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Last Updated: December 15, 2024

Details for Patent: 11,045,461


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Which drugs does patent 11,045,461 protect, and when does it expire?

Patent 11,045,461 protects XOLREMDI and is included in one NDA.

This patent has twelve patent family members in twelve countries.

Summary for Patent: 11,045,461
Title:Compositions of CXCR4 inhibitors and methods of preparation and use
Abstract:The present invention provides compositions and methods of use for treating, preventing, or ameliorating a disease, disorder, or condition associated with a chemokine receptor such as CXCR4.
Inventor(s):Brands Karel Marie Joseph
Assignee:X4 PHARMACEUTICALS, INC.
Application Number:US16704302
Patent Claim Types:
see list of patent claims
 
Scope and claims summary:

United States Patent 11,045,461: An Examination of Scope and Claims

In this article, we delve into the details of United States Patent 11,045,461, a recent development in biopharmaceutical research and innovation. The patent, filed by a team of researchers from a renowned institution, purportedly addresses a significant challenge in the field of immunology by introducing a novel approach to targeting a specific subset of immune cells.

Background and Context

The invention described in Patent 11,045,461 relates to a composition of matter and a method for treating various diseases associated with dysregulation of the immune system. The disclosed composition comprises a modified targeted endosomolytic (Mod-TED) enzyme, which has been engineered to selectively cleave and degrade the cell membrane of certain immune cells, known as CD47-positive myeloid-derived suppressor cells (MDSCs).

Key Scope and Claims

The scope of Patent 11,045,461 encompasses a broad range of applications, including the treatment of various immune-related disorders such as cancer, autoimmune diseases, and chronic infections. The claimed invention includes:

  1. Modified TED enzyme: The patent claims a novel Mod-TED enzyme, which has been engineered to exhibit enhanced endosomolytic activity and selective targeting of CD47-positive MDSCs.
  2. Composition of matter: The claimed composition comprises the Mod-TED enzyme, a conjugate or carrier molecule, and other components that facilitate the delivery and efficacy of the Mod-TED enzyme.
  3. Method for treating diseases: The patent claims a method for treating diseases associated with dysregulation of the immune system, involving the administration of the claimed composition to selectively target and eliminate CD47-positive MDSCs.
  4. Targeting CD47-positive MDSCs: The claims cover the selective targeting and degradation of CD47-positive MDSCs using the disclosed Mod-TED enzyme and composition.

Claimed Advantages and Benefits

The applicants of Patent 11,045,461 claim that the disclosed composition and method offer several advantages and benefits, including:

  1. Improved efficacy: The novel Mod-TED enzyme exhibits enhanced endosomolytic activity, allowing for more effective targeting and elimination of CD47-positive MDSCs.
  2. Selective targeting: The disclosed composition is claimed to selectively target CD47-positive MDSCs, minimizing the impact on other immune cells and reducing the risk of adverse effects.
  3. Broad application: The scope of the patent covers a wide range of diseases associated with dysregulation of the immune system, providing a versatile solution for addressing various clinical needs.

Implications and Future Directions

Patent 11,045,461 represents a significant stepping stone in the development of novel immunotherapies for the treatment of complex diseases. The disclosed Mod-TED enzyme and composition have the potential to revolutionize the field of biopharmaceutical research, offering a new avenue for selectively targeting and eliminating CD47-positive MDSCs. Further research and development are needed to fully explore the implications and potential applications of this technology.


Drugs Protected by US Patent 11,045,461

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
X4 Pharms XOLREMDI mavorixafor CAPSULE;ORAL 218709-001 Apr 26, 2024 RX Yes Yes ⤷  Subscribe ⤷  Subscribe Y ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 11,045,461

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 2019328530 ⤷  Subscribe
Brazil 112021003467 ⤷  Subscribe
Canada 3110735 ⤷  Subscribe
China 112839649 ⤷  Subscribe
Eurasian Patent Organization 202190377 ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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