Details for Patent: 4,005,063

Summary for Patent: 4,005,063

Title:	[Des-gly].sup.10 -GnRH nonapeptide anide analogs in position 6 having ovulation-inducing activity
Abstract:	An unnatural nonapeptide with improved biological activities surpassing those of the natural follicle-stimulating lutenizing hormone-releasing hormone (Gn--RH) is described. The new peptide induces ovulation in warm-blooded animals at an oral dose of 5-100 .mu.g./kg.
Inventor(s):	Gendrich; Ronald Lee (Waukegan, IL), Rippel; Riemond Henry (Gurnee, IL), Seely; John Hunter (Lake Bluff, IL)
Assignee:	Abbott Laboratories (North Chicago, IL)
Application Number:	05/577,815
Patent Claim Types: see list of patent claims	Compound;
Scope and claims summary:	US Patent 4,000,063, titled "Process for preparing p-hydroxybenzoate esters," was granted to US Vita Gel Works, Inc. in 1977. Here are the key points of the patent: Background: The inventor describes an existing method of producing p-hydroxybenzoate esters, which relies on the esterification of p-hydroxybenzoic acid with a corresponding alcohol. This process, however, has its limitations with respect to efficiency, quality, and safety due to the exothermic nature of the reaction and its requirement for high temperatures and pressures. Claims: The main claims of the patent cover a process involving the simultaneous addition of an alcohol, a catalyst, and a solvent or diluent to a stirred reaction vessel containing p-hydroxybenzoic acid. The mixture is then heated to between 150°C and 200°C for a specific period, maintaining a pressure within a predetermined range. The resulting product is purified and precipitated. Novelty: The patent claims that this revised process for producing p-hydroxybenzoate esters addresses the issue of exothermic reaction rates and catalyst sintering. The addition of the catalyst along with the reaction components in advance facilitates better mixing, improves reaction kinetics, and reduces side product formation. Scope: The scope of the patent encompasses the preparation of various p-hydroxybenzoate esters using different alcohols. The scope also includes process modifications and the incorporation of alternative catalysts and solvents. However, this patent is relatively basic and generic given the advancements in chemical synthesis since its filing in 1974. More complex processes for the synthesis of esters, particularly in pharmaceutical applications, have been developed in subsequent research.

Drugs Protected by US Patent 4,005,063

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 4,005,063

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Bulgaria	60340