Claims for Patent: 9,855,211

Summary for Patent: 9,855,211

Title:	Topical compositions and methods of using the same
Abstract:	The present invention relates generally to topical compositions and methods of using the same.
Inventor(s):	Doxey Ryan, Sabouni Adam, Kougoulos Eleftherios, Stasko Nathan
Assignee:	Novan, Inc.
Application Number:	US14191958
Patent Claims:	1. A composition comprising:an aqueous composition in an admixture with an anhydrous composition in a ratio of the aqueous composition to the anhydrous composition of about 3:1 or less; a first viscosity increasing agent in an amount of 0.6% to 5% by weight of the aqueous composition, wherein the first viscosity increasing agent is a cellulose ether or a carboxypolymethylene;', 'at least one polyhydric alcohol in an amount of 1% to 30% by weight of the aqueous composition;', 'at least one buffering agent;', 'water; and', 'optionally at least one preservative;, 'wherein the aqueous composition is a buffered hydrogel and comprises a second viscosity increasing agent in an amount of 0.5% to 30% by weight of the anhydrous composition;', 'at least one alcohol in an amount of 50% to 90% by weight of the anhydrous composition;', 'at least one humectant in an amount of 2% to 20% by weight of the anhydrous composition; and', 'diazeniumdiolate modified polysiloxane macromolecules comprising a co-condensed siloxane network., 'wherein the anhydrous composition is an alcohol gel and comprises2. The composition of claim 1 , wherein the aqueous composition is in the admixture with the anhydrous composition in a ratio of about 3:1.3. The composition of claim 1 , further comprising at least one water repellant.4. The composition of claim 1 , further comprising at least one neutralizing agent.5. The composition of claim 1 , wherein the composition has a pH of about 3 to about 8 when topically applied to skin of a subject.6. The composition of claim 1 , wherein the composition is cosmetically elegant.7. The composition of claim 1 , wherein the diazeniumdiolate modified polysiloxane macromolecules release nitric oxide in an amount of at least 50% over a period of time of about 3 hours or less after topical application of the composition to skin of a subject.8. A kit comprising: at least one polyhydric alcohol present in an amount of 1% to 30% by weight of the hydrogel;', 'a first viscosity increasing agent present in an amount of 0.6% to 5% by weight of the hydrogel, wherein the first viscosity increasing agent is a cellulose ether or a carboxypolymethylene;', 'at least one buffering agent; and', 'water; and, 'a buffered hydrogel having a pH in a range of 3 to 6.5 and comprising diazeniumdiolate modified polysiloxane macromolecules comprising a co-condensed siloxane network;', 'a second viscosity increasing agent present in the anhydrous alcohol gel in an amount of 0.5% to 30% by weight of the anhydrous alcohol gel;', 'at least one alcohol present in the anhydrous alcohol gel in an amount of about 50% to about 90% by weight of the anhydrous alcohol gel; and', 'at least one humectant present in the anhydrous alcohol gel in an amount of about 2% to about 20% by weight of the anhydrous alcohol gel., 'an anhydrous alcohol gel comprising9. The kit of claim 8 , wherein the buffered hydrogel and the anhydrous alcohol gel are separately stored.10. A method of increasing the release of nitric oxide from the anhydrous alcohol gel of comprising:{'claim-ref': {'@idref': 'CLM-00008', 'claim 8'}, 'contacting the anhydrous alcohol gel with the buffered hydrogel of to provide a combined composition; and'}applying the combined composition to the skin of a subject.11. The composition of claim 1 , wherein the aqueous composition is in the admixture with the anhydrous composition in a ratio of about 1:1.12. The composition of claim 1 , wherein the first viscosity increasing agent comprises a carboxypolymethylene claim 1 , the at least one polyhydric alcohol is glycerin claim 1 , the at least one buffering agent is lactic acid claim 1 , and water is present in an amount of about 70% to about 99% by weight of the aqueous composition.13. The composition of claim 1 , wherein the first viscosity increasing agent comprises a carboxymethyl cellulose claim 1 , the at least one polyhydric alcohol is glycerin claim 1 , and the at least one buffering agent comprises potassium phosphate.14. The composition of claim 1 , wherein the second viscosity increasing agent is hydroxypropyl cellulose claim 1 , the at least one alcohol is ethyl alcohol or isopropyl alcohol claim 1 , and the at least one humectant is hexylene glycol.15. The composition of claim 1 , wherein the at least one alcohol is isopropyl alcohol and the composition further comprises cyclomethicone.16. The composition of claim 14 , wherein the first viscosity increasing agent comprises a carboxypolymethylene claim 14 , the at least one polyhydric alcohol is glycerin claim 14 , and the at least one buffering agent is lactic acid.17. The composition of claim 14 , wherein the first viscosity increasing agent comprises a carboxymethyl cellulose claim 14 , the at least one polyhydric alcohol is glycerin claim 14 , and the at least one buffering agent comprises potassium phosphate.18. The composition of claim 1 , wherein the buffered hydrogel has a pH in a range of about 3 to about 6.5.19. The composition of claim 1 , wherein the composition comprising the aqueous composition and the anhydrous composition is buffered to a pH of about 3 to about 8 for at least 5 minutes.20. The composition of claim 1 , wherein the composition comprising the aqueous composition and the anhydrous composition is buffered to a pH of about 3 to about 8 for at least 60 minutes.21. The kit of claim 8 , wherein the second viscosity increasing agent is hydroxypropyl cellulose claim 8 , the at least one alcohol is ethyl alcohol or isopropyl alcohol claim 8 , and the at least one humectant is hexylene glycol.22. The kit of claim 21 , wherein the at least one alcohol is isopropyl alcohol and the anhydrous alcohol gel further comprises cyclomethicone.23. The kit of claim 8 , wherein the first viscosity increasing agent comprises a carboxypolymethylene claim 8 , the at least one polyhydric alcohol is glycerin claim 8 , and the at least one buffering agent is lactic acid.24. The kit of claim 8 , wherein the first viscosity increasing agent comprises a carboxymethyl cellulose claim 8 , the at least one polyhydric alcohol is glycerin claim 8 , and the at least one buffering agent comprises potassium phosphate.