Claims for Patent: 9,895,385
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Summary for Patent: 9,895,385
| Title: | Methods for treating pulmonary non-tuberculous mycobacterial infections |
| Abstract: | Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and/or NTM culture conversion to negative during or after the administration period. |
| Inventor(s): | Eagle; Gina (Morristown, NJ), Gupta; Renu (Moorestown, NJ) |
| Assignee: | INSMED INCORPORATED (Bridgewater, NJ) |
| Application Number: | 14/713,926 |
| Patent Claims: |
