Claims for Patent: 9,265,900

Summary for Patent: 9,265,900

Title:	Disposable ampoule for an aerosol generating device
Abstract:	Disposable ampoule for use in an aerosol generating device, comprising: a medicament container that contains a medicament and is formed of a container body (10) and a container bottom (11), and a predetermined break point (12) that at least partly surrounds the container bottom, characterized by a collar (15) that surrounds the predetermined break point (12) at its outside and extends the container body (10) over and beyond the container bottom (11).
Inventor(s):	Loenner; Mihaela (Poing, DE), Gallem; Thomas (Munich, DE), Hetzer; Uwe (Munich, DE)
Assignee:	PARI Pharma GmbH (Starnberg, DE)
Application Number:	12/275,512
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 9,265,900
Patent Claims:	1. A disposable ampoule for use in an aerosol generating device, comprising: a medicament container that contains a medicament and is formed of a container body and a circular container bottom, wherein the container body and the circular container bottom are integrally formed, a predetermined break line that at least partly surrounds the container bottom, that is annular, and that is located between the container bottom and the container body, the predetermined break line having a reduced material thickness compared to the container bottom, and a collar that surrounds the predetermined break line at its outside and extends the container body over and beyond the container bottom, an open end of the collar being spaced from the container bottom, the collar and the container body being disposed on opposite sides of the container bottom, the collar being integrally formed with the container body and being configured to position and guide a hollow piercing member during opening of the medicament container at the predetermined break line, the container bottom being configured to seal the medicament in the container body until pierced by the hollow piercing member, the hollow piercing member having a cutting edge, the medicament container being configured to be pierced by the cutting edge of the hollow piercing member at the predetermined break line so that the container bottom is folded to one side at the predetermined break line, being configured to supply the medicament to the aerosol generating device through the hollow piercing member and being configured to be opened at only one end, at the container bottom, wherein an inner surface of the collar is engageable with the hollow piercing member and wherein the collar is configured to create a seal between the collar and the hollow piercing member. 2. The ampoule according to claim 1, wherein starting from the container bottom, the collar expands in a conical manner at least at its inner contour. 3. The ampoule according to claim 1, wherein the container body is divided into two functional areas such that the ampoule has a modular construction. 4. The ampoule according to claim 3, wherein in the first functional area containing the container bottom, the ampoule is designed, at least at its inner contour, to extend in a conical manner in the direction of the container bottom and the second functional area is substantially configured as a hollow cylinder. 5. The ampoule according to claim 1, wherein a fixing groove is provided centrally or closer to the container bottom in the longitudinal direction of the ampoule and the ampoule is preferably divided into the two functional areas. 6. The ampoule according to claim 1, wherein at least one reinforcing rib is provided on the container body. 7. The ampoule according to claim 1, wherein a lug is provided on the container body opposite the container bottom. 8. The ampoule according to claim 1, which is produced by the blow-fill-seal process. 9. The ampoule according to claim 1, which is made of polyethylene, polypropylene or a thermoplastic copolymer. 10. The ampoule according to claim 1, wherein an additional, separate sealing element is inserted or can be inserted into the collar. 11. The ampoule according to claim 1, wherein an opening diameter of at least 8 mm is achieved owing to the dimensioning and design of the container bottom and the predetermined break line. 12. The ampoule according to claim 1, in which the medicament container contains up to 10 ml of medicament. 13. The ampoule according to claim 1, wherein the medicament contains at least one active agent. 14. The ampoule according to claim 13, wherein the medicament contains at least one auxiliary agent in dissolved or suspended form. 15. The ampoule according to claim 1, wherein the medicament is used in nebulised form for the diagnosis, prophylaxis or treatment of illnesses in humans and animals. 16. The ampoule according to claim 1, wherein the medicament can be nebulised in conjunction with a perforated oscillating membrane to form droplets having a mean mass diameter of less than 6 .mu.m. 17. The ampoule according to claim 1, wherein the medicament can be nebulised into the nose and paranasal sinuses as a pulsating aerosol having a mean mass diameter of less than 6 .mu.m. 18. The use of an ampoule according to claim 1 in an aerosol generating device, the medicament thereof being nebulised by an aerosol generator and being used for a local, nasal or pulmonary application. 19. The ampoule according to claim 11, wherein an opening diameter in a range of between 8 and 15 mm is achieved. 20. The ampoule according to claim 1, wherein the medicament container contains between 0.25 and 5 ml of medicament. 21. An aerosol generating assembly comprising: an aerosol generating device including a hollow piercing member configured to receive a medicament; and a disposable ampoule configured to provide the medicament to the aerosol generating device, the disposable ampoule including: a medicament container that contains the medicament and is formed of a container body and a container bottom, wherein the container body and the container bottom are integrally formed, a predetermined break line that at least partly surrounds the container bottom, that is annular, and that is located between the container bottom and the container body, the predetermined break line having a reduced material thickness compared to the container bottom, and a collar that surrounds the predetermined break line at its outside and extends the container body over and beyond the container bottom, an open end of the collar being spaced from the container bottom, the collar and the container body being disposed on opposite sides of the container bottom, the collar being integrally formed with the container body and being configured to position and guide the hollow piercing member during opening of the medicament container at the predetermined break line, the container bottom being configured to seal the medicament in the container body until pierced by the hollow piercing member, the hollow piercing member having a cutting edge, the medicament container being configured to be pierced by the cutting edge of the hollow piercing member at the predetermined break line so that the container bottom is folded to one side at the predetermined break line, being configured to supply the medicament to the aerosol generating device through the hollow piercing member and being configured to be opened at only one end, at the container bottom, wherein an inner surface of the collar is engageable with the hollow piercing member and wherein the collar is configured to create a seal between the collar and the hollow piercing member.