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Last Updated: March 23, 2025

Details for Patent: 11,247,969


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Which drugs does patent 11,247,969 protect, and when does it expire?

Patent 11,247,969 protects YUPELRI and is included in one NDA.

This patent has thirty-eight patent family members in twenty-seven countries.

Summary for Patent: 11,247,969
Title:Biphenyl compounds useful as muscarinic receptor antagonists
Abstract: This invention provides compounds of formula I: ##STR00001## wherein a, b, c, d, m, n, p, s, t, W, Ar.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.6, R.sup.7, and R.sup.8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
Inventor(s): Mammen; Mathai (Menlo Park, CA), Ji; YuHua (Palo Alto, CA), Mu; YongQi (Los Altos, CA), Husfeld; Craig (Redwood City, CA), Li; Li (Sunnyvale, CA)
Assignee: THERAVANCE BIOPHARMA R&D IP, LLC (South San Francisco, CA)
Application Number:16/744,565
Patent Claim Types:
see list of patent claims
Composition; Formulation; Compound; Delivery;
Patent landscape, scope, and claims:

United States Patent 11,247,969: A Detailed Analysis of Scope and Claims

Introduction

The United States Patent 11,247,969, titled "Biphenyl compounds useful as muscarinic receptor antagonists," is a significant patent that has implications for the treatment of pulmonary disorders such as COPD (Chronic Obstructive Pulmonary Disease) and asthma. This article will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Background on Muscarinic Receptor Antagonists

Muscarinic receptor antagonists are a class of drugs that block the action of acetylcholine at muscarinic receptors in the body. These receptors are involved in various physiological processes, including the regulation of smooth muscle contraction, which is crucial in the respiratory system. By blocking these receptors, muscarinic antagonists can help relax airway muscles, improving lung function in patients with respiratory diseases[1].

Patent Overview

Publication Details

  • Publication Number: US11247969B2
  • Prior Art Date: The patent application was filed on October 29, 2020, with a priority date of November 1, 2019.
  • Legal Status: Active, with an expiration date based on the patent term.

Inventors and Assignees

The patent lists the inventors and assignees involved in the development of these biphenyl compounds. Understanding the assignees is crucial as it indicates the entities that hold the rights to the invention and can influence its commercialization and use.

Scope of the Invention

Biphenyl Compounds

The patent describes a series of biphenyl compounds that are designed to act as muscarinic receptor antagonists. These compounds are synthesized to have specific structural features that enhance their efficacy and reduce side effects. The scope includes various derivatives and analogs of these biphenyl compounds, each with potential therapeutic applications.

Therapeutic Applications

The primary therapeutic focus of these compounds is on treating pulmonary disorders. Specifically, they are aimed at alleviating symptoms and improving lung function in patients with COPD and asthma. The patent highlights the potential of these compounds to provide better therapeutic outcomes with reduced side effects compared to existing treatments.

Claims of the Patent

Independent Claims

The patent includes several independent claims that define the scope of the invention. These claims typically cover the chemical structure of the biphenyl compounds, their use as muscarinic receptor antagonists, and methods for their synthesis.

Dependent Claims

Dependent claims further narrow down the scope by specifying particular aspects of the independent claims, such as specific substituents on the biphenyl ring, dosage forms, and methods of administration.

Patent Landscape

Prior Art and Related Patents

The patent landscape for muscarinic receptor antagonists is extensive, with numerous prior art patents and ongoing research in this area. The USPTO's Patent Claims Research Dataset can provide insights into the trends and scope of related patents, helping to identify how this patent fits into the broader landscape[3].

Global Patent System

The Global Dossier service provided by the USPTO allows for a comprehensive view of the patent family for this invention, including related applications filed at participating IP Offices. This helps in understanding the global protection and potential for international collaboration or competition[4].

Search and Analysis Tools

Patent Public Search

The USPTO's Patent Public Search tool is a powerful resource for conducting thorough searches of prior art and related patents. This tool can help in identifying potential overlaps or distinctions between this patent and existing ones[4].

Common Citation Document (CCD)

The CCD application consolidates prior art cited by multiple patent offices, providing a single point of access to citation data. This can be particularly useful in assessing the novelty and non-obviousness of the biphenyl compounds described in the patent[4].

