Claims for Patent: 9,241,946

Summary for Patent: 9,241,946

Title:	Methods of treating acne
Abstract:	A method of treating acne in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is effective to treat acne but has substantially no antibiotic activity, without administering a bisphosphonate compound.
Inventor(s):	Ashley; Robert A. (Newtown, PA)
Assignee:	GALDERMA LABORATORIES INC. (Fort Worth, TX)
Application Number:	14/753,544
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 9,241,946
Patent Claims:	1. A method for treating acne in a human in need thereof, the method comprising administering orally to said human doxycycline, or a pharmaceutically acceptable salt thereof, in an amount that (i) is effective to treat acne; (ii) is 10-80% of a 50 mg dose of doxycycline per day; and (iii) results in no reduction of skin microflora during a six-month treatment, without administering a bisphosphonate compound, wherein said doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount which provides a serum concentration in the range of about 0.1 to about 0.8 .mu.g/ml. 2. The method according to claim 1, wherein said doxycycline is doxycycline monohydrate. 3. The method according to claim 2, wherein said doxycycline monohydrate is administered in an amount of 40 milligrams per day. 4. The method according to claim 3, wherein said doxycycline monohydrate is administered by sustained release. 5. A method according to claim 4, wherein said doxycycline monohydrate is administered once a day. 6. The method according to claim 2, wherein said doxycycline monohydrate is administered in a dose of 20 mg twice a day. 7. A method for treating acne in a human in need thereof, the method comprising administering orally to said human doxycycline, or a pharmaceutically acceptable salt thereof, in an amount that (i) is effective to treat acne; (ii) is 40-80% of a 50 mg dose of doxycycline per day; and (iii) results in no reduction of skin microflora during a six-month treatment, without administering a bisphosphonate compound, wherein said doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount which provides a serum concentration in the range of about 0.1 to about 0.8 .mu.g/ml. 8. The method according to claim 7, wherein said doxycycline is doxycycline monohydrate. 9. The method according to claim 8, wherein said doxycycline monohydrate is administered in an amount of 40 milligrams per day. 10. The method according to claim 9, wherein said doxycycline monohydrate is administered by sustained release. 11. A method according to claim 10, wherein said doxycycline monohydrate is administered once a day. 12. The method according to claim 8, wherein said doxycycline monohydrate is administered in a dose of 20 mg twice a day. 13. A method for treating acne in a human in need thereof, the method comprising administering orally to said human doxycycline, or a pharmaceutically acceptable salt thereof, in an amount of 40 mg per day, wherein the amount results in no reduction of skin microflora during a six-month treatment, without administering a bisphosphonate compound, wherein said doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount which provides a serum concentration in the range of about 0.1 to about 0.8 .mu.g/ml. 14. The method according to claim 13, wherein said doxycycline is doxycycline monohydrate. 15. The method according to claim 14, wherein said doxycycline monohydrate is administered by sustained release. 16. A method according to claim 15, wherein said doxycycline monohydrate is administered once a day. 17. The method according to claim 14, wherein said doxycycline monohydrate is administered in a dose of 20 mg twice a day. 18. The method according to claim 1, wherein said doxycycline is doxycycline hyclate. 19. The method according to claim 18, wherein said doxycycline hyclate is administered in an amount of 40 milligrams per day. 20. The method according to claim 19, wherein said doxycycline hyclate is administered by sustained release. 21. A method according to claim 20, wherein the acne is acne rosacea. 22. The method according to claim 18, wherein said doxycycline hyclate is administered in a dose of 20 mg twice a day. 23. The method according to claim 7, wherein said doxycycline is doxycycline hyclate. 24. The method according to claim 23, wherein said doxycycline hyclate is administered in an amount of 40 milligrams per day. 25. The method according to claim 24, wherein said doxycycline hyclate is administered by sustained release. 26. A method according to claim 25, wherein said acne is acne rosacea. 27. The method according to claim 23, wherein said doxycycline hyclate is administered in a dose of 20 mg twice a day. 28. The method according to claim 13, wherein said doxycycline is doxycycline hyclate. 29. The method according to claim 28, wherein said acne is acne rosacea. 30. The method according to claim 28, wherein said doxycycline hyclate is administered by sustained release. 31. A method according to claim 28, wherein said acne is acne rosacea. 32. The method according to claim 28, wherein said doxycycline hyclate is administered in a dose of 20 mg twice a day.