Claims for Patent: 9,884,039
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Summary for Patent: 9,884,039
Title: | Pharmaceutical formulations for subcutaneous administration of furosemide |
Abstract: | The present teachings relate to liquid pharmaceutical formulations of furosemide, where the pharmaceutical formulations include a molar excess of tris(hydroxymethyl)aminomethane to furosemide, have a pH in the range of 7 to 8.5, and a concentration of tris(hydroxymethyl)aminomethane greater than or equal to about 50 mM. The present teachings can improve the stability of liquid pharmaceutical formulations including furosemide and the suitability of such pharmaceutical formulations for subcutaneous administration or delivery. |
Inventor(s): | Michaels Scott A., Muntendam Pieter, Larsen Glenn R. |
Assignee: | scPharmaceuticals Inc. |
Application Number: | US14781706 |
Patent Claims: | 2. The method of claim 1 , wherein administering comprises administering subcutaneously the pharmaceutical formulation.3. The method of claim 2 , wherein administering subcutaneously comprises using a pump device.4. The method of claim 3 , wherein the pump device is a patch device.5. The method of claim 1 , wherein administering comprises administering intravenously the liquid pharmaceutical formulation.7. The method of claim 1 , wherein the amount of furosemide in the liquid pharmaceutical formulation is between about 2 mg/mL to about 10 mg/mL.8. The method of claim 1 , wherein the amount of furosemide in the liquid pharmaceutical formulation is between about 6 mg/mL to about 10 mg/mL.9. The method of claim 6 , wherein administering subcutaneously comprises using a pump device.10. The method of claim 9 , wherein the pump device is a patch device.12. The method of claim 11 , wherein the molar ratio of tris(hydroxymethyl)aminomethane to furosemide is greater than or equal to two.13. The method of claim 11 , wherein the concentration of tris(hydroxymethyl)aminomethane in the liquid pharmaceutical formulation is in a range of about 50 mM to about 250 mM.14. The method of claim 12 , wherein the concentration of tris(hydroxymethyl)aminomethane in the liquid pharmaceutical formulation is in a range of about 50 mM to about 250 mM.15. The method of claim 11 , wherein the liquid pharmaceutical formulation has a pH between about 7.2 to about 8.16. The method of claim 12 , wherein the liquid pharmaceutical formulation has a pH between about 7.2 to about 8.17. The method of claim 13 , wherein the liquid pharmaceutical formulation has a pH between about 7.2 to about 8.18. The method of claim 13 , wherein the liquid pharmaceutical formulation has a pH between about 7.2 to about 8.19. The method of claim 11 , wherein the amount of furosemide in the liquid pharmaceutical formulation is between about 2 mg/mL to about 15 mg/mL.20. The method of claim 12 , wherein the amount of furosemide in the liquid pharmaceutical formulation is between about 2 mg/mL to about 15 mg/mL.21. The method of claim 13 , wherein the amount of furosemide in the liquid pharmaceutical formulation is between about 2 mg/mL to about 15 mg/mL.22. The method of claim 15 , wherein the amount of furosemide in the liquid pharmaceutical formulation is between about 2 mg/mL to about 15 mg/mL.23. The method of claim 18 , wherein administering subcutaneously comprises using a pump device. |
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