Claims for Patent: 9,351,923

Summary for Patent: 9,351,923

Title:	Extended-release composition comprising a somatostatin derivative in microparticles
Abstract:	The present invention relates to improved microparticles comprising a somatostatin analog, a process of making said microparticles and to pharmaceutical compositions comprising the same.
Inventor(s):	Lambert; Olivier (Spechbach le Haut, FR), Riemenschnitter; Marc (Freiburg, DE), Vucenovic; Vitomir (Loerrach, DE)
Assignee:	Novartis AG (Basel, CH)
Application Number:	13/743,385
Patent Claims:	1. A pharmaceutical composition for extended release comprising microparticles comprising a polymer matrix comprising a linear and a branched polylactide-o-glycolide polymer and pasireotide pamoate as an active ingredient produced by suspending pasireotide pamoate in a polymer solution, wherein said polymer solution comprises methylene chloride and a polymer mixture of said linear and said branched polylactide-co-glycolide polymer, wherein the concentration of the polymer mixture in methylene chloride is 15.9% weight of polymer per weight of polymer solution, preparing an aqueous solution comprising a stabilizer, mixing the suspended pasireotide pamoate in polymer solution with the stabilizer solution, evaporating off the methylene chloride, and filtering off the microparticles. 2. A process of making microparticles comprising--dissolving a mixture of a linear polylactide-co-glycolide polymer and a branched polylactide-co-glycolide polymer in methylene chloride to form a polymer solution wherein the concentration of the polymer mixture in methylene chloride is about 15.9 wt. % by weight of the polymer solution, adding the polymer solution to pasireotide pamoate to form a polymer solution comprising pasireotide pamoate, preparing an aqueous dispersion containing a stabilizer, mixing the polymer solution comprising pasireotide pamoate with the aqueous dispersion containing the stabilizer, evaporating the methylene chloride and filtering off the microparticles.