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Last Updated: November 24, 2024

Claims for Patent: 9,169,250


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Summary for Patent: 9,169,250
Title:Compounds modulating c-fms and/or c-kit activity and uses therefor
Abstract: Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
Inventor(s): Zhang; Jiazhong (Burlingame, CA), Ibrahim; Prabha N. (Mountain View, CA), Bremer; Ryan (Emeryville, CA)
Assignee: Plexxikon Inc. (Berkeley, CA)
Application Number:14/250,331
Patent Claims: 1. A pharmaceutical composition comprising a compound of formula: ##STR00923## and a pharmaceutically acceptable carrier, diluent or excipient.

2. The pharmaceutical composition of claim 1 in unit dosage form.

3. The pharmaceutical composition of claim 2, wherein the unit dosage form is a capsule or a tablet.

4. The pharmaceutical composition of claim 2, wherein the unit dosage form is a capsule.

5. The pharmaceutical composition of claim 2, wherein the unit dosage form is a tablet.

6. A hydrochloric acid salt of a compound of formula: ##STR00924##

7. A pharmaceutical composition comprising the hydrochloric acid salt of claim 6, and a pharmaceutically acceptable carrier, diluent or excipient.

8. The pharmaceutical composition of claim 7 in unit dosage form.

9. The pharmaceutical composition of claim 8, wherein the unit dosage form is a capsule or a tablet.

10. The pharmaceutical composition of claim 8, wherein the unit dosage form is a capsule.

11. The pharmaceutical composition of claim 8, wherein the unit dosage form is a tablet.

12. A polymorphic form of a compound of formula: ##STR00925##

13. A pharmaceutical composition comprising the polymorphic form of claim 12, and a pharmaceutically acceptable carrier, diluent or excipient.

14. The pharmaceutical composition of claim 13 in unit dosage form.

15. The pharmaceutical composition of claim 14, wherein the unit dosage form is a capsule or a tablet.

16. The pharmaceutical composition of claim 14, wherein the unit dosage form is a capsule.

17. The pharmaceutical composition of claim 14, wherein the unit dosage form is a tablet.

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