Details for Patent: 4,021,481
✉ Email this page to a colleague
Summary for Patent: 4,021,481
Title: | Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups |
Abstract: | This invention relates to novel X-ray contrast agents particularly for use in the cerebrospinal cavities, comprising non-ionic alkanols carrying at least one N-bonded secondary or tertiary amide group and having at least two hydroxyl groups and at least one iodine atom in the molecule. Particularly useful compounds include the N-hydroxyalkyl iodoalkane sulphonamides having at least two hydroxyl groups, tri- and tetra-iodobenzene carrying carbamoyl, acylamino and/or acylaminomethyl substituents and having at least two hydroxyl groups in the molecule and at least one N-hydroxyalkyl group. Particularly preferred compounds comprise 2,4,6-triiodobenzamides which may be 3- and/or 5-substituted with a variety of groups. The compounds all show markedly low toxicities and a number show very high levels of water solubility. |
Inventor(s): | Almen; Torsten (Oslo, NO), Haavaldsen; Johan (Oslo, NO), Nordal; Vegard (Oslo, NO) |
Assignee: | Nyegaard & Co. A/S (Oslo, NO) |
Application Number: | 05/528,842 |
Patent Claim Types: see list of patent claims | Compound; |
Drugs Protected by US Patent 4,021,481
Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
>Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 4,021,481
International Family Members for US Patent 4,021,481
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
---|---|---|---|---|---|
Austria | 318134 | ⤷ Sign Up | |||
Belgium | 752574 | ⤷ Sign Up | |||
Brazil | 7020080 | ⤷ Sign Up | |||
Canada | 935153 | ⤷ Sign Up | |||
Switzerland | 544551 | ⤷ Sign Up | |||
>Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |