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Last Updated: November 7, 2024

Claims for Patent: 9,241,915

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Summary for Patent: 9,241,915

Title:	Method for enhancing the bioavailability of ospemifene
Abstract:	This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) ##STR00001## or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
Inventor(s):	Anttila; Markku (Turku, FI)
Assignee:	QuatRx Pharmaceuticals (Ann Arbor, MI)
Application Number:	14/310,822
Patent Claims:	1. A method for enhancing the bioavailability of a therapeutically active compound of the formula (I) ##STR00005## or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to an individual in connection with the intake of food. 2. The method according to claim 1 wherein compound (I) is ospemifene. 3. The method according to claim 1 wherein the compound is administered at a time point which is in the range defined by 1 hour before starting the food intake and 2 hours after starting the food intake. 4. The method according to claim 3 wherein the compound is administered at a time point which is in the range defined to begin at a time point during the food intake and to end 1 hour after the food intake was started. 5. The method according to claim 4 wherein the compound is administered at a time point which is no later than 0.5 hour after starting the food intake. 6. The method according to claim 1 wherein the food is any foodstuff of nutritional value being capable of causing secretion of bile acids. 7. The method according to claim 1 wherein the compound is used for treatment of osteoporosis. 8. The method according to claim 1 wherein the compound is used for treatment of symptoms related to skin atrophy, or to epithelial or mucosal atrophy. 9. The method according to claim 8 wherein the symptoms are urinary symptoms or vaginal symptoms.

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