Claims for Patent: 9,763,577

Summary for Patent: 9,763,577

Title:	Imaging agent for detection of diseased cells
Abstract:	The present invention provides compositions and methods for imaging, for example, tumor resections.
Inventor(s):	Lee W. David, Bawendi Moungi G., Ferrer Jorge
Assignee:	Lumicell, Inc.
Application Number:	US14211014
Patent Claims:	2. The compound of claim 1 , wherein n is an integer between 440-460 claim 1 , inclusive.3. The compound of claim 1 , wherein the portion of the molecule defined by brackets (mPEG portion) is about 20 claim 1 ,000 g/mol in molecular weight.5. The compound of claim 1 , wherein the compound is provided as an acetate salt.6. A composition comprising one or more compounds of or a pharmaceutically acceptable salt thereof.7. A composition comprising a plurality of compounds of or a pharmaceutically acceptable salt thereof.8. The composition of claim 7 , wherein the average value of n for the compounds in the composition is between 440-460 claim 7 , inclusive.9. The composition of claim 7 , wherein the average value of n for the compounds in the composition is about 450.12. An in-vivo method for spatially determining tissue heterogeneity of tissue of a subject comprising:{'claim-ref': {'@idref': 'CLM-00006', 'claim 6'}, '(a) administering a composition of to the subject; and'}(b) obtaining after said administration step an in-situ image of said tissue.13. The in-vivo method of claim 12 , wherein the image is obtained using an imaging system having pixels with a field of view claim 12 , and wherein the field of view of each pixel when said image is obtained is one cell or less than one cell.14. The method of claim 12 , wherein the composition is administered systemically and the image is obtained between 12 and 72 hours after the composition is administered.15. The method of claim 12 , wherein the composition is administered systemically and the image is obtained between 12 and 36 hours after administration.16. The method of claim 12 , wherein the image distinguishes between diseased cells and healthy cells within 5 mm claim 12 , 4 mm claim 12 , 3 mm claim 12 , 2 mm claim 12 , or even 1 mm from the surface of the tissue.17. The method of claim 16 , wherein the image does not distinguish between diseased cells and healthy cells that are deeper than 5 mm claim 16 , 6 mm claim 16 , 7 mm claim 16 , 8 mm claim 16 , 9 mm claim 16 , or 10 mm from the surface of the tissue.18. The method of claim 12 , wherein the image distinguishes between diseased cells and healthy cells claim 12 , and the diseased cell is a cancer cell.19. The method of claim 12 , wherein the tissue is a tissue bed left behind after tumor resection.20. The method of claim 12 , wherein the subject is a human.21. The method of claim 12 , wherein the composition is administered topically in-vivo.