Details for Patent: 4,886,812

Summary for Patent: 4,886,812

Title:	Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals
Abstract:	This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nucleic may each be substituted by 1 or 2 halogen atoms, R.sub.2 represents a hydrogen atom or an alkyl group, R.sub.3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by fluorine, chlorine or bromine atoms, R.sub.4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, or R.sub.3 and R.sub.4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof. The compounds of general formula I above in which one of the groups R.sub.1 or R.sub.3 or both groups R.sub.1 and R.sub.3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.
Inventor(s):	Griss, deceased; Gerhart (late of Biberach, DE), Schneider; Claus (Ingelheim am Rhein, DE), Hurnaus; Rudolf (Biberach, DE), Kobinger; Walter (Vienna, AT), Pichler; Ludwig (Vienna, AT), Bauer; Rudolf (Wiesbaden, DE), Mierau; Joachim (Mainz, DE), Hinzen; Dieter (Zornheim, DE), Schingnitz; Gunter (Bad Kreuznach, DE)
Assignee:	Dr. Karl Thomae GmbH (Biberach an der Riss, DE)
Application Number:	07/256,671
Patent Claim Types: see list of patent claims	Compound; Use; Composition;

Drugs Protected by US Patent 4,886,812

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

Foreign Priority and PCT Information for Patent: 4,886,812

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
Germany	34470751	Dec 22, 1984
Germany	3508947	Mar 13, 1985

International Family Members for US Patent 4,886,812

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
European Patent Office	0186087		SPC/GB98/017	United Kingdom
European Patent Office	0186087		C980002	Netherlands
European Patent Office	0186087		98C0013	Belgium
Austria	45735
Australia	5154485
Australia	583874