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Last Updated: December 22, 2024

Details for Patent: 5,298,520


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Summary for Patent: 5,298,520
Title: Triazole containing indole derivatives
Abstract:A class of substituted imidazole, triazole and tetrazole derivatives are selective agonists of 5-HT.sub.1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.
Inventor(s): Baker; Raymond (Much Hadham, GB2), Matassa; Victor G. (Furneux Pelham, GB2), Street; Leslie J. (Harlow, GB2)
Assignee: Merck Sharp & Dohme Limited (Hertfordshire, GB2)
Application Number:07/827,187
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;
Patent landscape, scope, and claims:

United States Patent 5,298,520: A Detailed Analysis of Scope, Claims, and Patent Landscape

Introduction

United States Patent 5,298,520, titled "Triazole containing indole derivatives," is a patent that has significant implications in the field of pharmaceuticals, particularly in the treatment of migraines and other related conditions. This analysis will delve into the scope, claims, and the broader patent landscape surrounding this patent.

Patent Overview

Publication and Status

The patent, US 5,298,520, was published on March 29, 1994, and has since expired. The legal status indicates that the patent is no longer in force, meaning that the exclusive rights granted to the patent holder have lapsed[4].

Inventors and Assignees

While the specific inventors and assignees are not detailed here, it is common for such patents to be assigned to pharmaceutical companies or research institutions that have developed the compounds.

Scope of the Patent

Subject Matter

The patent pertains to triazole containing indole derivatives, which are chemical compounds with potential therapeutic applications. Specifically, these compounds are described as having antipsychotic and anti-migraine properties[4].

Claims

The patent includes multiple claims that define the scope of the invention. These claims typically cover the chemical structures of the compounds, methods of preparation, and their use in treating specific diseases. For example:

  • Chemical Compounds: The patent claims various triazole containing indole derivatives, including their salts and other chemical forms.
  • Methods of Preparation: The claims include detailed methods for synthesizing these compounds.
  • Therapeutic Uses: The patent specifies the use of these compounds in treating migraines and other related conditions[4].

Claim Analysis

Independent and Dependent Claims

The patent includes both independent and dependent claims. Independent claims stand alone and define the invention broadly, while dependent claims build upon the independent claims and provide more specific details.

Claim Scope and Breadth

The scope of the claims is crucial in determining the patent's coverage. For US 5,298,520, the claims are broad enough to cover a range of triazole containing indole derivatives but specific enough to ensure that the invention is clearly defined and distinguishable from prior art.

Patent Landscape

Prior Art and Novelty

The patent landscape for US 5,298,520 involves an analysis of prior art to ensure that the claimed invention is novel and non-obvious. The patent cites various prior art keywords, such as indoles, triazoles, and methods of preparation, indicating that the inventors have built upon existing knowledge in the field[4].

Related Patents and Applications

The patent is part of a larger family of patents related to indole derivatives and their therapeutic applications. Tools like the USPTO's Patent Public Search and Global Dossier can be used to identify related patents and applications, providing a comprehensive view of the patent landscape[1].

Legal and Regulatory Aspects

Patent Term and Expiration

The patent term for US 5,298,520 has expired, which means that the exclusive rights to make, use, and sell the invention are no longer in force. This allows other entities to use the disclosed information without infringing on the original patent[4].

Reissue and Continuation Applications

In cases where a patent holder seeks to modify the scope of their claims after the patent has been granted, they may file reissue or continuation applications. However, these applications are subject to strict statutory limitations, such as the "original patent" requirement under 35 U.S.C. § 251, which ensures that the reissue claims are directed to the invention disclosed in the original patent[2].

Economic and Market Impact

Pharmaceutical Market

The expiration of US 5,298,520 allows generic versions of the drug to enter the market, potentially reducing costs and increasing accessibility for patients. This can significantly impact the pharmaceutical market, especially for drugs like Maxalt, which is mentioned in related documents as a human drug product claiming similar compounds[5].

Research and Development

The disclosure of the patent's details can also stimulate further research and development in the field of indole derivatives. Researchers can build upon the existing knowledge to develop new compounds or improve existing ones, contributing to the advancement of therapeutic treatments.

Conclusion

United States Patent 5,298,520 is a significant patent in the pharmaceutical sector, particularly for the treatment of migraines and related conditions. Understanding the scope, claims, and patent landscape of this patent is crucial for both legal and strategic purposes.

Key Takeaways

  • Patent Scope: The patent covers triazole containing indole derivatives, including their chemical structures, methods of preparation, and therapeutic uses.
  • Claims Analysis: The patent includes independent and dependent claims that define the invention broadly and specifically.
  • Patent Landscape: The patent is part of a larger family of patents related to indole derivatives and is subject to prior art and novelty requirements.
  • Legal and Regulatory Aspects: The patent term has expired, allowing for generic versions and further research.
  • Economic and Market Impact: The expiration affects the pharmaceutical market by allowing generic versions and stimulating further research.

FAQs

What is the main subject matter of US Patent 5,298,520?

The main subject matter of US Patent 5,298,520 is triazole containing indole derivatives, which are chemical compounds with potential therapeutic applications.

What are the therapeutic uses of the compounds described in the patent?

The compounds are described as having antipsychotic and anti-migraine properties.

Is the patent still in force?

No, the patent has expired, meaning the exclusive rights to make, use, and sell the invention are no longer in force.

How can one find related patents and applications?

Tools like the USPTO's Patent Public Search and Global Dossier can be used to identify related patents and applications.

What impact does the expiration of the patent have on the pharmaceutical market?

The expiration allows generic versions of the drug to enter the market, potentially reducing costs and increasing accessibility for patients.

Can the patent holder modify the scope of their claims after the patent has been granted?

Yes, but any modifications are subject to strict statutory limitations, such as the "original patent" requirement under 35 U.S.C. § 251[2].

Sources

  1. USPTO - Search for Patents: https://www.uspto.gov/patents/search
  2. Court of Appeals for the Federal Circuit - In Re FLOAT'N'GRILL LLC: https://cafc.uscourts.gov/opinions-orders/22-1438.OPINION.7-12-2023_2156183.pdf
  3. USPTO - Patent Claims Research Dataset: https://www.uspto.gov/ip-policy/economic-research/research-datasets/patent-claims-research-dataset
  4. Google Patents - US5298520A: https://patents.google.com/patent/US5298520A/es
  5. USPTO - Patent Term Extension Application: https://www.uspto.gov/web/offices/com/sol/foia/tac/pte/5298520.pdf

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Drugs Protected by US Patent 5,298,520

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 5,298,520

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9102222Feb 01, 1991
United Kingdom9106917Apr 03, 1991
United Kingdom9113415Jun 21, 1991
United Kingdom9122451Oct 23, 1991

International Family Members for US Patent 5,298,520

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 0497512 ⤷  Subscribe 98C0037 France ⤷  Subscribe
European Patent Office 0497512 ⤷  Subscribe C980019 Netherlands ⤷  Subscribe
European Patent Office 0497512 ⤷  Subscribe SPC/GB98/035 United Kingdom ⤷  Subscribe
European Patent Office 0497512 ⤷  Subscribe 9891028-4 Sweden ⤷  Subscribe
European Patent Office 0497512 ⤷  Subscribe 99C0011 Belgium ⤷  Subscribe
European Patent Office 0497512 ⤷  Subscribe 28/1998 Austria ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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