Claims for Patent: 8,999,996

Summary for Patent: 8,999,996

Title:	Hydrazide containing nuclear transport modulators and uses thereof
Abstract:	The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.
Inventor(s):	Sandanayaka; Vincent P. (Northboro, MA), Shacham; Sharon (Newton, MA), McCauley; Dilara (Cambridge, MA), Shechter; Sharon (Andover, MA)
Assignee:	Karyopharm Therapeutics Inc. (Newton, MA)
Application Number:	14/219,638
Patent Claims:	1. A compound represented by the following structural formula: ##STR00174## or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition comprising a compound represented by the following structural formula: ##STR00175## or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.