You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: December 23, 2024

Claims for Patent: 9,108,975

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 9,108,975

Title:	Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
Abstract:	Stable crystalline forms of a compound represented by the formula (IA): ##STR00001## an acid addition salt, and/or a solvate thereof are provided by the present invention. Said crystalline forms are extremely useful as materials for preparing medicines. Novel processes for preparing 6,7-unsaturated-7-carbamoyl morphinan derivatives are also provided by the present invention.
Inventor(s):	Tamura; Yoshinori (Toyonaka, JP), Noguchi; Kouichi (Amagasaki, JP), Inagaki; Masanao (Toyonaka, JP), Morimoto; Kenji (Toyonaka, JP), Haga; Nobuhiro (Toyonaka, JP), Oda; Shinichi (Iwate-ken, JP), Omura; Sohei (Amagasaki, JP)
Assignee:	Shionogi & Co., LTD. (Osaka, JP)
Application Number:	13/884,770
Patent Claims:	1. A p-toluenesulfonic acid salt of a compound of the formula (IA): ##STR00050## 2. A crystal of a p-toluenesulfonic acid salt of a compound of the formula (IA): ##STR00051## 3. The crystal of the p-toluenesulfonic acid salt according to claim 2, wherein the X-ray powder diffraction spectrum of the crystal has peaks at diffraction angles (2.theta.) of: 7.8.degree..+-.0.2.degree., 10.6.degree.,.+-.0.2.degree., 15.6.degree..+-.0.2, 17.8.degree..+-.0.2.degree. and 21.5.degree..+-.0.2.degree.. 4. The crystal of the p-toluenesulfonic acid salt according to claim 2, wherein the X-ray powder diffraction spectrum of the crystal has peaks at diffraction angles (2.theta.) of: 7.8.degree..+-.0.2.degree., 10.6.degree..+-.0.2.degree., 15.6.degree..+-.0.2.degree., 18.6.degree.,.+-.0.2.degree., 20.4.degree..+-.0,2.degree., 21.9.degree..+-.0.2.degree., 23.6.degree..+-.0.2.degree. and 25.5.degree..+-.0.2.degree.. 5. The crystal of the p-toluenesuifonic acid salt according to claim 2, wherein the X-ray powder diffraction spectrum of the crystal is substantially identical to FIG. 1. 6. The crystal of the p-toluenesuifonic acid salt according to claim 2, wherein the X-ray powder diffraction spectrum of the crystal has peaks at diffraction angles (2.theta.) of: 12.9.degree..+-.0.2.degree., 17.6.degree..+-.0.2.degree., 22.4.degree.,02.degree., 25.4.degree..+-.0,2.degree. and 28.7.degree..+-.0.2.degree.. 7. The crystal of the p-toluenesulfonic acid salt according to claim 2, wherein the X-ray powder diffraction spectrum of the crystal has peaks at diffraction angles (2.theta.) of: 6.6.degree..+-.0.2.degree., 8.9.degree..+-.0.2.degree.11.4.degree..+-.0.2.degree., 12.9.degree..+-.0.2.degree., 14.0.degree..+-.0.2.degree., 15.0.degree..+-.0.2.degree., 17.6.degree..+-.0.2.degree., 18.2.degree..+-.0.2.degree.22.4.degree..+-.0.2.degree.25.4.degree..+-.0.2- .degree. and 28.7.degree...+-.0.2.degree.. 8. The crystal of the p-toluenesulfonic acid salt according to claim 2, wherein the X-ray powder diffraction spectrum of the crystal is substantially identical to FIG. 2. 9. The crystal of the p-toluenesulfonic acid salt according to claim 2, wherein the X-ray powder diffraction spectrum of the crystal has peaks at diffraction angles (2.theta.) of: 8.8.degree..+-.0.2.degree., 17.5.degree..+-.0.2.degree., 21.9.degree..+-.0.2.degree., 23.7.degree..+-.0.2.degree. and 26.1.degree..+-.0.2.degree.. 10. The crystal of the p-toluenesulfonic acid salt according to claim 2, wherein the X-ray powder diffraction spectrum of the crystal has peaks at diffraction angles (2.theta.) of: 7.1.degree..+-.0.2.degree., 8.8.degree..+-.0.2.degree., 17.5.degree..+-.0.2.degree., 19.2.degree..+-.0.2.degree., 19.7.degree..+-.0.2.degree., 21.2.degree..+-.0.2.degree., 21.9.degree..+-.0.2.degree.23.7.degree..+-.0.2.degree., 24.5.degree..+-.0.2.degree. and 26.1.degree..+-.0.2.degree.. 11. The crystal of the p-toluenesulfonic acid salt according to claim 2, wherein the X-ray powder diffraction spectrum of the crystal is substantially identical to FIG. 3. 12. A pharmaceutical composition comprising the crystal according to claim 2. 13. The crystal of the p-toluenesulfonic acid salt according to claim 2, wherein the salt is a non-solvate. 14. The crystal of the p-toluenesulfonic acid salt according to claim 2, wherein the salt is a hydrate. 15. The crystal of the p-toluenesulfonic acid salt according to claim 14, wherein the crystal is Form I hydrate. 16. The crystal of the p-toluenesulfonic acid salt according to claim 14, wherein the crystal is Form II hydrate. 17. The p-toluenesulfonic acid salt of claim 1, wherein the salt is a hydrate, 18. The p-toluenesulfonic acid salt of claim 1, wherein the salt is a non-solvate,

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.