Details for Patent: 4,861,786

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Summary for Patent: 4,861,786

Title:	Composition for a stable vein compatible injectable solution of torasemide process for the preparation and method of use
Abstract:	The present invention provides an aqueous, alkaline injection solution of torasemide ready for injection, which contains a physiologically compatible alkaline buffer with a pH value of from 9.3 to 9.9 and with a buffer capacity of up to 0.1 val/liter together with an organic solvent in an amount of from 5 to 20% by weight selected from the group of polyethylene glycols with a molecular weight of from 100 to 1500, polypropylene glycols with a molecular weight of from 50 to 1000, glycerol, propylene glycol, ethanol and propanol, the torasemide being present in a concentration of from 2 to 40 mg/ml. Torasemide solutions are useful to inhibit inflammation or promote diuresis. The present invention also provides a process for the preparation of this solution, wherein torasemide is suspended in the above organic solvent brought into solution by the addition of aqueous alkali, adding the buffer and other adjuvants and adjusting the pH value to 9.3 to 9.9.
Inventor(s):	Demmer; Fritz (Hirschberg-Leutershausen, DE), Gruber; Werner (Birkenau, DE), Woog; Heinrich (Laudenbach, DE)
Assignee:	Boehringer Mannheim GmbH (Mannheim, DE)
Application Number:	07/071,201
Patent Claim Types: see list of patent claims	Composition; Formulation; Device; Process; Use;

Drugs Protected by US Patent 4,861,786

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

Foreign Priority and PCT Information for Patent: 4,861,786

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
Germany	3623620	Jul 12, 1986

International Family Members for US Patent 4,861,786

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