Claims for Patent: 9,474,746

Summary for Patent: 9,474,746

Title:	Methods for stabilizing oxidatively unstable compositions
Abstract:	Ophthalmic compositions and methods of preparing such compositions are disclosed.
Inventor(s):	Mahadevan; Shivkumar (Orange Park, FL), Molock; Frank (Orange Park, FL), Khanolkar; Vandeeta (Jacksonville, FL)
Assignee:	Johnson & Johnson Vision Care, Inc. (Jacksonville, FL)
Application Number:	13/894,482
Patent Claims:	1. An ophthalmic composition comprising a liquid, aerosol or gel which comprises, and an oxidatively unstable pharmaceutical ingredient selected from the group consisting of ketotifen, its pharmaceutically acceptable salts, nor ketotifen fumarate, and mixtures thereof and an effective amount of a stabilizing agent selected from the group consisting of diethylenetriaminepentaacetic acid and salts of diethylenetriaminepentaacetic acid wherein the ophthalmic composition has a pH of 6.6 to 7.2. 2. The ophthalmic composition of claim 1 wherein the effective amount of the stabilizing agent is about 2.5 .mu.moles/liter to about 5000 .mu.moles/liter. 3. The ophthalmic composition of claim 1 wherein the effective amount of the stabilizing agent is about 100 .mu.moles/liter to about 1000 .mu.moles/liter. 4. The ophthalmic composition of claim 1 wherein the effective amount of the stabilizing agent is about 100 .mu.moles/liter to about 600 .mu.moles/liter. 5. The ophthalmic composition of claim 1 wherein the stabilizing agent is diethylenetriaminepentaacetic acid. 6. The ophthalmic composition of claim 1 wherein the oxidatively unstable pharmaceutical ingredient is selected from the group consisting of ketotifen, its pharmaceutically acceptable salts, and mixtures thereof.