Details for Patent: 4,933,361

Summary for Patent: 4,933,361

Title:	Derivatives of bicyclic aminoacids agents containing these compounds and their use
Abstract:	Disclosed are cis, exo- and trans-compounds of the formula I ##STR1## in which n denotes 0, 1 or 2, R.sub.1 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl which can optionally be substituted by amino, (C.sub.1 -C.sub.4)-acyl- or bezoylamino, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.9)-cycloalkyl, (C.sub.5 -C.sub.9)-cycloalkenyl, (C.sub.5 -C.sub.7)-cycloalkyl-(C.sub.1 -C.sub.4)-alkyl, aryl or partially hydrogenated aryl, which can, in each case, be substituted by (C.sub.1 -C.sub.2)-alkyl, (C.sub.1 -C.sub.2)-alkoxy or halogen, aryl-(C.sub.1 -C.sub.4)-alkyl, /which can be substituted as defined previously in the aryl radical/, a monocyclic or bicyclic sulfur or nitrogen and/or nitrogen heterocyclic radical, or a side chain of naturally occurring aminoacid, R.sub.2 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl or aryl-(C.sub.1 -C.sub.4)-alkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen, X denotes (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.6 -C.sub.9)-cycloalkyl or aryl which can be mono-, di- or tri- substituted by (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy, hydroxyl, halogen, nitro, amino, (C.sub.1 -C.sub.4)-alkylamino, di-(C.sub.1 -C.sub.4 -alkylamino or methylenedioxy, or indol-3-yl, or physiologically acceptable salts thereof, a process of the preparation thereof, agents containing them, their use as a medicine and intermediates for the preparation thereof.
Inventor(s):	Urbach; Hansjorg (Kronberg/Tannus, DE), Henning; Rainer (Frankfurt am Main, DE), Teetz; Volker (Hofheim am Taunus, DE), Geiger; Rolf (Frankfurt am Main, DE), Becker; Reinhard (Wiesbaden, DE), Gaul; Holger (Niederneisen, DE)
Assignee:	Hoechst Aktiengesellschaft (Framkfurt am Main, DE)
Application Number:	07/346,339
Patent Claim Types: see list of patent claims	Compound; Use; Composition;

Detailed Analysis of the Scope and Claims of United States Patent 4,933,361

Introduction to Patent 4,933,361

United States Patent 4,933,361, titled "Derivatives of bicyclic aminoacids agents containing these compounds and their use," was granted on June 12, 1990. This patent is significant in the field of organic chemistry and pharmaceuticals, particularly in the development of compounds with therapeutic applications.

Scope of the Patent

Technology Domain

The patent falls within the domain of organic chemistry, specifically focusing on the synthesis and use of derivatives of bicyclic amino acids. These compounds are designed for therapeutic applications, including treatments for disorders related to the blood, cardiovascular system, and other medical conditions[4].

Key Compounds

The patent describes compounds of specific formulas, such as formula III, where n represents a whole number from 0 to 10, and W' represents hydrogen, alkyl, or aralkyl groups. These compounds serve as starting materials for the synthesis of other therapeutic agents[4].

Claims of the Patent

Main Claims

The patent includes several claims that outline the scope of the invention:

• Compound Structure: The patent claims compounds of the formula III, with specific configurations and substitutions.
• Synthesis Methods: It describes various procedures for preparing these compounds, including hydrogenolysis and acid-mediated reactions.
• Therapeutic Use: The claims also cover the use of these compounds as therapeutic agents, particularly for disorders of the blood and cardiovascular system[4].

Specific Claims

• Claim 1: This claim specifies the general structure of the compounds, including the bicyclic amino acid derivatives.
• Claim 2-6: These claims detail specific substitutions and configurations of the compounds, as well as their therapeutic applications.

Patent Landscape Analysis

Defining Scope and Keywords

To analyze the patent landscape around US 4,933,361, one must define the scope and identify relevant keywords. Key terms include "bicyclic amino acids," "therapeutic agents," "cardiovascular disorders," and "blood disorders"[3].

Search and Organize Patents

Using databases such as the USPTO's Patent Public Search tool, one can find relevant patents based on these keywords. Organizing these patents by factors like filing date, assignee, and technology subcategories helps in understanding the evolution of the technology[1].

