Claims for Patent: RE29668

Summary for Patent: RE29668

Title:	Glycineamides
Abstract:	A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50.degree.-150.degree. C., said products being antiinflammatory agents. .Iadd.
Inventor(s):	Lombardino; Joseph G. (Niantic, CT)
Assignee:	Pfizer Inc. (New York, NY)
Application Number:	05/780,312
Patent Claims:	1. A process for the preparation of a compound of the formula: ##STR10## wherein R.sub.1 is selected from the group consisting of phenyl; monosubstituted phenyl wherein said substituent is selected from the group consisting of fluoro, chloro, methyl and methoxy; 2-thiazolyl; 4,5-dimethyl-2-thiazolyl; 2-pyridyl; 6-methyl-2-pyridyl, and 5-methyl-3-isoxazolyl; R.sub.2 is alkyl containing from 1 to 3 carbon atoms; and X is substituent selected from the group consisting of hydrogen, methyl, methoxy, fluoro, chloro and bromo, which comprises contacting a compound of the formula: ##STR11## wherein R.sub.3 is alkyl containing from 1 to 3 carbon atoms, with a metal hydride selected from the group consisting of alkali and alkaline earth metal hydrides, in a reaction-inert solvent at 50.degree.-150.degree. C..]. .[.2. The process of claim 1 wherein the metal hydride is sodium hydride..]. .[.3. The process of claim 2 wherein the solvent is tetrahydrofuran..]. .[.4. The process of claim 3 wherein X is hydrogen, and R.sub.2 and R.sub.3 are each methyl..]. .[.5. The process of claim 4 wherein R.sub.1 is phenyl..]. .[.6. The process of claim 4 wherein R.sub.1 is 2-thiazolyl..]. .[.7. The process of claim 4 wherein R.sub.1 is 6-methyl-2-pyridyl..]. .[.8. The process of claim 4 wherein R.sub.1 is 2-pyridyl..]. .Iadd. 9. A compound of the formula and the dihydrobromide salts thereof wherein R.sub.1 is selected from the group consisting of phenyl; monosubstituted phenyl wherein said substituent is selected from the group consisting of fluoro, chloro, methyl and methoxy; 2-thiazolyl; 4,5-dimethyl-2-thiazolyl; 2-pyridyl; 6-methyl-2-pyridyl, and 5-methyl-3-isoxazolyl and R.sub.2 is alkyl having from 1 to 3 carbon atoms. .Iaddend..Iadd. 10. The compound according to claim 9, wherein R.sub.1 is 2-thiazolyl and R.sub.2 is methyl. .Iaddend.