ascorbate component comprising (i) 7.43 g ascorbic acid and (ii) 48.11 g sodium ascorbate b) 40 g PEG having an average molecular weight of 3000 to 4000 Da; c) 3.20 g sodium chloride and 1.20 g potassium chloride; e) one or more flavouring agents; and f) one or more sweeteners. 25. A composition as claimed in claim 24 which composition is for the preparation of a 500 ml dose of colon cleansing solution. 26. A composition as claimed in claim 24 wherein the ascorbate component (a) and the PEG component (b) are packaged separately from each other. 27. A composition as claimed in claim 24 which is essentially free from alkali metal sulphates or alkaline earth metal sulphates. 28. A composition as claimed in claim 24 which comprises 0.1 to 0.9 g of flavouring, selected from lemon, kiwi, strawberry, grapefruit, orange, fruit punch and mango flavour. 29. A composition as claimed in claim 18 which comprises 0.25 to 2 g of sweetener, selected from aspartame and acesulfame potassium. 30. A kit comprising: A) a first component, being a composition for the preparation of a first colon cleansing solution by admixture with water; and B) a second component, being a composition for the preparation of a second colon cleansing solution by admixture with water, wherein the second component comprises: a) an ascorbate component comprising (i) 7.43 g ascorbic acid and (ii) 48.11 g sodium ascorbate b) 40 g PEG having an average molecular weight of 3000 to 4000 Da; c) 3.20 g sodium chloride and 1.20 g potassium chloride; e) one or more flavouring agents; and f) one or more sweeteners.