Claims for Patent: 9,468,727

Summary for Patent: 9,468,727

Title:	Nasal delivery
Abstract:	A nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a delivery unit for delivering a flow entraining a substance to one nostril of a subject, the delivery unit including a nosepiece for fitting to a nostril of the subject; and a flow resistor unit for fitting to the other nostril of the subject, the flow resistor unit including a progressive resistor for progressively providing an increasing flow resistance to the delivered flow.
Inventor(s):	Djupesland; Per Gisle (Oslo, NO)
Assignee:	OptiNose AS (Oslo, NO)
Application Number:	14/094,250
Patent Claims:	1. A nasal delivery device for delivering a substance to a nostril of a subject, including: a nosepiece configured for fitting to a first nostril of the subject, the nosepiece comprising an inlet and an outlet; a mouthpiece through which the subject in use exhales; and a flow channel fluidly connecting the nosepiece and the mouthpiece, whereby exhaled air from an exhalation breath is delivered from the mouthpiece to the inlet, through the nosepiece, and out the outlet; a flow resistor disposed downstream of the mouthpiece and upstream of the outlet of the nosepiece to provide a predeterminable flow resistance to a delivered flow of exhalation breath. 2. The delivery device of claim 1, wherein the flow resistor is a progressive resistor for progressively providing an increasing flow resistance to the delivered flow. 3. The delivery device of claim 1, wherein the flow resistor is a fixed resistor for providing a predeterminable resistance to the delivered flow. 4. The delivery device of claim 1, further including: a substance supply unit which is actuatable to supply a substance. 5. The delivery device of claim 4, wherein the substance supply unit is configured to be actuatable to supply a substance at a predeterminable pressure. 6. The delivery device of claim 4, wherein the substance supply unit is configured to be actuatable to supply a substance at a predeterminable flow rate. 7. The delivery device of claim 4, wherein the substance supply unit is configured to be actuatable to supply a substance at one or both of a predeterminable pressure and a predeterminable flow rate. 8. The delivery device of claim 4, wherein the substance supply unit includes a dosing unit for supplying a substance. 9. The delivery device of claim 8, wherein the dosing unit comprises a nebulizer for supplying an aerosol. 10. The delivery device of claim 8, wherein the dosing unit comprises an aerosol canister for supplying an aerosol. 11. The delivery device of claim 8, wherein the dosing unit comprises a delivery pump unit for supplying an aerosol. 12. The delivery device of claim 11, wherein the delivery pump comprises a liquid pump unit for supplying a liquid aerosol. 13. The delivery device of claim 11, wherein the delivery pump a powder pump unit for supplying a powder aerosol. 14. The delivery device of claim 8, wherein the dosing unit comprises a powder delivery unit for delivering a powder aerosol. 15. The delivery device of claim 1, further including: a gas flow channel fluidly connected to the nosepiece through which a gas flow, separate from an exhalation breath of a subject, is in use delivered; and a gas supply unit for supplying a gas flow to the gas flow channel.