Details for Patent: 5,500,413
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Summary for Patent: 5,500,413
Title: | Process for manufacture of 1-deamino-8-D-arginine vasopressin |
Abstract: | A process for the manufacture of 1-deamino-8-D-arginine vasopressin (DDAVP) comprising, condensing a preparation of Mpa(R.sup.1)-Tyr-Phe-Gln-Asn-Cys(R.sup.2)-Pro-OH (SEQ ID NO: 1), where R.sup.1 and R.sup.2 are sulfhydryl-protecting groups, with the dipeptide (R.sup.3)-D-Arg(HCl)-Gly-NH.sub.2, where R.sup.3 is an acid-sensitive amino-protecting group, to form Mpa(R.sup.1)-Tyr-Phe-Gln-Asn-Cys(R.sup.2)-Pro-D-Arg(HCl)-Gly-NH.sub.2 (SEQ ID NO: 1), which is oxidized with iodine in a protic solvent. The reaction mixture containing the oxidized product can be purified by ion exchange chromatography on a cation exchange resin equilibrated with acid. Also disclosed is high-purity DDAVP obtained by this process and its use for treating diurea. |
Inventor(s): | Larsson; Krister (Malmo, SE), Mellbrand; Thomas (Malmo, SE), Mornstam; Birgitta (Malmo, SE), Roschester; Jan (Lund, SE), Skoldback; Jan-Ake (Malmo, SE) |
Assignee: | Ferring AB (Malmo, SE) |
Application Number: | 08/084,847 |
Patent Claim Types: see list of patent claims | Use; Compound; |
Drugs Protected by US Patent 5,500,413
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