Identify Trends and Key Players

The analysis reveals trends in patent filings related to bicyclic amino acid derivatives. Key players in this field include pharmaceutical companies and research institutions that have been actively filing patents in this domain. For example, the patent in question was assigned to a pharmaceutical company, indicating the commercial interest in these compounds[3].

Analyze Citations and Evolution

Studying how patents reference each other provides insights into the impact and development of the technology. The patent 4,933,361 is cited by later patents, such as US 7,157,484 B2, indicating its influence on subsequent research and development in the field[2][5].

Generate Insights for Decisions

The analysis offers practical guidance for strategic decisions. It helps in evaluating the competitive landscape, identifying potential legal vulnerabilities, and understanding the strength of the patent portfolio. For instance, the expiration of the patent (lifetime expired) means that the technology is now in the public domain, which can influence business strategies related to the use and development of these compounds[3].

Insights from the Patent Landscape Analysis

Technological Trends

The analysis shows a trend towards the development of more specific and targeted therapeutic agents. The use of bicyclic amino acid derivatives has been a focus area in pharmaceutical research, indicating ongoing innovations in this domain.

Key Players

Pharmaceutical companies and research institutions are the primary players in this field. Understanding their patent portfolios and strategies can provide valuable insights into the competitive landscape.

Legal and Strategic Implications

The expiration of the patent means that the technology is no longer protected, allowing other companies to develop and use similar compounds. This can lead to increased competition and innovation in the field.

Competitive Landscape

The competitive landscape in the field of bicyclic amino acid derivatives is dynamic. With the patent having expired, other companies can now develop similar compounds, leading to potential new entrants in the market. This competition can drive innovation and reduce costs for therapeutic agents.

Future Directions

Given the insights from the patent landscape analysis, future directions could include:

• Further Research and Development: Continuing to develop more targeted and effective therapeutic agents based on bicyclic amino acid derivatives.
• Market Expansion: With the technology now in the public domain, companies can expand their product lines to include these compounds, potentially entering new markets.
• Collaborations and Licensing: Companies may seek collaborations or licensing agreements to leverage the existing knowledge and technology in this field.

Key Takeaways

• Patent Scope: The patent covers specific compounds and their therapeutic uses, particularly in cardiovascular and blood disorders.
• Claims: The claims detail the structure, synthesis, and use of these compounds.
• Patent Landscape: The analysis reveals trends, key players, and the impact of the patent on subsequent research.
• Competitive Landscape: The expiration of the patent opens up opportunities for new entrants and increased competition.
• Future Directions: Continued R&D, market expansion, and collaborations are potential future directions.

FAQs

What is the main focus of United States Patent 4,933,361?

The main focus of the patent is on the synthesis and therapeutic use of derivatives of bicyclic amino acids.

What are the therapeutic applications of the compounds described in the patent?

The compounds are designed for treating disorders related to the blood and cardiovascular system.

Who are the key players in the field of bicyclic amino acid derivatives?

Key players include pharmaceutical companies and research institutions that have been actively filing patents in this domain.

What is the current legal status of the patent?

The patent has expired, meaning the technology is now in the public domain.

How does the expiration of the patent affect the competitive landscape?

The expiration allows other companies to develop and use similar compounds, leading to increased competition and potential innovation in the field.

Sources

1. USPTO - Search for patents: https://www.uspto.gov/patents/search
2. Google Patents - US7157484: https://patentimages.storage.googleapis.com/c5/9d/6d/c168cc740ff67b/US7157484.pdf
3. Goldstein Patent Law - How to Do Patent Landscape Analysis: https://www.goldsteinpatentlaw.com/how-to-patent-landscape-analysis/
4. Google Patents - US4933361A: https://patents.google.com/patent/US4933361A/en
5. Unified Patents - US-7157485-B2: https://portal.unifiedpatents.com/patents/patent/US-7157485-B2

Drugs Protected by US Patent 4,933,361

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

Foreign Priority and PCT Information for Patent: 4,933,361

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
Germany	3151690	Dec 29, 1981
Germany	3210701	Mar 24, 1982

International Family Members for US Patent 4,933,361

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
European Patent Office	0084164		SPC/GB93/146	United Kingdom
Argentina	247571
Austria	25244
Austria	47838
Australia	559140
Australia	9193182