Claims for Patent: 9,795,560

Summary for Patent: 9,795,560

Title:	Aqueous ophthalmic solutions of phentolamine and medical uses thereof
Abstract:	The invention provides aqueous ophthalmic solutions of phentolamine or pharmaceutically acceptable salts thereof, medical kits, and methods for using such ophthalmic solutions to improve visual performance in a patient. Exemplary aqueous ophthalmic solutions include those containing phentolamine mesylate, mannitol, sodium acetate, and water.
Inventor(s):	Meyer Alan
Assignee:	Ocularis Pharma, LLC
Application Number:	US14169339
Patent Claims:	1. An aqueous ophthalmic solution , consisting of:(i) about 0.5% (w/v) to about 2% (w/v) of phentolamine mesylate;(ii) about 1% (w/v) to about 6% (w/v) of one or more polyol compounds selected from the group consisting of mannitol, glycerol, and propylene glycol;(iii) about 1 mM to about 6 mM of an alkali metal acetate;(iv) acetic acid; and(v) water;wherein the solution has a pH in the range of 4.5 to 5.5.2. The solution of claim 1 , wherein the solution consists of:(i) about 0.5% (w/v) to about 1% (w/v) of phentolamine mesylate;(ii) about 1% (w/v) to about 6% (w/v) of one or more polyol compounds selected from the group consisting of mannitol, glycerol, and propylene glycol;(iii) about 1 mM to about 6 mM of an alkali metal acetate;(iv) acetic acid; and(v) water;wherein the solution has a pH in the range of 4.5 to 5.5.3. An aqueous ophthalmic solution claim 1 , consisting of:a. about 0.25% (w/v) to about 2% (w/v) of phentolamine mesylate;b. about 3% (w/v) to about 5% (w/v) of mannitol;c. about 2 mM to about 4 mM of sodium acetate; andd. water;wherein the solution has a pH in the range of 4.5 to 5.2.4. An aqueous ophthalmic solution claim 1 , consisting of:a. about 0.5% (w/v) to about 1% (w/v) of phentolamine mesylate;b. about 4% mannitol;c. about 3 mM sodium acetate; and 'wherein the solution has a pH in the range of 4.6 to 5.2.', 'd. water;'}