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Last Updated: April 22, 2025

Details for Patent: 5,538,982


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Summary for Patent: 5,538,982
Title: Medical use for tachykinin antagonists
Abstract:The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharmaceutical compositions containing them and their medical use. ##STR1## wherein R represents the ring A ##STR2## or 2-pyridinyl or 2-pyridinyl-N-oxide; R.sup.1 is selected from halogen atoms and C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, and S(O).sub.n C.sub.1-4 alkyl groups; R.sup.2 and R.sup.3, which may be the same or different, each independently are selected from hydrogen and halogen atoms and C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl and cyano groups; n represents zero, 1 or 2; and pharmaceutically acceptable salts and solvates thereof.
Inventor(s): Hagan; Russell M. (Ware, GB), Bunce; Keith T. (Ware, GB)
Assignee: Glaxo Group Limited (London, GB2)
Application Number:08/269,079
Patent Claim Types:
see list of patent claims
Use; Compound;
Patent landscape, scope, and claims:

Analyzing the Scope and Claims of United States Patent 5,538,982: A Comprehensive Guide

Introduction

United States Patent 5,538,982, titled "Medical use for tachykinin antagonists," is a significant patent that has contributed to the field of medical research, particularly in the treatment of various conditions using tachykinin antagonists. This article will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Background of the Patent

Publication and Legal Status

The patent, US5538982A, was published on August 20, 1996, and has since expired due to the completion of its lifetime[2].

Inventors and Assignees

While the specific inventors and assignees are not detailed in the provided sources, it is common for such patents to be assigned to pharmaceutical companies or research institutions involved in the development of the compounds.

Scope of the Patent

Medical Applications

The patent focuses on the medical use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists. These compounds are particularly useful in treating a range of conditions such as:

  • Emesis: Tachykinin antagonists acting at NK 1 receptors have been found effective in treating emesis, which includes nausea and vomiting[2].
  • Visceral Pain: Conditions like myocardial infarction or peritonitis.
  • Migraine and Increased Intracranial Pressure: Including altitude sickness.
  • Gastrointestinal Disorders: Such as gastrointestinal obstruction and reduced gastrointestinal motility.
  • Vestibular Disorders: Including motion sickness and post-operative sickness[2].

Chemical Compounds

The patent specifies various chemical compounds and their structures, including those disclosed in other patent specifications like EP 0360390 and WO 92/01688. These compounds are characterized by specific formulas and structural elements, such as the presence of alkyl groups, phenyl rings, and other functional groups[2].

Claims of the Patent

Independent and Dependent Claims

The patent includes both independent and dependent claims. Independent claims define the broad scope of the invention, while dependent claims narrow down the scope by adding additional limitations.

Key Claims

  • Claim 1: Typically, the first claim is the broadest and defines the core invention. For US5538982A, this would involve the use of tachykinin antagonists for treating specific medical conditions.
  • Dependent Claims: These claims build upon the independent claims by specifying particular compounds, dosages, and methods of administration[2].

Patent Landscape

Global Patent System

The patent is part of a larger global patent system. Tools like the Global Dossier and Common Citation Document (CCD) facilitate the integration of patent information across different intellectual property offices. This allows for a more comprehensive view of related patent applications and prior art[1].

International Search Resources

To understand the broader patent landscape, one can refer to international patent databases such as those provided by the European Patent Office (EPO), Japan Patent Office (JPO), and the World Intellectual Property Organization (WIPO). These resources help in identifying similar patents and prior art globally[1].

Patent Assignment and Ownership

The Patent Assignment Search tool provided by the USPTO allows users to track changes in ownership of patents, which can be crucial for understanding the current status and potential licensing opportunities of a patent like US5538982A[1].

Economic and Research Implications

Patent Claims Research Dataset

The USPTO's Patent Claims Research Dataset provides detailed information on claims from US patents, including those related to medical inventions. This dataset can be used to analyze trends and scope measurements of patents, offering insights into the economic and research implications of inventions like US5538982A[3].

