Claims for Patent: 9,248,148

Summary for Patent: 9,248,148

Title:	Mono (iron hydroxypyrone) and combination (iron hydroxypyrone and GI inflammation inhibiting agents) compositions for anaemia or H. pylori infections
Abstract:	There is provided a composition or kit of parts comprising: one or more compounds capable of treating and/or preventing an inflammatory disease of the gastrointestinal tract: and an iron hydroxypyrone, for increasing the level of iron in a patient's bloodstream and/or treating and/or preventing anaemia such as iron deficiency anaemia. A composition comprising iron hydroxypyrone is also provided for administration to a subject: having or at risk of having achlorhydria; wherein the gastric pH of the subject is equal to or greater than about 4; or wherein the subject has an inflammatory disease of the gastrointestinal tract.
Inventor(s):	Stockham; Michael Arthur (Essex, GB)
Assignee:	Iron Therapeutics Holdings AG (Wollerau, CH)
Application Number:	12/992,528
Patent Claims:	1. A method for increasing the level of iron in a subject's bloodstream and/or for preventing and/or treating anaemia in the subject, wherein the method consists of the steps of administering a composition comprising an iron hydroxypyrone to the subject, and maintaining the gastric pH of the subject greater that 4 during said method. 2. The method according to claim 1, wherein the composition is administered by oral administration or, wherein the method is for the absorption of iron. 3. The method according to claim 1, wherein the anaemia is iron deficiency anaemia. 4. The method according to claim 1, wherein the gastric pH is greater than 5 or 6. 5. The method according to claim 4, wherein the gastric pH is about 6.5 or above. 6. The method according to claim 1, wherein the iron hydroxypyrone comprises a ferric complex with hydroxypyrone, or a mixture of a ferrous or ferric salt and a hydroxypyrone and wherein the hydroxypyrone comprises a 3-hydroxy-4-pyrone or a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to the ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms. 7. The method according to claim 1, wherein the iron hydroxypyrone comprises ferric trimaltol or an iron (II) or iron (III) carboxylate and maltol. 8. The method according to claim 1, wherein the composition is administered to a human or animal. 9. A method for increasing the level of iron in a subject's bloodstream and/or for preventing and/or treating anaemia in the subject, wherein the method consists of the step of administering a composition comprising an iron hydroxypyrone to the subject having, or at risk of having, achlorhydria, and wherein the iron hydroxypyrone is administered in the absence of a gastrointestinal pH lowering agent. 10. The method according to claim 9, wherein the anaemia is iron deficiency anaemia. 11. The method according to claim 9, wherein the achlorhydria is associated with an inflammatory disease of the gastrointestinal tract or wherein the achlorhydria is associated with atrophic gastritis or a gastrointestinal infection, such as caused by Helicobacter pylori. 12. A method for increasing the level of iron in a subject's bloodstream and/or for preventing and/or treating anaemia in the subject, wherein the method consists of the step of administering a composition comprising an iron hydroxypyrone to a subject, and maintaining the gastric pH of the subject greater than 4 during the method, wherein the subject has an inflammatory disease of the gastrointestinal tract. 13. The method according to claim 12, wherein the anaemia is iron deficiency anaemia. 14. The method of claim 12, wherein the gastric pH of the subject is greater than 5 or 6. 15. The method according to claim 14, wherein the gastric pH is about 6.5 or above. 16. The method according to claim 6, wherein the ferrous salt is an iron (II) carboxylate. 17. The method according to claim 6, wherein the iron (II) carboxylate is selected from iron (II) gluconate, iron (II) succinate and iron (II) fumarate. 18. The method according to claim 1, claim 9 or claim 12, wherein the pH of the environment where iron is absorbed is greater than 4. 19. A method for increasing the level of iron in a subject's bloodstream and/or preventing and/or treating anaemia in the subject, wherein the method comprises the step of administering a composition comprising ferric trimaltol to the subject, wherein the gastric pH of the subject is greater than 6 and wherein iron is absorbed in the subject from the ferric trimaltol. 20. The method according to claim 1, claim 9 or claim 12, wherein the iron hydroxypyrone is administered with a pharmaceutically acceptable diluent or carrier.