Claims for Patent: 9,351,923
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Summary for Patent: 9,351,923
Title: | Extended-release composition comprising a somatostatin derivative in microparticles |
Abstract: | The present invention relates to improved microparticles comprising a somatostatin analog, a process of making said microparticles and to pharmaceutical compositions comprising the same. |
Inventor(s): | Lambert; Olivier (Spechbach le Haut, FR), Riemenschnitter; Marc (Freiburg, DE), Vucenovic; Vitomir (Loerrach, DE) |
Assignee: | Novartis AG (Basel, CH) |
Application Number: | 13/743,385 |
Patent Claims: |
1. A pharmaceutical composition for extended release comprising microparticles comprising a polymer matrix comprising a linear and a branched polylactide-o-glycolide
polymer and pasireotide pamoate as an active ingredient produced by suspending pasireotide pamoate in a polymer solution, wherein said polymer solution comprises methylene chloride and a polymer mixture of said linear and said branched
polylactide-co-glycolide polymer, wherein the concentration of the polymer mixture in methylene chloride is 15.9% weight of polymer per weight of polymer solution, preparing an aqueous solution comprising a stabilizer, mixing the suspended pasireotide
pamoate in polymer solution with the stabilizer solution, evaporating off the methylene chloride, and filtering off the microparticles.
2. A process of making microparticles comprising--dissolving a mixture of a linear polylactide-co-glycolide polymer and a branched polylactide-co-glycolide polymer in methylene chloride to form a polymer solution wherein the concentration of the polymer mixture in methylene chloride is about 15.9 wt. % by weight of the polymer solution, adding the polymer solution to pasireotide pamoate to form a polymer solution comprising pasireotide pamoate, preparing an aqueous dispersion containing a stabilizer, mixing the polymer solution comprising pasireotide pamoate with the aqueous dispersion containing the stabilizer, evaporating the methylene chloride and filtering off the microparticles. |