Claims for Patent: 9,567,363

Summary for Patent: 9,567,363

Title:	Certain compounds, compositions and methods
Abstract:	The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
Inventor(s):	Hamilton; Gregory S. (Catonsville, MD), Tsukamoto; Takashi (Ellicott City, MD), Ferraris; Dana V. (Eldersberg, MD), Duvall; Bridget (Nottingham, MD), Lapidus; Rena (Baltimore, MD)
Assignee:	OTSUKA PHARMACEUTICAL CO., LTD. (Tokyo, JP)
Application Number:	14/584,437
Patent Claims:	1. A method of producing compound 1a: ##STR00044## or a pharmaceutically salt thereof; comprising reducing compound 25: ##STR00045## to produce compound 1a: ##STR00046## or a pharmaceutically salt thereof. 2. The method of claim 1, further comprising a step of purifying the final product by preparative HPLC. 3. The method of claim 1, wherein the reduction is carried out in the presence of sodium borohydride. 4. A method of producing compound 1a: ##STR00047## or a pharmaceutically salt thereof; comprising the steps of: (a) hydrogenating compound 24: ##STR00048## to produce compound 25: ##STR00049## and (b) reducing compound 25 to produce compound 1a: ##STR00050## or a pharmaceutically salt thereof. 5. The method of claim 4, further comprising a step of purifying the final product by preparative HPLC. 6. The method of claim 4, wherein step (a) is carried out in the presence of rhodium on alumina. 7. The method of claim 4, wherein step (b) is carried out in the presence of sodium borohydride. 8. A crystalline form of compound 1a: ##STR00051## 9. The crystalline form of compound 1a of claim 8, having a primitive trigonal cell with dimensions: a=9.78961(18) .ANG. c=20.4588(7) .ANG. V=1698.02(7) .ANG..