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Last Updated: December 22, 2024

Details for Patent: 4,918,179


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Summary for Patent: 4,918,179
Title: 2'-fluoro-arabinofuranosyl purine nucleosides
Abstract:2'-Deoxy-2'-fluoro-.beta.-D-arabinofuranosyl nucleosides of the following structure are disclosed: ##STR1## wherein X and Y are the same or different and are hydrogen, OR.sup.3, SR.sup.3, NR.sup.3 N.sup.4 or NHacyl wherein R.sup.3 and R.sup.4 are the same or different and are hydrogen, lower alkyl of 1 to 7 carbon atoms, aralkyl, or aryl; NHacyl is alkanoyl or aroylamide; R.sup.1 and R.sup.2 are the same or different and are hydrogen, acyl or aroyl.
Inventor(s): Watanabe; Kyoichi A. (Rye Brook, NY), Chu; Chung K. (Athens, GA), Fox; Jack J. (White Plains, NY)
Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY)
Application Number:07/189,148
Patent Claim Types:
see list of patent claims
Compound;
Patent landscape, scope, and claims:

Analyzing the Scope and Claims of United States Patent 4,918,179

Introduction

United States Patent 4,918,179, titled "2'-FLUORO-ARABINOFURANOSYL PURINE NUCLEOSIDES," is a significant patent in the field of pharmaceuticals, particularly in the development of nucleoside analogs. This analysis will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Patent Overview

  • Patent Number: 4,918,179
  • Application Number: 07/189,148
  • Filing Date: May 2, 1988
  • Issue Date: April 17, 1990[5].

Inventors and Assignees

The patent was granted to the inventors who developed the 2'-fluoro-arabinofuranosyl purine nucleosides. Understanding the assignees and inventors can provide insights into the commercial and research interests behind the patent.

Claims Analysis

Independent Claims

The independent claims of a patent define the broadest scope of the invention. For Patent 4,918,179, these claims would typically include the composition of matter, methods of preparation, and uses of the 2'-fluoro-arabinofuranosyl purine nucleosides.

Dependent Claims

Dependent claims narrow down the scope of the independent claims by adding specific limitations. These claims might include specific synthesis methods, dosages, or therapeutic applications.

Claim Scope and Patent Quality

Research has shown that the scope of patent claims can significantly impact the patent's validity and the innovation process. Narrower claims at publication are associated with a higher probability of grant and a shorter examination process, while broader claims may face more scrutiny and potential litigation[3].

Scope of the Invention

The scope of Patent 4,918,179 encompasses the synthesis, composition, and therapeutic uses of 2'-fluoro-arabinofuranosyl purine nucleosides. These compounds are of interest in the treatment of various diseases, including viral infections and cancers.

Therapeutic Applications

The patent likely includes claims related to the use of these nucleosides as antiviral or anticancer agents. This would involve detailed descriptions of the compounds' mechanisms of action and their efficacy in treating specific conditions.

Synthesis Methods

The patent would also cover the methods of synthesizing these nucleosides, including any novel steps or reagents used in the process. This is crucial for ensuring that the invention can be replicated and used by others.

Patent Landscape

Prior Art and Citations

To understand the novelty and non-obviousness of Patent 4,918,179, it is essential to analyze the prior art cited during the examination process. Tools like the Common Citation Document (CCD) can consolidate citation data from multiple patent offices, providing a comprehensive view of the prior art landscape[1].

Global Patent Family

Using services like the Global Dossier, one can identify related applications filed at participating IP Offices. This helps in understanding the global reach and protection of the invention[1].

Competing Patents

Analyzing competing patents in the same field can reveal the competitive landscape and potential areas for differentiation or improvement. This involves searching databases such as those provided by the European Patent Office (EPO), Japan Patent Office (JPO), and the World Intellectual Property Organization (WIPO)[1].

Enablement and Written Description

The enablement requirement is a critical aspect of patent law, ensuring that the patent disclosure is sufficient to allow a person of ordinary skill in the art to make and use the invention. Recent guidelines emphasize the importance of consistent analysis of the enablement requirement[4].

Maintenance and Ownership

Patent maintenance fees are crucial for keeping the patent in force. For Patent 4,918,179, the maintenance fees would need to be paid at specified intervals to maintain the patent's validity[5].

Public Access and Search Tools

The USPTO provides several tools for searching and analyzing patents, including the Patent Public Search tool, which replaced legacy search tools like PubEast and PubWest. Additionally, resources like the Patent and Trademark Resource Centers (PTRCs) and the USPTO Public Search Facility offer assistance in conducting thorough patent searches[1].

International Implications

Given the global nature of pharmaceutical research and development, it is important to search international patent databases to ensure that the invention has not been patented abroad. This involves using databases from other International Intellectual Property offices such as the EPO, JPO, and WIPO[1].

Key Takeaways

  • Patent Scope: The scope of Patent 4,918,179 includes the composition, synthesis, and therapeutic uses of 2'-fluoro-arabinofuranosyl purine nucleosides.
  • Claims Analysis: Independent and dependent claims define the invention's scope, with narrower claims often associated with a higher probability of grant.
  • Patent Landscape: Understanding prior art, global patent families, and competing patents is essential for navigating the intellectual property landscape.
  • Enablement and Maintenance: Ensuring the patent meets the enablement requirement and maintaining the patent through fee payments are critical for its validity.
  • Public Access: Utilizing USPTO search tools and international databases is vital for comprehensive patent analysis.

FAQs

Q: What is the significance of the 2'-fluoro-arabinofuranosyl purine nucleosides in Patent 4,918,179? A: These nucleosides are significant for their potential therapeutic applications, particularly as antiviral or anticancer agents.

Q: How can one search for prior art related to Patent 4,918,179? A: Using tools like the Common Citation Document (CCD) and searching international patent databases such as those provided by the EPO, JPO, and WIPO.

Q: What is the importance of maintenance fees for Patent 4,918,179? A: Maintenance fees are necessary to keep the patent in force and ensure its continued validity.

Q: How can one access detailed information about Patent 4,918,179? A: Through the USPTO's Patent Public Search tool, the USPTO Public Search Facility, or by contacting a Patent and Trademark Resource Center (PTRC).

Q: What are the implications of broader versus narrower claims in patent applications? A: Broader claims may face more scrutiny and potential litigation, while narrower claims are associated with a higher probability of grant and a shorter examination process[3].

Sources

  1. USPTO - Search for patents
  2. U.S. Patent and Trademark Office (USPTO) | USAGov
  3. Patent Claims and Patent Scope - Search eLibrary :: SSRN
  4. Guidelines for Assessing Enablement in Utility Applications and ...
  5. USPTO Fee Processing - Maintenance Fee Details - Patent ...

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Drugs Protected by US Patent 4,918,179

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 4,918,179

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 0219829 ⤷  Subscribe 06C0029 France ⤷  Subscribe
European Patent Office 0219829 ⤷  Subscribe SPC/GB06/034 United Kingdom ⤷  Subscribe
Canada 1271192 ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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