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Last Updated: December 24, 2024

Claims for Patent: 9,592,252


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Summary for Patent: 9,592,252
Title:Colonoscopy--preparation
Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 2000 mmol per liter ascorbate anion provided by ascorbic acid, one or more salts of ascorbic acid, or a mixture thereof; and b) 10 to 200 g per liter polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions. The invention also provides a method of cleansing the colon of a subject comprising: --administering to the subject an effective amount of a first cleansing solution; and then after a time interval --administering to the subject an effective amount of a second cleansing solution, where in the two cleansing solutions are as described in the specification.
Inventor(s): Halphen; Marc (London, GB), Gruss; Hans-Jurgen (London, GB), Cox; Ian (London, GB), Cockett; Alasdair (London, GB), Stein; Peter (Amsterdam, NL), Ungar; Alex (Wigton, GB)
Assignee: NORGINE BV (Amsterdam Zuid-Oost, NL)
Application Number:14/004,604
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 9,592,252
Patent Claims: 1. A colon cleansing solution comprising: a) 300 to 2000 mmol per liter ascorbate anion provided by ascorbic acid, one or more salts of ascorbic acid, or a mixture thereof; b) 10 to 200 g per liter polyethylene glycol; and c) sodium chloride and potassium chloride.

2. A colon cleansing solution as claimed in claim 1 wherein the ascorbate anion is provided by ascorbic acid, one or more salts of ascorbic acid selected from sodium ascorbate, potassium ascorbate, magnesium ascorbate and calcium ascorbate, or a mixture thereof.

3. A colon cleansing solution as claimed in claim 1 comprising: a) 300 to 2000 mmol per liter ascorbate anion; b) 10 to 200 g per liter PEG having an average molecular weight of 3000 to 4000 Dalton (Da); c) sodium chloride and potassium chloride; d) optionally one or more flavouring agents; and e) optionally one or more sweeteners.

4. A kit comprising: a first colon cleansing solution, and a second colon cleansing solution, the second colon cleansing solution being a solution in water of: a) 300 to 2000 mmol per liter ascorbate anion provided by ascorbic acid, one or more salts of ascorbic acid, or a mixture thereof; b) 10 to 200 g per liter polyethylene glycol; and c) sodium chloride and potassium chloride.

5. A kit as claimed in claim 4 wherein the first colon cleansing solution comprises: (i) 70 to 250 g per liter PEG having an average molecular weight of 2500 to 4500 Da; (ii) 2.0 to 20 g per liter of one or more alkali metal sulphates, alkaline earth metal sulphates or a mixture thereof; (iii) optionally one or more electrolytes; (iv) optionally one or more flavouring agents; and (v) optionally one or more sweeteners.

6. A kit comprising: A) a first component, being a composition for the preparation of a first colon cleansing solution by admixture with water; and B) a second component, being a composition for the preparation of a second colon cleansing solution by admixture with water; and optional instructions for use, the second colon cleansing solution being a second colon cleansing solution as defined in claim 4.

7. A kit as claimed in claim 6 comprising: A) a first component, being a composition for the preparation of a first colon cleansing solution comprising: (i) 70 to 250 g per liter PEG having an average molecular weight of 2500 to 4500 Da; (ii) 2 to 20 g per liter of one or more alkali metal sulphates, alkaline earth metal sulphates or a mixture thereof; (iii) optionally one or more electrolytes; (iv) optionally one or more flavouring agents; (v) optionally one or more sweeteners; and B) a second component, being a composition optionally presented in two or more parts for the preparation of a second colon cleansing solution, comprising: a) 300 to 2000 mmol per liter ascorbate anion; b) 10 to 200 g per liter polyethylene glycol; and c1) sodium chloride and potassium chloride; the first solution being different from the second.

8. A colon cleansing solution as claimed in claim 1 comprising the ascorbate component at 80 to 120 g per liter.

9. A colon cleansing solution as claimed in claim 1 comprising PEG at 30 to 90 g per liter.

10. A method of cleansing the colon of a subject comprising administering to the subject an effective amount of a colon cleansing solution as defined in claim 1.

11. A method of cleansing the colon of a subject comprising: administering to the subject an effective amount of a first colon cleansing solution; administering to the subject an effective amount of a second colon cleansing solution; the second colon cleansing solution comprising: a) 300 to 2000 mmol per liter ascorbate anion provided by ascorbic acid, one or more salts of ascorbic acid, or a mixture thereof; b) 10 to 200 g per liter polyethylene glycol; and c) sodium chloride and potassium chloride.

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