Claims for Patent: 9,233,097
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Summary for Patent: 9,233,097
| Title: | ST-246 liquid formulations |
| Abstract: | The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation. |
| Inventor(s): | Tyavanagimatt; Shanthakumar R. (Corvallis, OR), Stone; Melialani A. C. L. (Corvallis, OR), Weimers; William C. (Corvallis, OR), Kasi; Gopi Krishna (Corvallis, OR), Samuel; Peter N. K. (Corvallis, OR), Bolken; Tove (Keizer, OR), Hruby; Dennis E. (Albany, OR) |
| Assignee: | SIGA TECHNOLOGIES, INC. (Corvallis, OR) |
| Application Number: | 13/814,102 |
| Patent Claims: |
1. A liquid pharmaceutical formulation comprising a therapeutically effective amount of ST-246 and hydroxypropyl-.beta.-cyclodextrin and/or
sufobutyl-ether-.beta.-cylodextrin, and further comprising one or more pharmaceutically acceptable ingredients.
2. The liquid pharmaceutical formulation of claim 1, wherein said pharmaceutically acceptable ingredients are selected from the group consisting of carrier, excipient, diluent, additive, filler, lubricant and binder. 3. The liquid pharmaceutical formulation of claim 1, wherein said hydroxypropyl-.beta.-cyclodextrin is present in amounts from about 20% to about 40% by weight. 4. The liquid pharmaceutical formulation of claim 1 having a pH between about 3 and 10. 5. The liquid pharmaceutical formulation of claim 1, wherein said hydroxypropyl-.beta.-cyclodextrin has a degree of substitution of between about 4.0 to about 8.0. |