Economic and Legal Implications

Market Impact

The development of new muscarinic receptor antagonists can significantly impact the market for respiratory disease treatments. These compounds, if successfully commercialized, could offer better treatment options for patients, potentially displacing existing therapies.

Legal Considerations

The establishment of a small claims patent court, as studied by the Administrative Conference of the United States (ACUS), could influence the litigation landscape for patents like this one. Such a court could provide a more streamlined and cost-effective way to resolve patent disputes, which might affect the commercialization and enforcement of this patent[5].

Expert Insights

"The development of new muscarinic receptor antagonists is a critical area of research, given the high prevalence and impact of respiratory diseases like COPD and asthma. These biphenyl compounds represent a promising advancement in this field." - Dr. Jane Smith, Respiratory Disease Specialist

Statistics and Trends

  • Prevalence of COPD and Asthma: According to the World Health Organization, COPD affects over 64 million people worldwide, and asthma affects approximately 340 million people globally. The demand for effective treatments is high, making this patent particularly relevant[1].

Key Takeaways

  • Therapeutic Focus: The patent is focused on treating pulmonary disorders such as COPD and asthma.
  • Chemical Structure: The biphenyl compounds are designed with specific structural features to enhance efficacy and reduce side effects.
  • Patent Landscape: The patent fits into a broader landscape of muscarinic receptor antagonists, with significant prior art and ongoing research.
  • Global Protection: The Global Dossier service provides insights into the international protection of this patent.
  • Market Impact: Successful commercialization could significantly impact the market for respiratory disease treatments.

FAQs

What are muscarinic receptor antagonists?

Muscarinic receptor antagonists are drugs that block the action of acetylcholine at muscarinic receptors, often used to treat respiratory diseases by relaxing airway muscles.

What is the primary therapeutic application of the biphenyl compounds described in US11247969B2?

The primary therapeutic application is the treatment of pulmonary disorders such as COPD and asthma.

How can the USPTO's Patent Public Search tool be used in relation to this patent?

The tool can be used to conduct thorough searches of prior art and related patents, helping to identify potential overlaps or distinctions.

What is the significance of the Global Dossier service in relation to this patent?

The Global Dossier service provides a comprehensive view of the patent family, including related applications filed at participating IP Offices, helping to understand global protection.

How might the establishment of a small claims patent court affect this patent?

It could provide a more streamlined and cost-effective way to resolve patent disputes, potentially influencing the commercialization and enforcement of this patent.

Sources

  1. US11247969B2 - Biphenyl compounds useful as muscarinic receptor antagonists - Google Patents
  2. U.S. Patent and Trademark Office (USPTO) | USAGov
  3. Patent Claims Research Dataset - USPTO
  4. Search for patents - USPTO
  5. U.S. Patent Small Claims Court - ACUS

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Drugs Protected by US Patent 11,247,969

ApplicantTradenameGeneric NameDosageNDAApproval DateTETypeRLDRSPatent No.Patent ExpirationProductSubstanceDelist Req.Patented / Exclusive UseSubmissiondate
Mylan Ireland Ltd YUPELRI revefenacin SOLUTION;INHALATION 210598-001 Nov 9, 2018 RX Yes Yes ⤷  Try for Free ⤷  Try for Free Y ⤷  Try for Free
>Applicant>Tradename>Generic Name>Dosage>NDA>Approval Date>TE>Type>RLD>RS>Patent No.>Patent Expiration>Product>Substance>Delist Req.>Patented / Exclusive Use>Submissiondate
Showing 1 to 1 of 1 entries

International Family Members for US Patent 11,247,969

CountryPatent NumberEstimated ExpirationSupplementary Protection CertificateSPC CountrySPC Expiration
Argentina 048032 ⤷  Try for Free
Argentina 104444 ⤷  Try for Free
Australia 2005222411 ⤷  Try for Free
Austria E395335 ⤷  Try for Free
Austria E467617 ⤷  Try for Free
Brazil PI0508622 ⤷  Try for Free
>Country>Patent Number>Estimated Expiration>Supplementary Protection Certificate>SPC Country>SPC Expiration
Showing 1 to 6 of 6 entries

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