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Last Updated: December 22, 2024

Details for Patent: 10,696,660


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Summary for Patent: 10,696,660
Title:Rho kinase inhibitors
Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCK1 and/or ROCK2.
Inventor(s): Poyurovsky; Masha V. (New York, NY), Kim; Ji-In (Princeton, NJ), Liu; Kevin G. (West Windsor, NJ), Zanin-Zhorov; Alexandra (Staten Island, NY)
Assignee: Kadmon Corporation, LLC (New York, NY)
Application Number:16/251,952
Patent Claim Types:
see list of patent claims
Use;
Patent landscape, scope, and claims:

Understanding the Scope and Claims of United States Patent 10,696,660: A Detailed Analysis

Introduction

Patents are a crucial component of innovation, providing inventors with exclusive rights to their creations. The United States Patent 10,696,660, titled "Rho kinase inhibitors," is a significant patent in the field of pharmaceuticals. This article will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Overview of the Patent

Invention Description

The patent US10,696,660 pertains to inhibitors of Rho kinase (ROCK) enzymes, specifically ROCK1 and ROCK2. These inhibitors are designed to treat various diseases and disorders associated with the activity of these enzymes. Rho kinases play a critical role in several cellular processes, including cell proliferation, migration, and contraction, making their inhibitors potential therapeutic agents for conditions such as cardiovascular diseases, neurological disorders, and cancer[4].

Scope of the Patent

Technological Field

This patent falls under the broad technology area of chemistry, specifically within the subfield of pharmaceuticals. The World Intellectual Property Organization (WIPO) classification system, which is used by the USPTO, categorizes such patents under the International Patent Classification (IPC) technical fields related to organic chemistry and pharmaceutical compositions[1].

Claims

The patent includes a series of claims that define the scope of the invention. These claims are divided into independent and dependent claims. Independent claims stand alone and define the invention broadly, while dependent claims further specify the invention by adding additional limitations to the independent claims.

  • Independent Claims: These claims outline the core aspects of the Rho kinase inhibitors, including their chemical structure and the methods of treating diseases using these inhibitors.
  • Dependent Claims: These claims provide more detailed descriptions of the inhibitors, such as specific chemical modifications, dosages, and methods of administration[4].

Claims Analysis

Claim Structure

The claims in the patent are structured to ensure broad protection while also providing specificity to distinguish the invention from prior art. For example, Claim 1 might describe a general class of Rho kinase inhibitors, while subsequent claims narrow down to specific compounds or methods of use.

Claim Scope

The scope of the claims is critical in determining the patent's enforceability and the extent of protection it offers. The claims must be clear, concise, and supported by the patent's specification to avoid issues of ambiguity or invalidity. In the case of US10,696,660, the claims are carefully crafted to cover a range of inhibitors and their therapeutic applications, ensuring a robust protection for the inventors[3].

Patent Landscape

Global Trends

The patent landscape for pharmaceuticals, particularly in the area of enzyme inhibitors, is highly competitive and dynamic. Global trends indicate a significant increase in patent filings in the life sciences sector, driven by advancements in biotechnology and the need for innovative treatments for various diseases. The USPTO has seen a substantial rise in patent applications and grants in the technology areas related to chemistry and pharmaceuticals[1].

USPTO Patent Activity

In 2018, the USPTO awarded nearly 309,000 utility patents, with a significant portion in the fields of electrical engineering and chemistry. Patents related to instruments, chemistry, and other fields, including pharmaceuticals, made up a considerable share of the total patents granted. This trend highlights the importance of intellectual property in driving innovation in these sectors[1].

Inventorship and Ownership

Determining Inventorship

Correctly identifying the inventors is crucial for the validity and enforceability of a patent. US patent law requires that only the "true and only" inventors be listed on the patent application. Errors in inventorship, especially those involving deceptive intent, can render the patent unenforceable. Ensuring accurate inventorship is a critical step in the patent application process to avoid legal challenges later on[2].

Ownership Distribution

The ownership of patents, including those in the pharmaceutical sector, is often distributed among various entities. Businesses receive the majority of patents, followed by individuals, academic institutions, and government sectors. In the case of US10,696,660, understanding the ownership structure is essential for licensing, collaboration, and enforcement purposes[1].

Economic and Legal Implications

Economic Impact

Patents like US10,696,660 have significant economic implications. They can drive investment in research and development, create new market opportunities, and contribute to the overall economic growth. The exclusive rights granted by the patent allow the inventors or assignees to recoup their investment in research and development, thereby incentivizing further innovation[3].

Legal Considerations

The legal landscape surrounding patents is complex and evolving. Patents must be carefully drafted to withstand legal challenges, including those related to inventorship, claim scope, and prior art. The enforceability of a patent depends on its validity, which can be challenged in court. Therefore, thorough legal counsel is essential in the patent application and maintenance process[2].

Key Takeaways

  • Patent Scope: The patent US10,696,660 covers Rho kinase inhibitors and their therapeutic applications, with claims structured to provide broad and specific protection.
  • Claims Analysis: The claims are critical in defining the invention and must be clear, concise, and supported by the specification.
  • Patent Landscape: The patent is part of a highly competitive and dynamic landscape in the pharmaceutical sector, with global trends showing an increase in patent filings.
  • Inventorship and Ownership: Correct inventorship is essential for the patent's validity, and understanding the ownership structure is crucial for licensing and enforcement.
  • Economic and Legal Implications: The patent has significant economic implications and must be legally sound to withstand challenges.

FAQs

What is the main subject of the patent US10,696,660?

The main subject of the patent US10,696,660 is inhibitors of Rho kinase (ROCK) enzymes, specifically ROCK1 and ROCK2, and their use in treating various diseases.

How are the claims structured in the patent?

The claims are structured into independent and dependent claims, with independent claims defining the core aspects of the invention and dependent claims providing additional specificity.

Why is correct inventorship important for a patent?

Correct inventorship is crucial because errors, especially those involving deceptive intent, can render the patent unenforceable.

What is the economic impact of patents like US10,696,660?

Patents like US10,696,660 can drive investment in research and development, create new market opportunities, and contribute to overall economic growth.

How does the USPTO classify patents in the pharmaceutical sector?

The USPTO classifies patents in the pharmaceutical sector using the World Intellectual Property Organization (WIPO) classification system, which includes 35 International Patent Classification (IPC) technical fields.

Sources

  1. Invention: U.S. and Comparative Global Trends. National Science Foundation, 15 Jan 2020.
  2. Determining Inventorship for US Patent Applications. Oregon State University, AgSci.
  3. Patent Claims Research Dataset. U.S. Patent and Trademark Office, 28 Aug 2017.
  4. Rho kinase inhibitors. Google Patents, US10,696,660 B2.

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Drugs Protected by US Patent 10,696,660

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Kadmon Pharms Llc REZUROCK belumosudil mesylate TABLET;ORAL 214783-001 Jul 16, 2021 RX Yes Yes ⤷  Subscribe ⤷  Subscribe FOR THE TREATMENT OF CHRONIC GRAFT VERSUS HOST DISEASE ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 10,696,660

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 2903618 ⤷  Subscribe SPC/GB22/068 United Kingdom ⤷  Subscribe
Canada 2926478 ⤷  Subscribe
Canada 3151343 ⤷  Subscribe
China 105120869 ⤷  Subscribe
China 113620933 ⤷  Subscribe
China 113637007 ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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