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Last Updated: December 22, 2024

Details for Patent: 5,457,105


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Summary for Patent: 5,457,105
Patent landscape, scope, and claims:
Title: Quinazoline derivatives useful for treatment of neoplastic disease
Abstract:The invention concerns quinazoline derivatives of the formula I ##STR1## wherein m is 1, 2 or 3 and each R.sup.1 includes hydroxy, amino, carboxy, carbamoyl, ureido, (1-4C)alkoxycarbonyl, N-(1-4C)alkylcarbamoyl, N,N-di-[(1-4C)alkyl]carbamoyl, hydroxyamino, (1-4C)alkoxyamino, (2-4C)alkanoyloxyamino, trifluoromethoxy, (1-4C)alkyl, (1-4C)alkoxy and (1-3C)alkylenedioxy; n is 1 or 2 and each R.sup.2 includes hydrogen, hydroxy, halogeno, trifluoromethyl, amino, nitro, cyano and (1-4C)alkyl; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cancer.
Inventor(s): Barker; Andrew J. (Macclesfield, GB2)
Assignee: Zeneca Limited (London, GB2)
Application Number:08/284,293
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

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Drugs Protected by US Patent 5,457,105

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 5,457,105

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9201095Jan 20, 1992
United Kingdom9213572Jun 26, 1992
United Kingdom9223735Nov 12, 1992

International Family Members for US Patent 5,457,105

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 130000 ⤷  Subscribe
Australia 3101093 ⤷  Subscribe
Australia 661533 ⤷  Subscribe
Canada 2086968 ⤷  Subscribe
Czech Republic 282038 ⤷  Subscribe
Czech Republic 9300043 ⤷  Subscribe
Germany 69300754 ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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