Impact on Innovation

Patents like US5538982A drive innovation by protecting intellectual property and encouraging further research and development. The mission of the USPTO, to drive U.S. innovation and global competitiveness, is exemplified through such patents[4].

Practical Applications and Future Directions

Clinical Use

The compounds described in the patent have been clinically used to treat various conditions. For instance, tachykinin antagonists have shown promise in reducing nausea and vomiting associated with chemotherapy and other medical treatments.

Future Research

The expiration of the patent opens up opportunities for generic versions of these compounds and further research into their applications. New studies could explore additional medical uses or improvements in the existing treatments.

Key Takeaways

  • Medical Use: US5538982A focuses on the medical use of tachykinin antagonists for treating conditions like emesis, visceral pain, and gastrointestinal disorders.
  • Chemical Compounds: The patent details specific chemical structures and formulas of the compounds.
  • Global Patent Landscape: Tools like Global Dossier and CCD help integrate patent information globally.
  • Economic Implications: The patent contributes to innovation and economic growth by protecting intellectual property.
  • Future Directions: The expiration of the patent allows for further research and the development of generic versions.

FAQs

What is the primary focus of United States Patent 5,538,982?

The primary focus of US5538982A is the medical use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, for treating various medical conditions.

What are some of the medical conditions treated by the compounds described in the patent?

The compounds are used to treat conditions such as emesis, visceral pain, migraine, gastrointestinal disorders, and vestibular disorders.

How can one search for related patents globally?

One can use resources like the Global Dossier, Common Citation Document (CCD), and international patent databases provided by offices like the EPO, JPO, and WIPO.

What is the significance of the Patent Assignment Search tool?

The Patent Assignment Search tool helps track changes in ownership of patents, which is crucial for understanding the current status and potential licensing opportunities.

What dataset can be used to analyze trends and scope measurements of patents like US5538982A?

The USPTO's Patent Claims Research Dataset provides detailed information on claims from US patents and can be used to analyze trends and scope measurements.

Sources

  1. USPTO - Search for patents: https://www.uspto.gov/patents/search
  2. Google Patents - US5538982A: https://patents.google.com/patent/US5538982A/en
  3. USPTO - Patent Claims Research Dataset: https://www.uspto.gov/ip-policy/economic-research/research-datasets/patent-claims-research-dataset
  4. U.S. Department of Commerce - U.S. Patent and Trademark Office: https://www.commerce.gov/bureaus-and-offices/uspto

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Drugs Protected by US Patent 5,538,982

ApplicantTradenameGeneric NameDosageNDAApproval DateTETypeRLDRSPatent No.Patent ExpirationProductSubstanceDelist Req.Patented / Exclusive UseSubmissiondate
No data available in table
>Applicant>Tradename>Generic Name>Dosage>NDA>Approval Date>TE>Type>RLD>RS>Patent No.>Patent Expiration>Product>Substance>Delist Req.>Patented / Exclusive Use>Submissiondate
Showing 0 to 0 of 0 entries

Foreign Priority and PCT Information for Patent: 5,538,982

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9120172Sep 20, 1991
United Kingdom9202839Feb 11, 1992
United Kingdom9204151Feb 27, 1992

International Family Members for US Patent 5,538,982

CountryPatent NumberEstimated ExpirationSupplementary Protection CertificateSPC CountrySPC Expiration
Australia 2458392 ⤷  Try for Free
Australia 657996 ⤷  Try for Free
Austria 195867 ⤷  Try for Free
Canada 2078578 ⤷  Try for Free
Denmark 0533280 ⤷  Try for Free
Germany 69231395 ⤷  Try for Free
>Country>Patent Number>Estimated Expiration>Supplementary Protection Certificate>SPC Country>SPC Expiration
Showing 1 to 6 of 6 entries

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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.