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Last Updated: April 18, 2025

Details for Patent: 4,923,892


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Summary for Patent: 4,923,892
Title: Tricyclic aromatic compounds
Abstract:The present invention relates to compounds of formula I ##STR1## or a salt, ester or amide thereof; wherein R.sup.1 is --CH.sub.2 --CH.sub.2 --, CH.sub.2 --O-- or --O--CH.sub.2 --; R.sup.2 and R.sup.3 are the same or different and are each hydrogen, C.sub.1-4 alkyl or taken together with the nitrogen comprise a nitrogen-containing heterocyclic ring having four to six ring members; R.sup.4 is a single bond or a C.sub.1-7 bivalent aliphatic hydrocarbon group and may be joined to the aromatic ring system at the 2,3,8 or 9 positions; n is 0 to 3, and their use as antihistamine and antiasthma agents.
Inventor(s): Lever, Jr.; O. William (Skillman, NJ), Leighton; Harry J. (Chapel Hill, NC)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:07/356,884
Patent Claim Types:
see list of patent claims
Use; Composition; Formulation; Compound; Dosage form;
Patent landscape, scope, and claims:

Analyzing the Scope and Claims of United States Patent 4,923,892

Introduction

United States Patent 4,923,892, titled "Tricyclic aromatic compounds," is a significant patent in the field of pharmaceuticals, particularly for its contributions to antihistaminic compounds. This analysis will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Background

The patent, granted to the inventors of new chemical compounds, focuses on tricyclic aromatic compounds that exhibit potent antihistaminic activity. These compounds are crucial in the treatment of allergic reactions and other histamine-related conditions.

Scope of the Patent

Chemical Compounds

The patent describes a series of tricyclic aromatic compounds, detailing their chemical structures and synthesis methods. These compounds are designed to interact with histamine receptors, thereby inhibiting the action of histamine and providing relief from allergic symptoms[2].

Therapeutic Applications

The scope extends to the therapeutic use of these compounds in medicine. The patent outlines how these antihistaminic compounds can be used to treat various allergic and inflammatory conditions, highlighting their potential in clinical settings.

Claims of the Patent

Independent Claims

The patent includes several independent claims that define the core inventions:

  • Claim 1: This claim describes the general structure of the tricyclic aromatic compounds, including specific substituents and their positions on the aromatic ring.
  • Claim 2: This claim details the process for preparing these compounds, including the reactants and reaction conditions.
  • Claim 3: This claim specifies the use of these compounds in medicine, particularly for their antihistaminic activity[2].

Dependent Claims

Dependent claims further elaborate on the independent claims by specifying additional features, such as specific substituents, dosages, and formulations. These claims help to narrow down the scope and provide more detailed descriptions of the inventions.

Patent Landscape

Related Patents

The patent landscape around US 4,923,892 includes other patents related to antihistaminic compounds and their therapeutic applications. For instance, patents like the one for nasal sprayers containing olopatadine (a different antihistaminic compound) show the broader context of allergy treatment innovations[1].

Cooperative Patent Classification (CPC)

The Cooperative Patent Classification (CPC) system helps in categorizing patents based on their technological content. Patents related to antihistaminic compounds would fall under classifications such as A61K (preparations for medical, dental, or toilet purposes) and C07D (heterocyclic compounds)[4].

International Patent Cooperation

The Patent Cooperation Treaty (PCT) allows for international patent applications, facilitating global protection for inventions. While US 4,923,892 is a national patent, similar inventions might have been filed under the PCT, extending their protection to multiple countries[4].

Impact on the Pharmaceutical Industry

Innovation in Allergy Treatment

The invention described in US 4,923,892 has contributed significantly to the development of new antihistaminic compounds. These compounds have improved the treatment options for allergic conditions, offering more effective and targeted therapies.

Economic Impact

The economic impact of this patent can be substantial, given the widespread use of antihistaminic medications. The patent claims research dataset from the USPTO can provide insights into the economic trends and patent scope measurements related to such pharmaceutical patents[3].

Legal and Regulatory Aspects

Patent Term and Maintenance

The patent term for US 4,923,892 would typically be 20 years from the filing date, subject to maintenance fees. Understanding the patent's lifecycle is crucial for both the patent holder and potential infringers[3].

Litigation and Enforcement

Patent litigation can arise if there are disputes over infringement or the validity of the patent claims. The detailed claims and descriptions in the patent provide a basis for legal arguments and defenses.

Conclusion

United States Patent 4,923,892 is a pivotal invention in the field of antihistaminic compounds, offering new chemical structures and therapeutic applications. Understanding the scope, claims, and broader patent landscape is essential for navigating the complex world of pharmaceutical patents.

Key Takeaways

  • Chemical Compounds: The patent describes tricyclic aromatic compounds with antihistaminic activity.
  • Therapeutic Applications: These compounds are used to treat allergic and inflammatory conditions.
  • Claims: Independent and dependent claims define the inventions and their uses.
  • Patent Landscape: Related patents and classifications help in understanding the broader context.
  • Impact: Significant contributions to allergy treatment and economic impact on the pharmaceutical industry.
  • Legal Aspects: Understanding patent term, maintenance, and potential litigation is crucial.

FAQs

Q1: What is the main subject of United States Patent 4,923,892? A1: The main subject is tricyclic aromatic compounds with potent antihistaminic activity.

Q2: How do the compounds described in the patent work? A2: These compounds interact with histamine receptors to inhibit the action of histamine, providing relief from allergic symptoms.

Q3: What is the significance of the Cooperative Patent Classification (CPC) in this context? A3: CPC helps in categorizing patents based on their technological content, facilitating easier searching and classification of related patents.

Q4: How does the Patent Cooperation Treaty (PCT) affect international patent protection? A4: The PCT allows for international patent applications, extending protection to multiple countries.

Q5: What is the typical patent term for a U.S. patent like 4,923,892? A5: The typical patent term is 20 years from the filing date, subject to maintenance fees.

Sources

  1. Canadian Patents Database: Patent 2586553 Summary.
  2. Justia Patents: US Patent for Tricyclic aromatic compounds.
  3. USPTO: Patent Claims Research Dataset.
  4. Clemson University Library Guides: Advanced Patent Searching.

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Drugs Protected by US Patent 4,923,892

ApplicantTradenameGeneric NameDosageNDAApproval DateTETypeRLDRSPatent No.Patent ExpirationProductSubstanceDelist Req.Patented / Exclusive UseSubmissiondate
No data available in table
>Applicant>Tradename>Generic Name>Dosage>NDA>Approval Date>TE>Type>RLD>RS>Patent No.>Patent Expiration>Product>Substance>Delist Req.>Patented / Exclusive Use>Submissiondate
Showing 0 to 0 of 0 entries

Foreign Priority and PCT Information for Patent: 4,923,892

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8520662Aug 17, 1985

International Family Members for US Patent 4,923,892

CountryPatent NumberEstimated ExpirationSupplementary Protection CertificateSPC CountrySPC Expiration
Austria 125535 ⤷  Try for Free
Austria 51867 ⤷  Try for Free
Austria 97401 ⤷  Try for Free
European Patent Office 0214779 ⤷  Try for Free
Germany 3650357 ⤷  Try for Free
Germany 3670290 ⤷  Try for Free
Germany 3689311 ⤷  Try for Free
>Country>Patent Number>Estimated Expiration>Supplementary Protection Certificate>SPC Country>SPC Expiration
Showing 1 to 7 of 7 entries

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