Details for Patent: 5,288,726
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Summary for Patent: 5,288,726
| Title: | Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs thereof and their preparation and uses for inhibiting blood platelet aggregation |
| Abstract: | Compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkanoyl, haloalkanoyl, carboxy, alkoxycarbonyl, carbamoyl, cyano, nitro, alkanesulfonyl, haloalkanesulfonyl or sulfamoyl; R.sup.2 is optionally substituted alkanoyl, optionally substituted alkenoyl, optionally substituted cycloalkylcarbonyl, substituted benzoyl, or 5,6-dihydro-1,4,2-dioxazin-3-yl; R.sup.3 is hydrogen, hydroxy, optionally substituted alkoxy, aralkyloxy, alkanoyloxy, alkenoyloxy, cycloalkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aralkyloxycarbonylxy, phthalidyloxy, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methoxy, optionally substituted amino or nitro; Y is --NH-- or oxygen or sulfur; n is 1 to 5; and tautomers and salts of said compounds of formula (I), have the ability to inhibit blood platelet aggregation, and can thus be used for treatment and prophylaxis of thrombosis and embolisms. |
| Inventor(s): | Koike; Hiroyuki (Tokyo, JP), Asai; Fumitoshi (Tokyo, JP), Sugidachi; Atsuhiro (Tokyo, JP), Kimura; Tomio (Ube, JP), Inoue; Teruhiko (Ube, JP), Nishino; Shigeyoshi (Ube, JP), Tsuzaki; Yasunori (Ube, JP) |
| Assignee: | Ube Industries Limited (Ube, JP) Sankyo Company, Limited (Tokyo, JP) |
| Application Number: | 07/941,676 |
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Patent Claim Types: see list of patent claims | Compound; Use; Composition; |
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Drugs Protected by US Patent 5,288,726
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
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| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 5,288,726
International Family Members for US Patent 5,288,726
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
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| European Patent Office | 0542411 | ⤷ Subscribe | CA 2009 00024 | Denmark | ⤷ Subscribe |
| European Patent Office | 0542411 | ⤷ Subscribe | 91589 | Luxembourg | ⤷ Subscribe |
| European Patent Office | 0542411 | ⤷ Subscribe | 300397 | Netherlands | ⤷ Subscribe |
| European Patent Office | 0542411 | ⤷ Subscribe | SPC021/2009 | Ireland | ⤷ Subscribe |
| European Patent Office | 0542411 | ⤷ Subscribe | 09C0031 | France | ⤷ Subscribe |
| European Patent Office | 0542411 | ⤷ Subscribe | SPC/GB09/032 | United Kingdom | ⤷ Subscribe |
| European Patent Office | 0542411 | ⤷ Subscribe | C00542411/01 | Switzerland | ⤷ Subscribe |
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