Details for Patent: 4,559,222
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Summary for Patent: 4,559,222
Title: | Matrix composition for transdermal therapeutic system |
Abstract: | Mineral oil (MO) polyisobutylene (PIB), colloidal silicon dioxide (CSD) mixtures suitable for use as drug containing matrices in transdermal delivery systems are disclosed. Preferred systems for dispensing moderately mineral oil soluble drugs contain at least about 6% CSD, have a MO/PIB of at least 1.0 and a viscosity of at least 1.5.times.10.sup.7 poises. Preferred systems for dispensing clonidine have a clonidine permeability of at least 1.0.times.10.sup.-4 .mu.g/cm sec and a MO/PIB of at least 1.2. |
Inventor(s): | Enscore; David J. (Mountain View, CA), Gale; Robert M. (Mountain View, CA) |
Assignee: | ALZA Corporation (Palo Alto, CA) |
Application Number: | 06/491,490 |
Patent Claim Types: see list of patent claims | Composition; Delivery; |
Drugs Protected by US Patent 4,559,222
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