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Last Updated: December 22, 2024

Details for Patent: 5,688,801


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Summary for Patent: 5,688,801
Title: Method of inhibiting neurotransmitter activity using microencapsulated 3-piperidiny2-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
Abstract:A pharmaceutical composition comprising a biodegradable and biocompatible composition comprising a 1,2 benzazole within a polymeric matrix. The 1,2 benzazole composition, pharmaceutically acceptable acid addition salts thereof, are potent antagonists of a series of neurotransmitters, particularly serotonin and dopamine. A method of inhibiting both serotonergic overactivity and dopaminergic overstimulation in animals is provided by administration of a biodegradable and biocompatible microparticle composition comprising a 1,2 benzazole or a pharmaceutically acceptable acid addition salt thereof. A method of treating warm blooded animals suffering from psychotic disorders, and a method of preparing the biodegradable and biocompatible composition are also described.
Inventor(s): Mesens; Jean (Wechelderzande, BE), Rickey; Michael E. (Loveland, OH), Atkins; Thomas J. (Cincinnati, OH)
Assignee: Janssen Pharmaceutica (BE) Alkermes Controlled Therapeutics Inc. II (MA)
Application Number:08/403,432
Patent Claim Types:
see list of patent claims
Use; Composition; Compound;
Patent landscape, scope, and claims:

Analyzing the Scope and Claims of United States Patent 5,688,801

Introduction

United States Patent 5,688,801, titled "Method of inhibiting neurotransmitter activity using biodegradable and biocompatible composition," is a patent that has significant implications in the field of neuropharmacology and psychiatric treatment. This analysis will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Patent Overview

Title and Abstract The patent, issued on November 18, 1997, describes a method for treating warm-blooded animals, particularly humans, suffering from psychotic disorders. The invention involves using a biodegradable and biocompatible composition to inhibit neurotransmitter activity, which is crucial in managing conditions such as schizophrenia and other psychotic disorders[5].

Claims Analysis

Independent Claims

The patent includes several independent claims that define the scope of the invention. These claims are critical as they outline what the patent holder can enforce as their exclusive right.

  • Claim 1: This claim typically sets the broadest scope of the invention, describing the method of treating psychotic disorders using the specified biodegradable and biocompatible composition.
  • Claim 2-5: These claims narrow down the invention by specifying particular aspects such as the composition's ingredients, the method of administration, and the dosage.

Dependent Claims

Dependent claims further refine the invention by adding additional limitations to the independent claims. For example:

  • Claim 6: This might specify a particular type of biodegradable material used in the composition.
  • Claim 7: This could detail a specific method of preparing the composition.

Scope of the Patent

The scope of the patent is determined by the language of the claims. Here are some key aspects:

Biodegradable and Biocompatible Composition

The patent emphasizes the use of a biodegradable and biocompatible composition, which is a critical innovation. This ensures that the treatment is safe and minimizes side effects, making it more acceptable for long-term use[5].

Method of Treatment

The method of inhibiting neurotransmitter activity is central to the patent. This involves administering the composition in a way that effectively reduces the symptoms of psychotic disorders.

Application to Psychotic Disorders

The patent is specifically aimed at treating psychotic disorders, which includes a range of conditions such as schizophrenia. The method described is intended to provide a more targeted and safer approach to managing these conditions.

Patent Landscape

Related Patents

To understand the broader patent landscape, it is essential to look at related patents and how they interact with US Patent 5,688,801.

  • Prior Art: Searching through databases like the USPTO's Patent Public Search or international databases such as the European Patent Office's esp@cenet can reveal prior art that may have influenced this patent or similar patents that have been granted in the same field[1].
  • Patent Family: Using tools like the Global Dossier, one can identify the patent family for this application, including related applications filed in other countries and the status of these applications[1].

Litigation and Enforcement

Patent litigation can provide insights into the validity and enforceability of the patent.

  • GAO Report: Studies by the Government Accountability Office (GAO) on patent litigation trends can offer context on how patents in the pharmaceutical and biotechnology sectors are litigated and the factors that influence these lawsuits[4].

Industry Impact

The impact of this patent on the industry can be significant, especially in the development of new treatments for psychotic disorders.

  • Innovation Incentives: The patent's scope and claims can influence innovation by either encouraging or discouraging further research in the field. Narrower claims at publication are associated with a higher probability of grant and a shorter examination process, which can foster more innovation[3].

Search and Analysis Tools

To conduct a thorough analysis of this patent, several tools and resources are available:

USPTO Resources

  • Patent Public Search: This tool provides enhanced access to prior art and allows for a comprehensive search of existing patents and published patent applications[1].
  • Global Dossier: This service offers access to the file histories of related applications from participating IP Offices, which can help in understanding the global patent landscape[1].

International Databases

  • European Patent Office (EPO): The esp@cenet network provides access to Europe's patent databases and machine translations of European patents[1].
  • World Intellectual Property Organization (WIPO): The PATENTSCOPE® Search Service allows for full-text search of published international patent applications and provides machine translations for some documents[1].

Key Takeaways

  • Biodegradable and Biocompatible Composition: The patent's focus on a biodegradable and biocompatible composition highlights the importance of safety and efficacy in psychiatric treatments.
  • Method of Treatment: The specified method of inhibiting neurotransmitter activity is a key innovation in managing psychotic disorders.
  • Patent Scope and Claims: The claims define the exclusive rights of the patent holder and influence the broader patent landscape.
  • Industry Impact: The patent can drive innovation in the field by providing a safe and effective treatment method.

FAQs

Q: What is the main innovation of US Patent 5,688,801? A: The main innovation is the use of a biodegradable and biocompatible composition to inhibit neurotransmitter activity for treating psychotic disorders.

Q: How can I search for related patents? A: You can use the USPTO's Patent Public Search tool or international databases like the EPO's esp@cenet and WIPO's PATENTSCOPE® Search Service.

Q: What is the significance of the patent's claims? A: The claims define the scope of the invention and the exclusive rights of the patent holder, influencing the broader patent landscape and potential litigation.

Q: How does this patent impact the pharmaceutical industry? A: It can drive innovation by providing a safe and effective treatment method for psychotic disorders, potentially reducing side effects and improving patient outcomes.

Q: What tools are available for analyzing patent litigation trends? A: Reports from the GAO and other studies on patent litigation trends can provide valuable insights into the factors influencing patent lawsuits and their impact on the industry.

Sources

  1. USPTO - Search for patents: https://www.uspto.gov/patents/search
  2. ACUS - U.S. Patent Small Claims Court: https://www.acus.gov/research-projects/us-patent-small-claims-court
  3. SSRN - Patent Claims and Patent Scope: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2844964
  4. GAO - Assessing Factors That Affect Patent Infringement Litigation: https://www.gao.gov/products/gao-13-465
  5. Justia - US Patent for Method of inhibiting neurotransmitter activity using biodegradable and biocompatible composition: https://patents.justia.com/patent/5688801

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Drugs Protected by US Patent 5,688,801

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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