Details for Patent: 4,021,481

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Summary for Patent: 4,021,481

Title:	Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
Abstract:	This invention relates to novel X-ray contrast agents particularly for use in the cerebrospinal cavities, comprising non-ionic alkanols carrying at least one N-bonded secondary or tertiary amide group and having at least two hydroxyl groups and at least one iodine atom in the molecule. Particularly useful compounds include the N-hydroxyalkyl iodoalkane sulphonamides having at least two hydroxyl groups, tri- and tetra-iodobenzene carrying carbamoyl, acylamino and/or acylaminomethyl substituents and having at least two hydroxyl groups in the molecule and at least one N-hydroxyalkyl group. Particularly preferred compounds comprise 2,4,6-triiodobenzamides which may be 3- and/or 5-substituted with a variety of groups. The compounds all show markedly low toxicities and a number show very high levels of water solubility.
Inventor(s):	Almen; Torsten (Oslo, NO), Haavaldsen; Johan (Oslo, NO), Nordal; Vegard (Oslo, NO)
Assignee:	Nyegaard & Co. A/S (Oslo, NO)
Application Number:	05/528,842
Patent Claim Types: see list of patent claims	Compound;

Drugs Protected by US Patent 4,021,481

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
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Foreign Priority and PCT Information for Patent: 4,021,481

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
	32699/69	Jun 27, 1969
	6130/70	Feb 9, 1970

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