Claims for Patent: 9,724,342

Summary for Patent: 9,724,342

Title:	C-met modulator pharmaceutical compositions
Abstract:	Pharmaceutical compositions and unit dosage forms comprising Compound I are disclosed. ##STR00001##
Inventor(s):	Wilson; Jo Ann (San Francisco, CA), Shah; Khalid (Half Moon Bay, CA)
Assignee:	Exelixis, Inc. (South San Francisco, CA)
Application Number:	13/810,537
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 9,724,342
Patent Claims:	1. A tablet pharmaceutical composition comprising about: TABLE-US-00008 Ingredient (% w/w) Compound I, L-malate salt 31.68 Microcrystalline Cellulose 38.85 Lactose anhydrous 19.42 Hydroxypropyl Cellulose 3.00 Croscarmellose Sodium 3.00 Total Intra-granular 95.95 Silicon dioxide, Colloidal 0.30 Croscarmellose Sodium 3.00 Magnesium Stearate 0.75 Total 100.00 wherein Compound I is: ##STR00005## Compound I. 2. A tablet pharmaceutical composition comprising: 30-32 percent by weight of Compound I, L-malate salt wherein Compound I is: ##STR00006## 38-40 percent by weight of microcrystalline cellulose; 18-22 percent by weight of lactose; 2-4 percent by weight of hydroxypropyl cellulose; 4-8 percent by weight of croscarmellose sodium; 0.2-0.6 percent by weight of colloidal silicon dioxide; and 0.5-1 percent by weight of magnesium stearate. 3. The tablet pharmaceutical composition of claim 2, further comprising a film coating containing hypromellose, titanium dioxide, triacetin, and iron oxide yellow. 4. The tablet pharmaceutical composition of claim 1, further comprising a film coating containing hypromellose, titanium dioxide, triacetin, and iron oxide yellow. 5. The table pharmaceutical composition of claim 1, containing 20 to 100 mg of Compound I. 6. The tablet pharmaceutical composition of claim 1, containing 20, 25, 50, 60, 75, 80, or 100 mg of Compound I. 7. A tablet pharmaceutical composition comprising, based on 100 weight/weight percent: 30-32 percent by weight of Compound I, L-malate salt wherein Compound I is: ##STR00007## 38-40 percent by weight of microcrystalline cellulose; 18-22 percent by weight of lactose 2-4 percent by weight of hydroxypropyl cellulose; 4-8 percent by weight of croscarmellose sodium; 0.2-0.6 percent by weight of colloidal silicon dioxide; and 0.5-1 percent by weight of magnesium stearate; and further comprising a film coating containing hypromellose, titanium dioxide, triacetin, and iron oxide yellow. 8. The tablet pharmaceutical composition of claim 7, containing 20 to 100 mg of Compound I. 9. The tablet pharmaceutical composition of claim 7, containing 20, 25, 50, 60, 75, 80, or 100 mg of Compound I. 10. A tablet pharmaceutical composition comprising: TABLE-US-00009 Ingredient (% w/w) Compound I, L-malate 31.68 salt Microcrystalline Cellulose 38.85 Lactose anhydrous 19.42 Hydroxypropyl Cellulose 3.00 Croscarmellose Sodium 6.00 Silicon dioxide, Colloidal 0.30 Magnesium Stearate 0.75 Total 100.00. wherein Compound I is: ##STR00008## 11. The tablet pharmaceutical composition of claim 2, containing 20 to 100 mg of Compound I. 12. The tablet pharmaceutical composition of claim 2, containing 20, 25, 50, 60, 75, 80, or 100 mg of Compound I.