Claims for Patent: 9,434,754
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Summary for Patent: 9,434,754
Title: | Use of an adrenal hormone-modifying agent |
Abstract: | The present invention relates to a method of treating a disease or disorder characterized by increased stress hormone levels and/or decreased androgen hormone levels in a subject, comprising administering to the subject a therapeutically effective amount of a compound represented by formula (I): wherein n is 1 or 3; R is hydrogen or --C(O)N(R.sub.a)(R.sub.b) wherein R.sub.a and R.sub.b are independently --(C.sub.1-C.sub.4) alkyl, or --(C.sub.1-C.sub.4) alkyl-(C.sub.5-C.sub.7) aryl, wherein each of R.sub.a and R.sub.b is optionally substituted by --(C.sub.1-C.sub.4) alkoxy; R.sub.1, R.sub.2, and R.sub.3, are independently hydrogen, halogen, cyano or --(C.sub.6-C.sub.10) aryl, wherein said --(C.sub.6-C.sub.10) aryl is optionally substituted by halogen, with the proviso that no more than one of R.sub.1, R.sub.2, and R.sub.3 is hydrogen; and R.sub.4 and R.sub.5 are hydrogen; or a pharmaceutically acceptable salt thereof. ##STR00001## |
Inventor(s): | Hu; Qi-Ying (Needham, MA), Ksander; Gary Michael (Amherst, MA), Meredith; Erik (Hudson, MA), Monovich; Lauren G (Belmont, MA), Papillon; Julien (Somerville, MA), Schumacher; Christoph (Bettingen, CH) |
Assignee: | Novartis AG (Basel, CH) |
Application Number: | 14/079,018 |
Patent Claims: | 1. A compound which is 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile dihydrogen phosphate; or a pharmaceutically acceptable salt thereof. |