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Last Updated: November 25, 2024

Claims for Patent: 9,090,558

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Summary for Patent: 9,090,558

Title:	Prodrugs of fumarates and their use in treating various diseases
Abstract:	The present invention provides compounds of formula (I), ##STR00001## wherein: R.sub.1 is unsubstituted C.sub.1-C.sub.6 alkyl; L.sub.a is substituted or unsubstituted C.sub.1-C.sub.6 alkyl linker, substituted or unsubstituted C.sub.3-C.sub.10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; and R.sub.2 and R.sub.3 are each, independently, H, substituted or unsubstituted C.sub.1-C.sub.6 alkyl, or substituted or unsubstituted C.sub.6-C.sub.10 aryl; or alternatively, R.sub.2 and R.sub.3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S. The invention also provides pharmaceutical compositions and methods for treating neurological diseases, such as multiple sclerosis.
Inventor(s):	Zeidan; Tarek A. (Watertown, MA), Duncan; Scott (Bedford, MA), Hencken; Christopher P. (Boston, MA), Wynn; Thomas Andrew (Lexington, MA), Sanrame; Carlos N. (Lexington, MA)
Assignee:	Alkermes Pharma Ireland Limited (Dublin, IE)
Application Number:	14/180,687
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 9,090,558
Patent Claims:	1. A method of treating multiple sclerosis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound having the formula: ##STR00059## or a pharmaceutically acceptable salt thereof. 2. A method of treating multiple sclerosis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound having the formula: ##STR00060##

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