Details for Patent: 4,621,077

Summary for Patent: 4,621,077

Title:	Pharmacologically active biphosphonates, process for the preparation thereof and pharmaceutical compositions therefrom
Abstract:	Biphosphonic acids of general formula I: ##STR1## in which R is a fluorine atom of a linear or branched alkyl radical containing between 1 and 5 carbon atoms, which may also be substituted by one or more amino groups of fluorine atoms or both amino groups and fluorine atoms, R' is hydroxy or fluorine, and their salts with an alkali metal, an organic base or a basic aminoacid, exhibit valuable properties in the treatment of urolithiasis or in the treatment as inhibitors of bone reabsorption. The compound 4-amino-1-hydroxybutan-1,1-biphosphonic acid is between 100 and 300 times more active than Cl.sub.2 MDP.
Inventor(s):	Rosini; Sergio (Pisa, IT), Staibano; Giorgio (Pisa, IT)
Assignee:	Istituto Gentili S.p.A. (Pisa, IT)
Application Number:	06/618,578
Patent Claim Types: see list of patent claims	Use;

Drugs Protected by US Patent 4,621,077

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

Foreign Priority and PCT Information for Patent: 4,621,077

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
Italy	20781 A/82	Apr 15, 1982

International Family Members for US Patent 4,621,077

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Belgium	896453
Switzerland	661437
Germany	19675047
Germany	3313049
France	2525223
United Kingdom	2118042