You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: November 8, 2024

Claims for Patent: 9,504,691

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 9,504,691

Title:	Finafloxacin suspension compositions
Abstract:	The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a suspension composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin free base or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections.
Inventor(s):	Boudreaux; Brent G. (Irving, TX), Bridle; Mark J. (Keller, TX), Huynh; Bryan H. (Fort Worth, TX), Ghosh; Malay (Fort Worth, TX), Chowhan; Masood A. (Arlington, TX), Alani; Laman (Fort Worth, TX), Kabra; Bhagwati P. (Euless, TX)
Assignee:	Alcon Research, Ltd. (Fort Worth, TX)
Application Number:	14/086,651
Patent Claims:	1. A topical suspension composition comprising finafloxacin, a solubilizer, and a suspending agent, and wherein said finafloxacin is finafloxacin free base form A, said solubilizer is magnesium salt at a concentration of 0.98 to 4.9 mM, and said suspending agent is hydroxyethylcellulose at a concentration of 0.1 to 0.3 w/v %, and wherein said composition maintains substantial uniformity for greater than 8 hours at 25.degree. C., and wherein said composition has a pH of 5.8 to 6.2 and said concentration of finafloxacin is 0.15 to 2.0 w/v %. 2. A composition according to claim 1, said composition having a ratio of suspended to solubilized finafloxacin between 18:1 and 1:1. 3. A composition according to claim 1, wherein said solubilizer is magnesium chloride at a concentration of 0.05 to 0.07 w/v %. 4. A composition according to claim 1, further comprising an anti-inflammatory agent. 5. A composition according to claim 4, wherein said anti-inflammatory agent is dexamethasone. 6. A composition according to claim 5, wherein said composition comprises dexamethasone at a concentration of 0.05 to 1.0 w/v %. 7. A method for treating an ophthalmic, otic, or nasal infection comprising: treating the infection with a pharmaceutically effective amount of a composition according to claim 1. 8. A method according to claim 7 wherein said infection is acute otitis externa or acute otitis media with tympanostomy tubes. 9. A method for preparing a finafloxacin suspension of claim 1 comprising: producing a finafloxacin slurry by adding finafloxacin free base, a milling agent, and milling beads together with water to form an aqueous slurry; and heating the slurry to form finafloxacin free base form A. 10. A method for preparing a finafloxacin suspension comprising: producing a finafloxacin slurry by adding finafloxacin free base, a milling agent, and milling beads together with water to form an aqueous slurry; and heating the slurry to form finafloxacin free base form A. 11. A method according to claim 10 wherein said finafloxacin slurry further comprises one or more anti-inflammatory agents. 12. A method according to claim 11 wherein said finafloxacin slurry further comprises dexamethasone.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.