Details for Patent: 4,837,223

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Summary for Patent: 4,837,223

Title:	(S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide compositions
Abstract:	(S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide, its preparation and pharmaceutical compositions containing the same. It can be prepared either by reacting (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetic acid successively with an alkyl haloformate and with ammonia, or, by cyclizing an (S)-2-amino-butanamide of the formula X--CH.sub.2 CH.sub.2 -NHCH (C.sub.2 H.sub.5)CONH.sub.2 wherein Y is a --CH.sub.2 --radical when X represents a ZOOC--radical and Y is a --CO-- radical when X represents a HalCH.sub.2 --radical, Z being a C.sub.1 -C.sub.4 alkyl radical and Hal a halogen atom. This laevorotatory enantiomer has been found to have significantly higher protective activity against hypoxia and ischemia than the corresponding racemate.
Inventor(s):	Gobert; Jean (Brussels, BE), Geerts; Jean-Pierre (Leglise, BE), Dodson; Guy (Bellefontaine, BE)
Assignee:	UCB Societe Anonyme (Brussels, BE)
Application Number:	07/025,277
Patent Claim Types: see list of patent claims	Composition; Compound; Process;

Drugs Protected by US Patent 4,837,223

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
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Foreign Priority and PCT Information for Patent: 4,837,223

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
United Kingdom	84/12357	May 15, 1984

International Family Members for US Patent 4,837,223

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